The present disclosure is related to an occlusion device having a mesh structure. The occlusion device configured to transition between a two-dimensional configuration and a three-dimensional configuration. In the two-dimensional configuration and at rest, the occlusion device is flat or planar. In the three-dimensional configuration, the occlusion device defines an internal volume.

An endovascular self-expanding stent system that can include a braid with a proximal end, a distal end, and a lumen formed therebetween. The braid can be formed from one or more wires woven to comprise interstices. A first expansion ring can be connected to the proximal end of the braid. A second expansion ring can be connected to the distal end of the braid. Each expansion ring can include a frame that imparts an outwardly expanding radial force to the braid. The frame can include a plurality of elongate members interconnected by one or more intersections.

A system for treating an aneurysm comprises an elongate flexible shaft and an expandable member. An expandable scaffold is disposed over the expandable member and may be expanded from a collapsed configuration to an expanded configuration. A double-walled filling structure is disposed over the scaffold and has an outer wall and an inner wall. The filling structure is adapted to be filled with a hardenable fluid filing medium so that the outer wall conforms to an inside surface of the aneurysm and the inner wall forms a substantially tubular lumen to provide a path for blood flow. In the expanded configuration the scaffold engages the inner wall of the filling structure. A tether is releasably coupled with the filling structure and the flexible shaft thereby constraining axial movement of the structures relative to each other.

An occlusion device that includes an inner embolic element with a proximal section and a distal section, wherein the distal section has a first stiffness and the proximal section has a second stiffness. An expandable mesh is included that is capable of being transformed between a collapsed position and an expanded position, wherein the expandable mesh is disposed over a portion of the proximal section of the inner embolic device and the first stiffness is greater than the second stiffness.

A non-occlusive device is provided that includes a coilable section and a docking section. The coilable section is configured to become coiled into a coil when deployed from a microcatheter within a vascular malformation. The coil is shaped so as to define a sequence of concentric loops. The coil is configured to bridge a neck of the vascular malformation so as to at least partially cover an orifice of the vascular malformation, when in use. The docking section is configured to be deployed from the microcatheter within the vascular malformation. The docking section is configured to, when in use, perform one or more functions selected from the group consisting of: anchoring the device within the vascular malformation, stabilizing the device within the vascular malformation, assisting with positioning of the device within the vascular malformation, and intertwining detachable coils delivered to the vascular malformation. Other embodiments are also described.

A device for occluding a vasculature of a patient including a micrograft having an absorbent polymeric structure with a lumen of transporting blood. The micrograft has a series of peaks and valleys formed by crimping. The occluding device is sufficiently small and flexible to be tracked on a guidewire and/or pushed through a microcatheter to a site within the vasculature of the patient. Delivery systems for delivering the micrografts are also disclosed.

A system includes an inner filling structure around a stent-structure and an outer filling structure around the inner filling structure. The inner filling structure can be configured to produce a proximal seal with a first portion of an artery at a proximal end and a distal seal with a second portion of an artery at a distal end when the inner filling structure is in an inflacted state. The outer filling structure can have an inner surface surrounding at least a portion of the inner filling structure. The outer filling structure can be configured to be inflatable to occupy a space within an aneurysm at a lower pressure than a pressure in the inner filling structure.

A packaging for an implant to hold the implant in a first condition. The packaging including a first packaging tube and a container, wherein the implant is movable from the container into the first tube and maintained within the first tube in a second condition, the implant having a first transverse dimension in the first condition and a second transverse dimension in the second condition, the second transverse dimension being less than the first transverse dimension.

A medical instrument is disclosed having a structure capable of preventing liquid circulation between an inner layer side and an outer layer side of a peripheral wall portion. The medical instrument includes a main body portion in which a center hole and a radially outward space are partitioned by a tubular peripheral wall portion. The peripheral wall portion includes at least a first layer on which a hydrophilic member, in which a hydrophilic coating is formed on a first base portion, is disposed and a second layer on which a hydrophobic member, in which a hydrophobic coating is formed on a second base portion, is disposed. The peripheral wall portion is configured by the first layer and the second layer being stacked along a radial direction. As a result of swelling of the hydrophilic coating, the adjacent hydrophilic members come into contact with each other.

Disclosed herein is a method for providing localized treatment at a target site in a blood vessel of a subject. The method includes (i) delivering to a vicinity of a target site in a blood vessel a water-immiscible fluid such as to displace blood from the vicinity of the target site, and (ii) administering an active agent to the target site, wherein the water-immiscible fluid and the active agent are mutually immiscible, or substantially mutually immiscible, so that the active agent is trapped by the water-immiscible fluid.