A system and method for delivering radiation therapy to a patient includes generating a radiation therapy plan and adjusting a shape of at least one of a plurality of multi-leaf collimators (MLCs) arranged in an arc about a patient bed to create a respective plurality of desired beam profiles for each of the plurality of MLCs to thereby implement the ultrafast radiation therapy plan delivery. The method further includes control a radiation therapy source to execute the radiation therapy plan by creating the respective plurality of desired beam profiles for each of the plurality of MLCs.

A radiation therapy system comprising a therapeutic radiation system (e.g., an MV X-ray source, and/or a linac) and a co-planar imaging system (e.g., a kV X-ray system) on a fast rotating ring gantry frame. The therapeutic radiation system and the imaging system are separated by a gantry angle, and the gantry frame may rotate in a direction such that the imaging system leads the MV system. The radiation sources of both the therapeutic and imaging radiation systems are each collimated by a dynamic multi-leaf collimator (DMLC) disposed in the beam path of the MV X-ray source and the kV X-ray source, respectively. In one variation, the imaging system identifies patient tumor(s) positions in real-time. The DMLC for the imaging radiation source limits the kV X-ray beam spread to the tumor(s) and/or immediate tumor regions, and helps to reduce irradiation of healthy tissue (e.g., reduce the dose-area product).

Systems, methods, and computer software are disclosed for acquiring images during delivery of a radiation beam, the images capturing at least a portion of a shape representative of a radiation field generated by a radiation delivery system that includes a radiation source configured to deliver the radiation beam.

A method may include obtaining first image data relating to a region of interest (ROI) of a first subject. The first image data corresponding to a first equivalent dose level may be acquired by a first device. The method may also include obtaining a model for denoising relating to the first image data and determining second image data corresponding to an equivalent dose level higher than the first equivalent dose level based on the first image data and the model for denoising. In some embodiments, the method may further include determining information relating to the ROI of the first subject based on the second image data and recording the information relating to the ROI of the first subject.

Techniques for closed-loop feedback beam control in particle therapy delivery system can include receiving treatment plan beam parameters, receiving a determined output beam current of a present spot, generating an adjusted source beam current set point based on the treatment plan beam parameters and the determined output beam current of the present spot, and adjusting an output beam current of the present spot based on the adjusted source beam current.

The present invention provides a radiotherapeutical or radiosurgical system comprising at least two high-intensity radiation sources configured to rotate around a common rotation axis and a ring-shaped imaging device. A three-source configuration is considered as the most cost-effective and will be used as an example for illustration. The three radiation sources are specially configured with each radiation source emits a radiation beam having an angle (α1, α2 or α3 respectively) relative to the common rotation axis and targets at a common isocenter. During a radiation treatment, the angles α1, α2 and α3 are independently of each other constant or variable with a magnitude of less than ±15°, and it always remains that α1≠α2, α1≠α3, and α2≠α3. The special configuration of these high-intensity radiation sources and use of a unique compact MLC for each of the radiation sources make it possible for the system to rapidly deliver high-conformal non-coplanar stereotactic radiation treatment in one gantry rotation without any couch rotation. Consequently, a ring-shaped imaging device, which does not allow couch rotation, can be integrated into the system to provide high-precision image guidance. Therefore, the present invention can deliver high precision and high-conformal non-coplanar stereotactic radiation treatment to any part of the body in an extremely short time (0.1-20 seconds), which may exhibit numerous advantages over the prior art, such as reduction of radiation damage to the circulating immune cells in blood and mitigation of patient motion-induced problems, among others.

Methods, devices and systems for ultra-high dose radiotherapy are disclosed. The described techniques rely in-part on active switching control of a photoconductive switch during the time the accelerator is accelerating charged particles to produce the output radiation at the desired dose rates. One flash radiotherapy system includes an induction accelerator, and a controllable switch coupled to the induction accelerator. The switch is operable to produce a plurality of voltage pulses to drive the induction accelerator. The radiotherapy system also includes a radiation measurement device to measure output radiation produced by the radiotherapy system and provide feedback to the controllable switch. The controllable switch is operable to, based on the received feedback, modify an amplitude, shape, spacing, number or width of the voltage pulses that are supplied to the particle accelerator to deliver the desired output radiation.

Disclosed herein is a method of positioning a patient for radiotherapy treatment using a radiotherapy system. The method comprises determining a first target position for the patient for radiotherapy treatment; implementing a spatial relationship between the patient and at least a part of the radiotherapy device, at a first time (t.sub.1), according to the first target position; providing radiotherapy treatment to the patient; determining a current position of the patient, at a second, subsequent time (t.sub.2); and determining whether a change of a spatial relationship between the patient and at least a part of the radiotherapy device should be made, according to the first target position.

An interventional therapy system may include at least one catheter configured for insertion within an object of interest (OOI); and at least one controller which configured to: obtain a reference image dataset including a plurality of image slices which form a three-dimensional image of the OOI; define restricted areas (RAs) within the reference image dataset; determine location constraints for the at least one catheter in accordance with at least one of planned catheter intersection points, a peripheral boundary of the OOI and the RAs defined in the reference dataset; determine at least one of a position and an orientation of the distal end of the at least one catheter; and/or determine a planned trajectory for the at least one catheter in accordance with the determined at least one position and orientation for the at least one catheter and the location constraints.

A high-energy radiation treatment system can comprise a laser-driven accelerator system, a patient monitoring system, and a control system. The laser-driven accelerator system, such as a laser-driven plasma accelerator or a laser-driven dielectric microstructure accelerator, can be constructed to irradiate a patient disposed on a patient support. The patient monitoring system can be configured to detect and track a location or movement of a treatment volume within the patient. The control system can be configured to control the laser-driven accelerator system responsively to the location or movement of the treatment volume. The system can also include a beam control system, which generates a magnetic field that can affect the radiation beam and/or secondary electrons produced by the irradiation beam. In some embodiments, the beam control system and the patient monitoring system can comprise a magnetic resonance imaging system.