A spinal cage with a wall extending in a longitudinal direction defining an interior space is disclosed. There is also provided a deployable element in movable relation to the spinal cage.

A meniscus prosthesis includes a core made of a first biocompatible, non-resorbable material having a first tensile modulus. The core includes an arc-shaped body having: a first end having a first through-hole; a second end having a second through-hole; a curved intermediate section connecting the first end and the second end; a first surface configured to face a first interior surface of the joint during use and a second surface configured to face a second interior surface of the joint during use, an inner edge and an outer edge. The core comprises a transverse cross-section in which the width is greater than the height along the length of the core. A cushioning material surrounds the intermediate section of the core, the cushioning material being made of a second biocompatible, non-resorbable material having a second tensile modulus, which is lower than a tensile modulus of the first material.

A mould adapted to be introduced into a joint of a human patient for resurfacing at least one carrying contacting surface of said joint is provided. The mould is adapted to receive material for resurfacing at least one carrying contacting surface of said joint. The mould is further adapted to be resorbed by the human body or melt after having served its purpose.

Provided is an implantable composite which includes a plurality of resorbable ceramic particles with or without a biodegradable polymer. The resorbable ceramic particles can be granules including carbonated hydroxyapatite and tricalcium phosphate in a ratio of 5:95 to 70:30. Some resorbable ceramic particles are granules, which include carbonated hydroxyapatite and tricalcium phosphate in a ratio of 5:95 to 70:30. The resorbable ceramic particles have a particle size from about 0.4 to about 3.5 mm. The implantable composite is configured to fit at or near a bone defect as an autograft extender to promote bone growth. Methods of using the implantable composite are also provided.

The present disclosure provides a system of gender specific pharmaceuticals. The system includes a first package of a pharmaceutical for use by a male and a second package of a pharmaceutical for use by a female. The first package includes a pharmaceutical for use by a male and a first label coupled to the first package, wherein at least one of the first package and first label includes a male specifier and a recommended male dosage. The second package includes a pharmaceutical for use by a female and a second label coupled to the second package, wherein at least one of the second package and second label includes a female specifier and a recommended female dosage.

A spinal cage with a wall extending in a longitudinal direction defining an interior space is disclosed. There is also provided a deployable element in movable relation to the spinal cage.

An inserter instrument for inserting an intervertebral fusion cage having curved sidewalls, comprising: a) a threaded securement rod that mates with the cage via screw threads; b) a cannulated cage holder to receive the rod and hold the cage in position as the sheath is retracted; and c) a bulleted cannulated sheath,
wherein the sheath is curved and comprises a superelastic shape memory material having a curved configuration and a straight configuration.

Scaffolds for use in bone tissue engineering include a skeleton and a host component. Methods of preparation of scaffolds include identification of biodegradation properties for the skeleton and the host component. The skeleton is constructed to form a three-dimensional shape. The skeleton is constructed of a first material and has a first rate of biodegradation. The host component fills the three-dimensional shape formed by the skeleton. The host component is constructed of a second material and has a second rate of biodegradation. The first rate of biodegradation is slower than the second rate of biodegradation.

Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.

Various embodiments disclosed relate to an implant. The implant includes a substrate. The implant further includes a monolithic layer comprising a biocompatible metallic material, having at least one of an amorphous and a crystalline microstructure contacting the substrate.