A prosthetic total knee replacement system comprises a distal femoral implant component, a tibial tray implant component and a fixed bearing tibial tray insert. The fixed bearing tibial tray insert is fixed to the tibial tray and articulates with the distal femoral implant component. The fixed bearing tibial tray insert component has a medial-lateral centerline and a stabilizing post. The stabilizing post has a medial-lateral centerline offset laterally from the medial-lateral centerline of the fixed bearing tibial tray insert.

A method of preparing an interpositional implant suitable for a knee. The method includes determining a three-dimensional shape of a tibial surface of the knee. An implant is produced having a superior surface and an inferior surface, with the superior surface adapted to be positioned against a femoral condyle of the knee, and the inferior surface adapted to be positioned upon the tibial surface of the knee. The inferior surface conforms to the three-dimensional shape of the tibial surface. The implant may be inserted into the knee without making surgical cuts on the tibial surface. The tibial surface may include cartilage, or cartilage and bone.

An implant for filling a bore hole in a bone includes: a biocompatible plate having upper and lower surfaces; and a support frame having a central portion located at least partially within the plate, an outer rim having a plurality of fastening points adapted for attaching the implant to bone surrounding a bore hole in which the plate is inserted, and a plurality of arms extending between the central portion and the outer rim.

This invention related to a method of forming a polymer component and comprises blending polymer particles with antioxidant to form a mixture in which the antioxidant coats the polymer particles, irradiating the polymer particles to cross-link the polymer particles therein and forming the irradiated mixture into a consolidated component. The invention also relates to a method of forming an articular surface for a prosthesis and a prosthesis having a polymer articular bearing surface wherein at least one predetermined portion of the bearing surface is provided with cross-linked polymer bonds.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

Hard-tissue implants are provided that include a bulk implant, a face, pillars, slots, and at least one support member. The pillars are for contacting a hard tissue. The slots are to be occupied by the hard tissue. The at least one support member is for contacting the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1. Methods of making and using hard-tissue implants are also provided.

A prosthetic total knee replacement system comprises a distal femoral implant component, a tibial tray implant component and a fixed bearing tibial tray insert. The fixed bearing tibial tray insert is fixed to the tibial tray and articulates with the distal femoral implant component. The fixed bearing tibial tray insert component has a medial-lateral centerline and a stabilizing post. The stabilizing post has a medial-lateral centerline offset laterally from the medial-lateral centerline of the fixed bearing tibial tray insert.

Certain embodiments generally provide an improved tibial base member comprising keel portions that allow one or both cruciate ligaments to be preserved. Other embodiments provide improved lateral and/or medial inserts having a mesial lip that helps relieve and or prevent impingement between the femoral component and the tibial eminence. Other embodiments provide improved femoral components having various chamfers to provide additional clearance with respect to the tibial eminence and posterior cruciate ligament without decreasing bone coverage.

A multi-layered prosthetic element comprises a central body (1; 1) of a substantially truncated conical shape and having a through axial cavity (2; 2) open at both ends which gives the central body (1; 1) a ring-shaped cross-section. The central body (1, 1) comprises an outer portion (110; 110), made of trabecular metal material, an inner portion (130; 130), made of trabecular metal material, and an intermediate portion (120; 120) made of metal material without significant porosity. The outer portion (110; 110) and the inner portion (130; 130) are integrally connected to the intermediate portion (120; 120). The intermediate portion (120; 120) is configured to mechanically resist to stresses transmitted to the inner portion (130; 130) on one side and to the outer portion (110; 110) on the other side.

The invention relates to a femoral component (1) of a knee replacement assembly. The knee replacement assembly is arranged to articulate about an articulation axis (X). The femoral component comprises an outer surface (100), wherein the outer surface is arranged to define a replacement condyle; and an inner surface (200), opposed to the outer surface, wherein the inner surface is adapted for attachment to a prepared distal femur. The inner surface comprises portions (210, 220, 230, 240) provided with mutually-parallel ridges (201) and grooves (202). The ridges and grooves are arranged to provide an increased or reduced stiffness of the femoral component when cantilevered about the articulation axis compared with a stiffness of the femoral component when cantilevered about a transverse axis.