The method of delivering an implant in an intracranial vessel includes deploying an anchor of a tethering device in an anchoring vessel forming a first fixation point and advancing a guide-sheath to a location near the anchoring vessel. The tethering device has a tether extending proximally from the anchor and the guide-sheath has at least one lumen. The method includes attaching the guide-sheath to the tether of the tethering device forming a second fixation point proximal to the first fixation point, delivering an implant through the lumen of the guide-sheath towards a treatment site distal to the first fixation point and located within an intracranial vessel, and deploying the implant at the treatment site. Related devices, systems, and methods are also provided.

The present technology relates to aneurysm devices with additional anchoring mechanisms, and associated systems and methods. The aneurysm device is endovascularly deliverable to a site proximate an aneurysm near a parent artery with bifurcating branches. The device can include a closure structure comprising a distal-facing aspect configured to at least partially occlude the aneurysm. The closure structure can be formed from a generally flat pattern and is transformable between a compressed configuration and a deployed configuration. The device can also have one or more lodging elements which fold to form loop elements configured for anchoring within at least one of the bifurcating branches. The struts of the lodging elements can include hinge points which bias the folding of the lodging elements. The devices further include a supplemental stabilizer connected to the closure structure and configured to reside in the parent artery.

A method of treatment including: selecting tissue to be exposed to radiation for gradual closure of one or more blood vessel within the tissue to be exposed radiation; selecting radiation levels to promote gradual constriction of the one or more vessel; exposing the tissue to be exposed radiation to selected radiation levels.

Heart valve replacement often involves complications associated with paravalvular leaks. Vascular plug and occlusive devices, as well as heart valves particularly beneficial in treating the phenomenon of paravalvular leaks are described to address this issue.

An embodiment includes a process for treating an abdominal aortic aneurysm (AAA) endoleak with a shape memory polymer (SMP) foam device. First, a bifurcated stent graft is placed within the aneurysm while a micro guidewire is positioned within the aneurysm for future catheter access. Second, after placing the iliac graft extension, a catheter is introduced over wire to deliver embolic foams. Third, embolic foams expand and conform to the aneurysm wall. Fourth, embolic foams create a stable thrombus to prevent endoleak formation by isolating peripheral vessels from the aneurysm volume.

An implant having an elongated portion and an expandable braided sack portion can be delivered through a catheter and implanted in an aneurysm such that elongated portion loops within the braided sack, the braided sack contacts a majority or all of the aneurysm wall, and the braided sack at least partially occludes the aneurysm neck.

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include an implantable medical device and a constraining line conduit arranged around a circumference of the implantable medical device. The apparatuses, systems, and methods may also include a constraining line arranged through the constraining line conduit.

An intravascular flow diverter for treating an aneurysm of a blood vessel is provided. The intravascular flow diverter includes a stent including a plurality of wires coiled to form an expandable structure. The intravascular flow diverter includes a cover disposed on at least a portion of the outer surface of the device. The cover includes a first portion configured to be disposed directly against a neck of the aneurysm. The membrane includes at least one second portion configured to be disposed adjacent to and not directly over the aneurysm. The first portion has a first porosity to blood flow, and the second portion has a second porosity to blood flow greater than the first porosity. Related methods of use and manufacturing are also provided.

Neurovascular flow diverter and delivery systems, and methods of using the same are disclosed herein. The systems can include an introducer sheath, a catheter, a deployable flow diverter that can be contained in the introducer sheath or in the catheter, a core wire, and one or several deployment features coupled to the core wire and engaging the flow diverter. The deployment features can include one or more of a pusher, one or several friction bumps, one or several deployment coils, a claw mechanism, a self-expanding element, a supporting coil, a tip coil, and/or an atraumatic tip. One or more of the deployment features can be radiopaque.

An intrasacular flow diverter is provided. The intrasacular flow diverter includes a plurality of wires coiled to form a collapsible, substantially spherical frame configured to expand within, and substantially conform to a shape of an inside surface of, the aneurysm. The intrasacular flow diverter includes a membrane disposed on at least a portion of the outer surface of the substantially spherical frame. The membrane includes a first portion configured to be disposed directly against a neck of the aneurysm. The membrane includes a second portion configured to be disposed within the aneurysm and distal to the neck of the aneurysm. The first portion has a first porosity to blood flow and the second portion has a second porosity to blood flow greater than the first porosity. Related methods of use and manufacturing are also provided.