Self-puncturing liquid drug cartridges and an associated inhaler are used to deliver one or more separate doses of an aerosolized liquid drug. A cartridge includes a needle assembly coupled to a drug container. The needle assembly includes a hollow needle and is reconfigurable from a first configuration to a second configuration upon insertion of the cartridge into the inhaler. In the first configuration, the hollow needle does not extend into the container. In the second configuration, the hollow needle extends into the container. The inhaler includes an aerosol generator that includes a vibratable membrane that aerosolizes liquid drug ejected from the cartridge for inhalation by a patient.

A reservoir for a nebulizer includes: a tank or bag containing multiple doses of a fluid to be nebulized, and an indicator device for counting or indicating a number of uses performed or still possible with the reservoir, where at least one of: the reservoir includes a connector for fluidically connecting the tank or bag with the nebulizer, the indicator device is actuated by moving the connector relative to the tank or bag, and the reservoir includes or forms an eccentrical linear guidance for a driving part for driving the indicator device.

The invention relates to a capsule for use in a vaporizer, having at least one first cavity formed at least in part by a lid, side walls and bottom of the capsule, and a vaporizable active substance accommodated in the first cavity of the capsule, wherein the side walls and/or the bottom are at least in sections double-walled with an inner wall facing the first cavity of the capsule and an outer wall facing the outside of the capsule, so that at least one second cavity is formed between the inner wall and the outer wall of the capsule, inner wall facing the first cavity of the capsule and an outer wall facing the outside of the capsule, so that at least one second cavity is formed between the inner wall and the outer wall, wherein an auxiliary substance, preferably a further active substance, a chemical reactant and/or a flavoring agent is accommodated in the second cavity. A corresponding vaporizer as well as a corresponding vaporizer system are further described.

Methods are provided for acute treatment of agitation, including agitation in patients with schizophrenia or bipolar disorder, comprising administering to a subject with agitation an effective dose of a dry pharmaceutical composition comprising olanzapine, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma olanzapine concentration (C.sub.max) of at least 30 ng/mL, with (b) a mean time to C.sub.max (T.sub.max) of olanzapine of less than 0.5 hours. Dry pharmaceutical compositions and devices suitable for intranasal delivery of olanzapine are provided.

A system and method for dermal spraying includes a portable, hand-held dermal application device with disposable formulation capsules that spray a formulation unto the skin and a data transmission unit operatively connecting the dermal spray device to a mobile device. The mobile device communicates with a remote server and transmits anonymized data about the user's skin conditions and treatment history. The anonymized data may be labelled and classified by a dermatologist, and stored on a secure cloud server. The anonymized data is used to train models for serum and treatment plan recommenders.

A device configured to deliver a pressurized fluid includes a body having an input opening for receiving the pressurized fluid and an output opening for delivering the pressurized fluid, a handle defining a lumen, wherein the lumen is configured to receive a container containing the pressurized fluid, and at least one aperture fluidly connecting the lumen to an atmosphere external of the device.

The invention relates to a device for tabletting a powdered, liquid, pasty, encapsulated or granular active ingredient composition, having a magazine which has a plurality of active ingredient containers each with an individually controllable dosing device and a nozzle for the active ingredient outlet, wherein the magazine is adjustable between a plurality of setting positions relative to at least one die chamber, wherein in each of the setting positions at least one of the nozzles faces an opening of the die chamber. A corresponding method is further described.

The present invention relates to a kit comprising: a) a bag having an outlet, the outlet being closable and openable; b) a solid and/or liquid active agent precursor; and c) means for releasing a gaseous active agent or a gaseous active agent mixture from the active agent precursor; a method for producing a gaseous active agent or a gaseous active agent mixture comprising the steps: a) providing the kit; b) providing the solid and/or liquid active ingredient precursor in the bag; and c) releasing the gaseous active ingredient or the gaseous active ingredient mixture from the solid and/or liquid active ingredient precursor with the aid of the means for releasing a gaseous active ingredient or a gaseous active ingredient mixture, and a gaseous composition obtainable by the process.

The invention relates to a vaporiser head for an inhaler, in particular for an electronic cigarette product, comprising a heating element-wick structure assembly consisting of an electrically operable heating element, which has at least one liquid-conducting through-channel and a porous and/or capillary wick structure arranged at an inlet side of the heating element, and a support plate for retaining the heating element-wick structure assembly. The vaporiser head has a liquid-conducting cannula having a preferably protruding piercing region.

Methods and devices for delivering one or more substances within at least one body cavity are provided. The device includes at least one nosepiece including at least one capsule having a volume V.sub.sub of the substances; at least one base in communication with the nosepiece, the base including at least one chamber configured to confine pressurized fluid at volume V.sub.PF and pressure P.sub.PF; and at least one hollow puncturing member. The hollow puncturing member includes at least one end in fluid communication with the nosepiece and a second end in fluid communication with the base. The first and second ends are fluidly interconnected by a hollow tube. The fluid inlet port of the capsule is configured in terms of size and shape to interface in a sealable manner with the one end of the at least one puncturing member.