Systems and methods that deliver a continuous partial nerve conduction block are described. A waveform generator can configure one or more direct current (DC) waveforms to provide a continuous partial nerve conduction block. One or more electrodes can deliver the one or more DC waveforms to provide the partial block to the neural structure. Feedback can be provided to the waveform generator related to the partial block. The feedback includes monitoring a property associated with the partial block and altering a parameter associated with the one or more direct current waveforms in response to the property associated with the partial block.

Systems and methods are provided for sealing an ear canal for retaining a solution in the ear canal. Adhesive earplugs are provided through which the solution can be delivered, and which, following delivery, retain the fluid in the ear canal. The systems and methods may also be useful for delivering an anesthetizing solution to the ear canal of a human patient and for maintaining the solution therein for use with an iontophoresis system for anesthetizing the tympanic membrane.

An intra-pulposus exposed electrode surface (280) is configured to be implanted in a nucleus pulposus (42) of an intervertebral disc (30), and a plurality of extra-pulposus exposed electrode surfaces (44) is configured to be implanted outside the nucleus pulposus (42), in electrical communication with the intervertebral disc (30). Control circuitry (50) separately controls at least two of the plurality of extra-pulposus exposed electrode surfaces (44), and to repeatedly alternatively assume: (a) a pressure-increasing mode of operation, in which fluid is electroosmotically driven into the nucleus pulposus (42) to increase pressure in the intervertebral disc (30), by applying a first mean voltage of less than 1.23 V between the exposed electrode surfaces (280, 44), and (b) an oxygen-generating mode of operation, in which oxygen is generated within the nucleus pulposus (42) by electrolysis, by applying a second mean voltage of at least 1.23 V between the exposed electrode surfaces (280, 44). Other embodiments are also described.

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing electricity are provided for non-human animals. Electrodes are used to deliver an electrical current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

According to a first aspect, the invention relates to a device (10) for electrochemically releasing a composition and comprising: one working electrode (30) comprising an electroactive conjugated polymer (40) containing or doped with said composition, a counter electrode (50), and a reference electrode (60). The device (10) is characterized in that it comprises electrical means (95, 100; 320; 165, 180) connected to the working electrode (30) and to the counter electrode (50) for obtaining at said working electrode (30) at least one composition releasing sequence (65) with respect to said reference electrode (60), each composition releasing sequence (65) comprising: a first voltametric pulse (70), followed by a rest period (80) during which no current is able to flow through said working electrode (30), followed by a second voltametric pulse (90), followed by an intermediate period (160) during which no current is able to flow through said working electrode (30).

A method of anesthetizing a tympanic membrane of an ear of a patient using iontophoresis is disclosed. The method involves delivering an anesthetizing drug solution to an ear canal of the patient's ear, wherein the drug solution includes an anesthetic and a buffer, and wherein the drug solution has a pH in the range of about 6.5 to about 7.5; and applying an amount of current to the drug solution, wherein the amount of applied current is increased at a rate of less than about 0.5 milliamp per second until a maximum current is achieved.

A treatment system (1) for cleaning a component part contaminated with a biofilm, in particular for cleaning bacterially contaminated surfaces of bone implants or dental implants (20), shall enable a particularly effective, locally focused and flexible treatment. For this purpose, the treatment system (1) according to the invention has a conduction element (10), which can be put into electric contact with the component needing treatment and which can be connected to a first pole of an electric supply unit (16), and a media cannula (2) which is provided for supplying a treatment liquid and whose interior is connected in an electrically conductive manner with the second pole of the electric supply unit (16).

A localizable systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.

A device for killing blood-borne pathogens, and a method of using this device to effectively remove blood-borne pathogens from the body of a human or animal is claimed. The device comprises a wire that is inserted into the blood stream of a patient, which releases metallic ions which effectively kill the pathogens. There are several embodiments, each of which has a combination of covered and uncovered portions of the wire. The wire is electrically connected to both a source of power and a Power Supply with PCB or controller/software, which controls the intensity and during of the treatment.

A system for treating a patient comprises a delivery device and injectate. The delivery device comprises an elongate shaft with a distal portion and at least one delivery element positioned on the elongate shaft distal portion. The delivery device is constructed and arranged to deliver the injectate through the at least one delivery element and into tissue to create a therapeutic restriction in the gastrointestinal tract. Methods of creating a therapeutic restriction are also provided.