A radiation system is provided. The radiation system may include a bore accommodating an object, a rotary ring, a first radiation source and a second radiation source mounted on the rotary ring and a processor. The first radiation source may be configured to emit a first cone beam toward a first region of the object. The second radiation source may be configured to emit a second beam toward a second region of the object, the second region including at least a part of the first region. The processor may be configured to obtain a treatment plan of the object, the treatment plan including parameters associated with radiation segments. The processor may be further configured to control an emission of the first cone beam and/or the second beam based on the parameters associated with the radiation segments to perform a treatment and a 3-D imaging simultaneously.

Systems and methods for managing motions of an anatomical region of interest of a patient during image-guided radiotherapy are disclosed. An exemplary system may include an image acquisition device, a radiotherapy device, and a processor device. The processor device may be configured to control the image acquisition device to acquire at least one 2D image. Each 2D image may include a cross-sectional image of the anatomical region of interest. The processor device may also be configured to perform automatic contouring in each 2D image to extract a set of contour elements segmenting the cross-sectional image of the anatomical region of interest in that 2D image. The processor device may be further configured to match the set of contour elements to a 3D surface image of the anatomical region of interest to determine a motion of the anatomical region of interest and to control radiation delivery based on the determined motion.

A method provides real-time correction of the spatial position of the central beam of radiation therapy devices and therapy simulators, along with the patient position. In particular, the method relates to the real-time correction of irradiation positions of the collimator and/or the position of the patient positioning table during the performance of radiation therapy or therapy simulation. Positional deviations of the central beam of existing radiation therapy devices are reduced. Position adjustments of the collimator elements and/or of the patient support table are carried out through functional connections of separate control modules via separate adjustment devices. Those are added to the collimator and/or patient support table. Calculation of the correction movements takes place outside the radiation therapy device in the irradiation planning system and/or in at least one microcontroller of the control system of the radiation therapy device.

The invention comprises a method and apparatus for tuning a charged particle beam path of a charged particle beam system used to treat a tumor of a patient, comprising the steps of: positioning a two-dimensional charged particle detector in a beam line downstream from a magnet pair; operating windings of the magnet pair at a first power level to generate a first magnetic field; measuring a beam position with the first two-dimensional charged particle detector; adjusting a correction magnetic field by driving voltage of a correction coil at a second power level, the second power level less than five percent of the first power level, where the first magnetic field and the correction magnetic field combine to yield an operational magnetic field; and the steps of measuring and adjusting the correction magnetic field changing the operational magnetic field to adjust a measured beam position toward a target beam position.

In a radiation therapy system, treatment X-rays are delivered to a target volume at the same time that imaging X-rays are also delivered to the target volume for generating image data of the target volume. That is, during an imaging interval in which imaging X-rays are delivered to the target volume, one or more pulses of treatment X-rays are also delivered to the target volume. In each pixel of an X-ray imaging device of the radiation therapy system, image signal is accumulated during portions of the imaging interval in which only imaging X-rays are delivered to the target volume and is prevented from accumulating in each pixel during the pulses of treatment X-rays.

A multimodal imaging apparatus, comprising a rotatable gantry system positioned at least partially around a patient support, a first source of radiation coupled to the rotatable gantry system, the first source of radiation configured for imaging radiation, a second source of radiation coupled to the rotatable gantry system, the second source of radiation configured for at least one of imaging radiation or therapeutic radiation, wherein the second source of radiation has an energy level more than the first source of radiation, and a second radiation detector coupled to the rotatable gantry system and positioned to receive radiation from the second source of radiation, and a processor configured to combine first measured projection data based on the radiation detected by the first detector with second measured projection data based on the radiation detected by the second detector, and reconstruct an image based on the combined data, wherein the reconstructing comprises at least one of correcting the second measured projection data using the first measured projection data, correcting the first measured projection data using the second projection data, and distinguishing different materials imaged in the combined data using the first measured projection data and the second measured projection.

The invention comprises a method and apparatus for imaging a tumor with X-rays while, simultaneously or alternatingly, treating or imaging the tumor with positively charged particles. An X-ray imaging system, such as one or two sets of a cone beam X-ray source coupled to an X-ray detector, is rotatable about a first axis and a patient. The X-ray imaging system is positioned off axis a path of charged particles delivered through an exit port of a nozzle system from a synchrotron and does not block a path of the positively charged particles from the exit nozzle to the patient or an imaging path from the patient to a scintillation detector. Fiducial indicators are used to confirm an unobstructed path of the positively charged particles in a treatment room comprising many movable elements, such as the X-ray imaging system and a patient positioning system/couch.

A method of positioning a patient for a radiation treatment and/or of monitoring a position of a patient during a radiation treatment is provided. The method includes providing surface data acquired using a 3D surface scanner of a surface of at least a body part of the patient that is to be irradiated in a radiation treatment. The surface data are calibrated with respect to a relative position of the 3D surface scanner and an isocenter position of a radiation treatment apparatus. A beam path and/or frustum of a radiation beam is determined based on planning data for the radiation treatment and intersected with at least a part of the surface of the patient represented by the surface data. Further, at least a first portion of the patient's surface located inside the beam path and/or a second portion of the patient's surface located outside the beam path is calculated.

Systems and techniques may be used to estimate a patient state during a radiotherapy treatment. For example, a method may include generating a dictionary of expanded potential patient measurements and corresponding potential patient states using a preliminary motion model. The method may include training, using a machine learning technique, a correspondence motion model relating an input patient measurement to an output patient state using the dictionary. The method may include estimating, using a processor, the patient state corresponding to an input image using the correspondence motion model.

Disclosed herein are methods for patient setup and registration for the irradiation of target tissue regions. A method for positioning a patient for radiation therapy may include acquiring an image of a first patient target region and a second patient target region. A first set of patient position-shift vectors may be calculated based on the acquired image and a treatment planning image of the first patient target region. A second set of patient position-shift vectors may be calculated based on the acquired image, a treatment planning image of the second patient target region, and the first set of patient position-shift vectors. The patient may be positioned according to the first set of patient position-shift vectors in a first location. The patient may be moved to a second location and positioned according to the second set of patient position-shift vectors.