Shoulder arthroplasty systems and configurations for components thereof are described. For example, implant systems for a total should arthroplasty (TSA), hemi shoulder arthroplasty, and reverse should arthroplasty (RSA) are described. In addition, exemplary configurations for baseplates, glenoid components, glenosphere components, humeral components, humeral head components, humerosocket components, connectors, and adaptors, are described.

A hip/shoulder prosthesis includes: a head component; a metaphyseal component; a diaphyseal nail, and a locking device. The head component includes: a front face and rear face; with a bore, and first and second shaped recesses in the rear face. The metaphyseal component includes: a central transverse aperture at an angle to the metaphyseal component's axis; a first end configured for threaded engagement within the bore of the head component; and a longitudinal hole that begins at the second end, transects the transverse aperture and reaches the first end, to receive the locking device. The diaphyseal nail is inserted in the femoral or humeral canal, and includes: fastening apertures that receive corresponding screws for fastening the diaphyseal nail to the femur or humerus; a portion configured to he received within, and engage, the transverse aperture of the metaphyseal component, and a transverse hole configured to receive the locking device.

Devices and methods of correcting vertebral misalignment, including, e.g., spondylolisthesis, are disclosed. In one embodiment, a vertebral implant may include an assembly configured to be secured to a first vertebral body, wherein the assembly includes a frame made of a first material and at least one end plate made of a second material different than the first material; a reducing plate configured to be slidably received over the central portion, wherein the reducing plate is configured to be secured to a second vertebral body; and an actuator configured to move the reducing plate relative to the frame.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

The present invention provides a prosthetic wrist implant comprising: a radial implant component having an elongated radial stem extending proximally adapted for attachment to radius, a carpal implant component having a distal surface adapted for attachment to one or more carpal bones, and a interposed component between the radial implant component and the carpal implant component that is flexible and allows for changes in orientation between the radial component and the carpal components relative to each other component.

A method for treating a spine includes the steps of: creating a surgical pathway in a body along a first surgical approach to a surgical site including vertebral tissue; creating a surgical pathway in the body along a second surgical approach to the surgical site including the vertebral tissue; disposing a fulcrum with an intervertebral disc space of the vertebral tissue via the first surgical approach; and manipulating the vertebral tissue via the second surgical approach. Spinal implants, surgical instruments and systems are disclosed.

An electronically assisted artificial vertebral disc having an upper disc plate and a lower disc plate is disclosed. An actuator imparts movement to at least one of the upper and lower disc plates. A control device controls the actuator and the amount of movement between the disc plates. The actuator includes a plurality of either linear actuators or rotary actuators that are driven by electric motors in response to the control device. The control device includes at least a first sensor for detecting the position of the actuator and at least a second sensor for detecting the spatial orientation of at least one of the upper and lower disc plates. The control device also preferably includes a microprocessor that calculates the desired positions of the upper and lower disc plates and provides a control signal to the actuator to drive the upper and lower disc plates to their desired positions.

The artificial joint of the present invention is provided with a cup having a first housing part that opens on one first-direction side, an insert that is housed in the first housing part and has a second housing part that opens on one first-direction side, a movable member having a spherical head part rotatably housed in the second housing part and a neck part extending from the head part, and a connecting part that connects the insert to the cup pivotably around a pivotal axis extending in a second direction; the neck part contacting an edge part of the insert by pivoting around the pivotal axis; the insert pivoting around the pivotal axis; and part of the opposite side of the side pushed in by the neck part across the pivotal axis protruding from the cup to one first-direction side.

An intervertebral implant includes a body with a first face, a second face connected to the first face, and an axis of rotation. The body defines a hollow space for connecting to an insertion device, the hollow space being accessible through an opening formed between the first and second faces. The opening is elongate and extends around the axis of rotation to facilitate pivoting of the implant relative to the insertion device about the axis of rotation to a first angular position and a second angular position. The implant further includes a first abutment surface that engages the insertion device in a form-fit manner at the first angular position, and a second abutment surface that engages the insertion device in a form-fit manner at the second angular position. The opening can also engage the insertion device to hold the implant at at least one additional angular position.

The present invention discloses a combined semi-limiting multipolar artificial wrist joint, or semi-limiting bipolar artificial wrist joint, and be selected and assembled based on the specific pathological conditions of wrist bone destruction. For instance, the metacarpal bone articular surface is shown to be complete and the bone quality is good, and most of the far carpal bones (including small polyangular bones and head bones) can be preserved, while the proximal carpal bones (scaphoid and lunate) and the articular surface of the carpal radius are broken, and the proximal carpal bones are to be excised. The artificial wrist joint can also be assembled in another way, which is called semi-limiting multipolar artificial wrist joint, wherein the pathologically damaged double carpal bones are excised to form an inter-matching assembly of palm, wrist and radius joints.