A unique, universal Zero-Profile Expandable Intervertebral Spacer (ZP-EIS) device for fusion and distraction throughout the entire spine is provided which can be inserted via anterior, anterolateral, lateral, far lateral or posterior surgical approaches dependent on the need and preference. Multiple ZP-EIS embodiments each with unique mechanisms of calibrated expansion are provided. Two of these embodiments incorporate bi-directional fixating transvertebral (BDFT) screws and five other embodiments do not incorporate BDFT screws. A tool for implantation into the intervertebral device and calibrated device expansion is also disclosed.

A spinal implant device has a synthetic or metallic or a combination thereof of these materials in an implant body structure and stem cells in a coating, or a sheet, wrap or a membrane wrap applied to surfaces on the implant body structure or alternatively filled with a plug of stem cell laden material. The implant body structure preferably has an aperture or channel The spinal implant device may include anchoring holes to secure the device to the spinal skeletal structure with fasteners or alternatively can simply be held in place by and between adjacent vertebrae.

An intervertebral implant can include a core and a flexible end plate. The core can have a core body that is elongate along a first direction and defines first and second outer surfaces. The flexible end plate can define an inner surface and an opposed bone facing surface that is configured to abut a vertebral body. The flexible end plate can be coupled to the core such that at least a portion of the inner surface faces the first outer surface and is spaced from the first outer surface. The flexible end plate is configured to resiliently flex toward a compressed configuration such that as the flexible end plate flexes toward the compressed configuration, a first end moves relative to the core along the first direction and the portion of the inner surface moves toward the first outer surface.

A spine implant for an ALIF procedure includes anchoring members being either a bone screw or flexible barb, each having a head on one end of a shaft, and a tip on another end of the shaft. The spine implant includes a porous cage having a front, rear, central cavity, and three angled bores in the front that extend into the central cavity configured to receive one of the plurality of anchoring members such that the tip of the anchoring member extends from one or another side of the cavity with its head retained in the front. The spine implant further includes two retention members configured for insertion into the front such that a portion of the two retention members are positioned over the heads of two, adjacent anchoring members to inhibit bone anchor backout via cam action between the retention member and the heads of the anchoring members.

An implant includes a first support, a second support rotatably coupled to the first support along a distal end of the implant, and a control assembly configured to move the implant between at least a first, collapsed orientation and a second, expanded orientation, the control assembly includes a control driver coupled to the first support and comprising a head and a shaft, the control driver configured to control relative movement between the first support and the second support, a control member configured to move along the shaft of the control driver, and a first linkage hingedly coupled to the control member and the second support, wherein movement of the control member causes the first support to move relative to the second support.

The invention provides a method of making a biological disc graft. In one embodiment, the biological disc graft is useful for treating back or neck pain. In one embodiment, the biological disc graft is useful for treating any joint pain. The invention also provides a method of implanting said biological disc graft in a way that is minimally invasive and less dangerous.

Intersomatic cage for vertebral stabilization, including a generally prismatic body consisting of surface receptacles containing slow prolonged release substances selected from the classes of anti-inflammatory, anti-infection and bone regrowth promoter drugs. The receptacles are in the form of gratings of grooves.

Intersomatic cage for vertebral stabilization, including a generally prismatic body having an outer rigid framework in the form of a truss within which at least one insert incorporating slow prolonged release substances selected from the classes of anti-inflammatory, anti-infection and bone regrowth promoter drugs is housed.

The present invention disclosed a method of producing a three-dimensional porous tissue in-growth structure. The method includes the steps of depositing a first layer of metal powder and scanning the first layer of metal powder with a laser beam to form a portion of a plurality of predetermined unit cells. Depositing at least one additional layer of metal powder onto a previous layer and repeating the step of scanning a laser beam for at least one of the additional layers in order to continuing forming the predetermined unit cells. The method further includes continuing the depositing and scanning steps to form a medical implant.

An expandable interbody fusion device and an associated instrument for inserting the device into an intervertebral disc space, expanding the device and for use in delivering graft material into the device once expanded in the disc space. The device is small enough to fit through Kambin's triangle yet is capable of expanding both in the vertical direction to accommodate spinal lordosis and in the lateral direction to provide sufficient structural support for opposing vertebral bodies laterally within the disc space. A process of forming textured top and bottom surfaces of the device by initially laser ablating each surface with a nano-second pulsed laser followed by laser ablating those surfaces with a femto-second pulsed laser.