The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

Disclosed is a laser apparatus including a laser generator comprising a laser medium, a pumping light source providing light to the laser medium, a first mirror and a second mirror arranged with the laser medium therebetween, and configured to generate a laser beam of a first wavelength, a secondary harmonic wave generator configured to generate a laser beam of a second wavelength from the laser beam of a first wavelength, a light modulator arranged between the laser medium and the secondary harmonic wave generator and configured to adjust a pulse width of the laser beam of a first wavelength, and an output adjustor configured to adjust an output of the laser beam of a second wavelength generated in the secondary harmonic wave generator.

An apparatus for the treatment of a soft tissue injury (eg a soft tissue injury that may be the cause, or contributes to, acute or chronic pain such. as sciatica) comprising; a thermal imaging arrangement to scan, a least a portion of a patient to provide a thermal image; a processing arrangement to review the thermal image to determine a point or region of thermal anomaly on the patient; a laser treatment device to provide a laser beam (eg for low-level laser treatment); and a guidance arrangement for the laser treatment device to guide the laser beam to the point or region of thermal anomaly on the patient as determined by the processing arrangement; to thereby treat the patient.

The device comprises: a laser source (7); a treatment hand-piece (13); a light guide (11) configured to convey a laser beam from the laser source to the hand-piece. The hand-piece (13) is configured to vary the inclination of the laser beam (F2) exiting from the hand-piece with respect to a longitudinal axis (A-A) of the hand-piece.

The invention provides systems and method for the removal of diseased cells during surgery

The invention provides systems and method for the removal of diseased cells during surgery.

The present invention relates to an endoscope (2) having first conduction means configured to transmit electromagnetic waves between an illumination device (40) for illuminating an observation area (41) and a distal end (5) of the endoscope (2), and second conduction means configured to transmit electromagnetic waves between a therapy device (42) for treating a therapy area (43) within the observation area (41) and the distal end (5) of the endoscope (82). The endoscope is characterized by a third conduction means configured to transmit electromagnetic waves between an optical coherence tomography device (37) by means of which depth information about said area can be obtained during treatment of the therapy area (43) and the distal end (5) of the endoscope (2).

The present disclosure is directed to systems and methods that facilitate delivery of a therapeutic agent into the skin of a subject. A first mechanism can create a first angled channel through a first location on a surface of a subject's skin at a first angle relative to the surface of the subject's skin. A second mechanism, associated with the first mechanism, can create a second angled channel through a second location on the surface of the subject's skin at a second angle relative to the surface of the subject's skin. The first angled channel and the second angled channel intersect to form a connected channel under the surface of the subject's skin.

A surgical probe is configured to be inserted into a body cavity and to emit beams of light to ablate tissue within the body cavity. The probe further includes sensors to detect properties of tissue in the body cavity and a source of suction to remove material produced by ablation of tissue within the body cavity. The sensors could be configured to operate in combination with beams of light emitted by the surgical probe to detect the location, geometry, fluorophore content, or other information about tissue in the body cavity. The surgical probe can additionally include suction port(s) to secure portions of tissue relative to the surgical probe to allow ablation of portions of the secured tissue and to allow detection of properties of portions of the secured tissue that are maintained in contact with the surgical probe by the suction port(s).