An orthopaedic implant includes a support body with a first side having a first inner surface and a second side connected to the first side and having a second inner surface and an outer surface. The first inner surface and the second inner surface each have channels formed within that combine to form a reservoir within the support body. A bone ingrowth layer is attached to the outer surface of the second side.

A spinal fixation device includes an outer housing and an end plate assembly coupled with the outer housing. The outer housing defines an aperture and a longitudinal axis. At least a portion of the end plate assembly is slidably received within the outer housing. The end plate assembly includes a first end plate configured to engage a vertebral body, wherein the end plate assembly is selectively movable between a first position in which the first end plate is spaced apart from the outer housing and a second position in which the first end plate is adjacent the outer housing. Further, the first end plate is selectively adjustable to an angular orientation of a plurality of angular orientations with respect to the longitudinal axis of the outer housing.

A spacer for a knee replacement prosthesis. The spacer may have a lower surface with a locking component adapted to interlock with a tibial tray, an upper surface optionally with a tibial post and a pair of smooth-surfaced and slightly concave condyle support platforms disposed on opposite sides of the tibial post, and a substantially hollow body with an internal reservoir that can be filled with antibiotic material. The reservoir may be accessible from a port on the hollow body that leads into the internal reservoir, and which permits refilling of the reservoir. In some embodiments, the reservoir may be refillable from this port without removal of the spacer from the patient; for example, a percutaneous needle may be inserted into the port. The spacer may dispense antibiotic from this reservoir to the surrounding area in order to treat an infection.

A prosthetic disc can take the form of a sensing artificial disc that includes a resilient core and at least one sensor configured to sense one or more conditions within and/or experienced by the disc. The sensing artificial disc can serve as a replacement to a failed or injured disc between two vertebrae of a spine. The sensing artificial disc can include at least one element configured to change a condition or property of the resilient core in response to a condition sensed by the at least one sensor. A prosthetic disc can include therapeutic system configured to deliver medication to the body, which can include a reservoir of medication.

A reinforced surgical membrane for supporting bone growth by shielding a bone cavity from soft tissue in-growth comprises are a reinforcing layer (2) between a first membrane layer and a second membrane layer (4). The reinforcing layer (2) has defined therein an array of holes (3) which may connect the first and second membrane layers.

An antibiotic delivery system including an intramedullary stem that is adapted to be removably mounted into a medullary canal of a bone. The stem includes a body having an inlet adapted to be in fluid communication with a source of liquid-borne antibiotic and a plurality of outlets disposed along the stem. A channel extends between the inlet and the plurality of outlets for delivering a fluid-borne antibiotic from the inlet to the plurality of outlets so as to distribute the antibiotic along the medullary canal in a controlled fashion. A method of treating an infected joint during a two-stage re-implantation of an orthopedic implant is also disclosed.

A prosthetic device, adapted to be implanted in the human body and adapted to prevent and/or treat an infection that can arise and/or which has arisen at a bone site or at an articular site, wherein the prosthetic device has a prosthetic body provided with at least one surface for coupling, during use, with the bone or articular site and with at least one cavity placed along the coupling surface, wherein the at least one cavity is adapted to include, contain or house at least one pharmaceutical or medical substance.

A method of revising a patient having a fusion cage implanted within a spinal column, involving percutaneously delivering a first end of a tube to the spinal column, fluidly connecting the first end of the tube to the fusion cage, and delivering a bone growth agent into the fusion cage through the tube.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

An orthopedic screw includes a main body having a torqueing end, an inner chamber formed therein, and at least two mating features separated by a separation gap, the separation gap extending into the inner chamber, at least one of the at least two mating features having a first tapered portion with an increasing width and a second tapered portion with a decreasing width; and a support member removably placed in the inner chamber of the main body and having a support portion at least partially filling the separation gap between the at least two mating features.