A surgical kit including a hydrogel implant suitable for use in a carpometacarpal joint includes an upper surface, a lower surface, and sidewalls extending between the upper surface and the lower surface, a plunger, and an introducer for depoloying the implant is provided.

According to some embodiments, a tool for creating a wedge opening within a bone tissue is disclosed. The tool includes an outer member, a cutting member, and an inner member. The inner member moves within the inner passage of the cutting member where when the inner member is moved within the inner passage of the cutting member, the at least one cutter radially expands at an angle relative to a longitudinal axis of the tool.

An improved new method of making a multi-component implant comprising a solid hydrogel, a porous hydrogel, and a porous rigid base suitable for implantation into a mammal, to treat, repair or replace defects and/or injury biological tissue as well as the implant made from the improved method. The invention also includes an improved method for making devices, constructs, and materials comprising a hydrogel and a porous rigid material. The invention also includes a mold and kits for performing the methods.

According to some embodiments, a method of creating for creating a reverse tapered opening within tissue comprises creating a cylindrical opening within a targeted anatomical site of a subject using a first device and removing additional tissue from the sidewalls of the cylindrical opening using a cutting member to create a reverse tapered opening within the targeted anatomical site using a second device, wherein, once the reverse tapered opening is created, a diameter or other cross-sectional dimension of a bottom surface of the opening is larger than a diameter or other cross-sectional dimension of a top surface of the opening.

Scaffolds for use in bone tissue engineering include a skeleton and a host component. Methods of preparation of scaffolds include identification of biodegradation properties for the skeleton and the host component. The skeleton is constructed to form a three-dimensional shape. The skeleton is constructed of a first material and has a first rate of biodegradation. The host component fills the three-dimensional shape formed by the skeleton. The host component is constructed of a second material and has a second rate of biodegradation. The first rate of biodegradation is slower than the second rate of biodegradation.

An injury or defect in articular cartilage is treated with a matrix implant that is applied above a barrier composition. The polymer-containing barrier composition is applied to the bottom of a cartilage lesion. The barrier composition can block migration of cells, blood, or other material from subchondral bone into the cartilage lesion.

An implant system includes a first portion, a second portion, and a third portion. The first portion includes a hydrogel. The second portion includes a porous material and the hydrogel in pores of the porous material. The third portion includes the porous material. The first portion is free of the porous material. The third portion is free of the hydrogel. Methods of making and using the implant system.

A method for use of a double-structured tissue implant or a secondary scaffold stand-alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand-alone secondary scaffold implant or unit for treatment of tissue defects.

An implant device used to replace and restore the function of the knee meniscus in a human. The compliant, yet resilient device is comprised of a biocompatible, non-degradable three-dimensional body comprised of at least a central body, a second structure, a third structure, and a coating. The device is concentrically aligned wherein the second structure is adjoined to the central body wherein the third structure is adjoined on the central body opposite of the second structure. The third structure further features a first and a second pulling element which is coupled to the central body and forms the outer periphery and major circumference of the device. The device is comprised of multiple components which provide tensile strength, compressive resilience, and attachment mechanisms for replacing the meniscus. Each structure is comprised of multiple surfaces which are further reinforced, separated, and connected by an individual plurality of vertical elements. The implantable device further features a surface coating on the surface of the central body.

Disclosed is an implant for implantation in a joint that includes a first portion, a second portion, and a third portion. The first portion includes a hydrogel. The second portion includes a porous material and the hydrogel in pores of the porous material. The third portion includes the porous material. The first portion is free of the porous material, the third portion is free of the hydrogel, and the pores of the porous material in the second portion are different than the pores of the porous material in the third portion.