An image-guided therapy delivery system includes a therapy generator configured to generate a therapy beam directed to a time-varying therapy locus within a therapy recipient, an imaging input configured to receive imaging information about a time-varying target locus within the therapy recipient, and a therapy controller. The therapy generator includes a therapy output configured to direct the therapy beam according to a therapy protocol. The therapy controller is configured to automatically generate a predicted target locus using information indicative of an earlier target locus extracted from the imaging information, a cyclic motion model, and a specified latency, and automatically generate an updated therapy protocol to align the time-varying therapy locus with the predicted target locus.

Provided is an operation procedure of a positioning device of a radiation therapy system. The radiation therapy system includes a radiation generation device used to generate therapeutic radiation, an irradiation chamber used to accommodate an irradiation subject receiving the radiation, a management chamber used to achieve irradiation control, and a support device used to transport and support the irradiation subject. The support device includes a support member supporting the irradiation subject, an adjustment assembly for adjusting a spatial position of the support member, and a joining assembly fixedly connecting the support member and the adjustment assembly together in a detachable manner. The support member at least includes a first support member and a second support member having a different size and/or shape from the first support member. The invention allows switching between support members having different sizes and/or shapes according to an actual use requirement.

Subject positioning systems and methods are provided. A method may include obtaining first information of at least part of a subject when the subject is located at a preset position, and determining, based on the first information, a first position of each of one or more feature points located on the at least part of the subject. The method may include obtaining, using an imaging device, second information of the at least part of the subject when the subject is located at a candidate position. The method may further include determining, based on the second information, a second position of each of the one or more feature points, a first distance between the first position and the second position for each feature point of the one or more feature points, and a target position of the subject based at least in part on the one or more first distances.

A control circuit controls real-time administration of a radiation-treatment plan that administers a therapeutic radiation dose to a patient. This includes compensating for a first movement as regards the application setting using a first treatment-administration modality and responding to detection of a second movement by using a second treatment-administration modality that is different from the first treatment-administration modality.

Disclosed herein are system, method, and computer program product embodiments a 6 degree-of-freedom (6DoF) correction trajectory in order to compensate movement of a treatment target in a patient supported by a patient support end-effector. An embodiment operates by receiving a starting end-effector position, a starting clinical target position, and a target destination position. The target destination position corresponds to a position in space receiving targeted treatment from a treatment delivery device. The embodiment determines a destination end-effector position in 6DoF associated with the end-effector that would cause the target to be positioned on the target destination position. A trajectory is calculated between the starting end-effector position and the destination end-effector position. The embodiment transmits, to a mechanical device controlling movement of the end-effector, one or more signals causing the end-effector to move from the starting end-effector position to the destination end-effector position along the determined trajectory.

The invention comprises a method and apparatus for directing protons to a tumor, comprising the steps of: (1) holding a patient with a patient support; (2) providing an imaging system comprising: a rotatable unit at least partially surrounding an axial perimeter of the patient support, a translation guide rail, an imaging source attached to the rotatable unit, and an imaging detector attached to the rotatable unit; (3) translating and rotating the imaging source and the imaging detector relative to the patient support using the translation guide rail and the rotatable unit; and (4) providing an attachment section connected: on a first end to a robotic arm positioning system and on a second end to the patient support and the imaging system, the robotic arm positioning system repositioning, relative to a nozzle system linked to the synchrotron, the attachment system supporting the patient support system and the imaging system.

The invention comprises a method and apparatus for using a single robotic positioning arm to simultaneously move, relative to a proton beam path entering a treatment room containing the patient, both: (1) a patient support and (2) an imaging system. The robotic arm moving the imaging system and patient independently from movement of a nozzle system directing protons into the treatment rooms allows: simultaneously translating past the patient and rotating around the patient an X-ray source of the imaging system; translating a rotatable unit, of the imaging system, longitudinally past the patient on a translation guide rail; moving the patient support and the imaging system through at least four degrees of freedom relative to a movable proton beam; and/or simultaneous or alternating movement of the proton treatment beam and the imaging system relative to the patient.

A rotatable targeting magnet apparatus and method of use thereof is described where the rotatable targeting magnet rotates independently of a beamline arc at the end of the beamline arc, where the arc is after an accelerator and before the patient in a cancer therapy system. The rotatable targeting magnet directs the charged particle beam, such as vertically, using applied current to the targeting magnet while rotation of the magnet allows scanning across the tumor. Rotation of the patient relative to the charged particle allows distribution of trailing Bragg peak energy within and/or circumferentially about the tumor.

Visualizing a deformation amount or displacement amount of a region of interest in therapy rendered in an image upon aligning images used in radiation therapy allows for enhancing an accuracy of alignment. In a positioning system 104, an image processing unit 201 calculates a deformation parameter using a non-rigid registration method for a region of interest having been set by a treatment planning device 101 based on a treatment plan CT image and three-dimensional tomographic image imaged for bed positioning and calculates a displacement amount parameter for a region extracted using a region extraction method. The image processing unit 201 calculates a positioning parameter representing a displacement amount of a bed based on the calculated deformation parameter and displacement amount parameter and displays the respective parameters together with an alignment image, thereby allowing for confirmation of the deformation amount and displacement amount.

The present relates to a positioning and shaping shell manufacturing method for manufacturing a positioning and shaping shell comprising a positioning step consisting in positioning and supporting a target body portion with a transparent body shaper in a predetermined position on a positioning board presenting at least one transparent portion permitting scanning through it, an image acquisition step consisting in a target body portion surface scan imaging also via the transparent portion of the board and said transparent body support, a software computing step where the acquired image data are sent and processed in a processing unit, and a producing step consisting in producing a 3D positioning and shaping shell model via additive or subtractive manufacturing method based in the processed image data.