Hard-tissue implants are provided that include a bulk implant, a face, pillars, slots, and at least one support member. The pillars are for contacting a hard tissue. The slots are to be occupied by the hard tissue. The at least one support member is for contacting the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1. Methods of making and using hard-tissue implants are also provided.

An augment device for a joint endoprosthesis, the device including a sleeve surrounding a channel extending through the sleeve. The sleeve is formed of porous material for ingrowth of bony material, the sleeve comprising an inner face and an outer face. The sleeve further comprises a wall surrounding the channel, the wall being made of solid material and forming a sandwich structure with the porous material, wherein the wall forms a bulkhead between the inner face and the outer face. Thereby, the bulkhead wall will stop inflow of any cement across the sleeve from its inner to its outer face. The porous material on the outer face will be kept free from cement and its capability to promote bone ingrowth is reliably preserved. The augment devices are preferably provided as a set having different sizes and straight or stepped bottoms for improved versatility and maximum preservation of natural bone matter.

A bone implant includes a main body in the form of a hollow body open on both sides in the axial direction. The main body includes a load-bearing material. An encasing body at least partially encases the main body on the outside and includes an in vivo degradable/in vivo resorbable material. Alternatively, the encasing body includes a multiplicity of shaped bodies protruding from the main body in the radial direction that include an in vivo degradable/in vivo resorbable material. A method for producing the bone implant includes an additive manufacturing process. The main body can be at least partially encased by the encasing body in the additive manufacturing process.

Methods and devices for correcting wear pattern defects in joints. The methods and devices described herein allow for the restoration of correcting abnormal biomechanical loading conditions in a joint brought on by wear pattern defects, and also can, in embodiments, permit correction of proper kinematic movement.

A prosthesis for a mammal comprises a prosthesis body (302) with a dorsal surface (311) and a ventral surface (312) shaped to fit in a joint between a tibia and a femur so that the dorsal surface faces a distal end of the femur and the ventral surface faces a proximal end of the tibia. At least one fixation element (303) is provided for fixing the prosthesis body (302) to the tibia (150), wherein the dorsal surface (311) is inclined in a dorsal direction towards a caudal edge of the prosthesis body, to stabilize the femur.

Provided herein are biomimetic osteochondral implants that are generally useful for the at least partial resurfacing of damaged cartilage within a joint. The implants are constructed to have a modular, layered structure in which the physical properties (e.g., stiffness and lubricity) or dimensions of each layer can be adjusted (e.g., by using the appropriate material and controlling the thickness thereof) based on the anatomy to be replaced. For example, the material and or thicknesses of the layers can be selected to approximate the physical properties and/or dimensions of cartilage (and, optionally, chondral and subchondral bone). Also provided herein are methods of treatment involving the use of said biomimetic osteochondral implants to repair an osteochondral defect in a joint.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

An augment device for a joint endoprosthesis, the device including a sleeve surrounding a channel extending through the sleeve. The sleeve is formed of porous material for ingrowth of bony material, the sleeve comprising an inner face and an outer face. The sleeve further comprises a wall surrounding the channel, the wall being made of solid material and forming a sandwich structure with the porous material, wherein the wall forms a bulkhead between the inner face and the outer face. Thereby, the bulkhead wall will stop inflow of any cement across the sleeve from its inner to its outer face. The porous material on the outer face will be kept free from cement and its capability to promote bone ingrowth is reliably preserved. The augment devices are preferably provided as a set having different sizes and straight or stepped bottoms for improved versatility and maximum preservation of natural bone matter.

Certain embodiments generally provide an improved tibial base member comprising keel portions that allow one or both cruciate ligaments to be preserved. Other embodiments provide improved lateral and/or medial inserts having a mesial lip that helps relieve and or prevent impingement between the femoral component and the tibial eminence. Other embodiments provide improved femoral components having various chamfers to provide additional clearance with respect to the tibial eminence and posterior cruciate ligament without decreasing bone coverage.

The glenoid implant described here addresses wear of the implant's portion which articulates with a humeral head, and also addresses a frequent need to reverse the normal glenoid and humeral articulating surfaces. The new glenoid implant provides a coupling portion between the implant's bone fixation portion, which joins the implant to the glenoid bone, and the implant's articulating portion which articulates on an opposing humeral head. The coupling portion is joined to the bone fixation portion firmly but is disengageable without requiring the bone fixation portion's replacement so that the articulating portion can be removed from the implant and replaced without changing either the coupling portion or the bone fixation portion.