A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.

In some examples, a ventilator includes a pneumatic connection configured to receive supply gas; an inspiratory path configured to deliver conditioned gas to lungs of a patient; a valve pneumatically connected to the pneumatic connection and configured to allow flow of the supply gas to the inspiratory path when the valve is open and block flow of the supply gas to the inspiratory path when the valve is closed; a pressure sensor configured to measure a pressure of the supply gas at the pneumatic connection; and electronic control circuitry configured to control an opening and closing of the valve based on the measured pressure to produce a desired volume of conditioned gas in the inspiratory path.

A humidification system has a humidification source and a main gases flow path. The main gases flow path has a low pressure region and a high pressure region. In some embodiments, each of the low pressure region and the high pressure region has an aperture. The pressure difference between the apertures promotes a gases flow between the main gases flow path and the humidification source, and results in humidifying the gases in the main gases flow path.

A ventilator includes a bidirectional breath detection airline and a flow outlet airline. The flow outlet airline includes an airline outlet. The flow outlet airline is configured to be connected to an invasive ventilator circuit or a noninvasive ventilator circuit. The breath detection airline includes airline inlet. The airline inlet is separated from the airline outlet of the flow outlet airline. The ventilator further includes a pressure sensor in direct fluid communication with the breath detection airline. The pressure sensor is configured to measure breathing pressure from the user and generate sensor data indicative of breathing by the user. The ventilator further includes a controller in electronic communication with the pressure sensor. The controller is programmed to detect the breathing by the user based on the sensor data received from the pressure sensor.

An apparatus such as a fluid mixer, suitable for use with a respirator, including a venturi nozzle for flow of a pressure-controlled fluid; an ambient fluid aperture in fluid communication with the venturi nozzle; a fluid port; a pressure force multiplier in fluid communication with the fluid port; and a valve moveable relative to the venturi nozzle between a start flow position and a stop flow position; where the pressure force multiplier is configured such that fluid forced into the fluid port actuates the valve relative to the venturi nozzle; and where the pressure force multiplier is configured such that fluid withdrawn from the fluid port actuates the valve relative to the venturi nozzle. A method of using an apparatus suitable for a ventilator is also disclosed.

A system for reducing airway obstructions of a patient may include a ventilator, a control unit, a gas delivery circuit with a proximal end in fluid communication with the ventilator and a distal end in fluid communication with a nasal interface, and a nasal interface. The nasal interface may include at least one jet nozzle, and at least one spontaneous respiration sensor in communication with the control unit for detecting a respiration effort pattern and a need for supporting airway patency. The system may be open to ambient. The control unit may determine more than one gas output velocities. The more than one gas output velocities may be synchronized with different parts of a spontaneous breath effort cycle, and a gas output velocity may be determined by a need for supporting airway patency.

There are provided herein methods, devices, kits and systems utilizing respiratory mask for delivering pressurized fluid to a subject via inhalation in an efficient manner. The fluid may include gas and/or drug and by utilizing the methods, devices, kits and systems provided, efficient drug delivery to the subject's airways is achieved. The systems, devices, kits and methods further allow inducing insufflation/exsufflation in particular in subjects having impaired suffering from low neuromotor capacity, such as spinal cord injuries (SCI) patients.

A method of making a prepackaged, combustible unit of a plant based material for use in an inhalation system, metered dose inhaler, or dry powder inhaler. The method includes creating and shaping a combustible material packaging by processing leaves or plant fibers into a fibrous sheet, steaming the fibrous sheet, and using a female mold and a corresponding male mold to shape the combustible material packaging. The method further discloses filling pockets disposed within the combustible material packaging with the combustible material and sealing the combustible material packaging around the combustible material to create a prepackaged, combustible unit. Additional embodiments include various inhalation devices, inhalation systems, kits having instruction as to using the inhalation device, and methods of making the prepackaged combustible unit, and methods for using the inhalation devices.

The present disclosure pertains to a system for delivering a humidified flow of concentrated oxygen containing gas to a subject, the system comprising: a subject interface; an oxygen concentrator operatively coupled to the subject interface, the oxygen concentrator configured to provide a flow of concentrated oxygen containing gas to the subject interface via a first conduit; and an aerosol generator operatively coupled to a water supply via a second conduit, the aerosol generator configured to provide a water vapor to the subject interface via the second conduit to humidify the flow of concentrated oxygen containing gas for delivery to the subject.

A ventilator circuit apparatus is provided for the administration of an aerosolized drug from a nebulizer through an endotracheal tube to a patient on a mechanical ventilator with humidification of the breathing gases. Means to disconnect the nebulizer without interrupting the airflow to the patient is provided, with a T-fitting and three-way valve in the ventilator circuit that permits the nebulizer to be bypassed by the airflow, allowing the nebulizer to be removed from the apparatus without interrupting the flow of breathing gases to the patient. In embodiment, the nebulizer is breath-enhanced jet nebulizer. In an embodiment, the jet nebulizer is breath-actuated, by the use of an air pressure sensor that toggles the flow of pressurized air to the nebulizer that drives the jet required for nebulization.