Compositions and method of manufacturing carboxypolysaccharides (CPS) including carboxymethyl cellulose (CMC) and polyethylene glycols (PEGs) are provided where the PEG is a PEG-epoxide covalently linked to the CPS. In certain embodiments, the PEG attaches to only one CPS, forming a decorated CPS. In other embodiments, the functional groups of a bi-functional PEG molecule (PEG diglycidyl ether) are attached to different CPSs, thereby forming a covalently cross-linked composition. Such compositions can be used as space-filling materials, load-bearing materials, anti-adhesion compositions, drug delivery vehicles, and lubricants of tissues and medical instruments.

An orthopedic implant system includes an orthopedic implant having an articulating component with an articulating surface and an interface surface opposed to the articulating surface, and a body component connected to the interface surface and having a bore formed therein, the bore having at least one lip; and an orthopedic screw connected to the orthopedic implant, the orthopedic screw including a main body having a torqueing end, an inner chamber formed therein, and at least two mating features separated by a separation gap, the separation gap extending into the inner chamber and at least one of the at least two mating features abutting against the at least one lip, and a support member removably placed in the inner chamber of the main body and having a support portion at least partially filling the separation gap between the at least two mating features.

A prosthetic device, adapted to be implanted in the human body and adapted to prevent and/or treat an infection that can arise and/or which has arisen at a bone site or at an articular site, wherein the prosthetic device has a prosthetic body provided with at least one surface for coupling, during use, with the bone or articular site and with at least one cavity placed along the coupling surface, wherein the at least one cavity is adapted to include, contain or house at least one pharmaceutical or medical substance.

An orthopaedic screw includes a main body having a torqueing end, an inner chamber formed therein, and at least two mating features separated by a separation gap, the separation gap extending into the inner chamber, at least one of the at least two mating features having a first tapered portion with an increasing width and a second tapered portion with a decreasing width; and a support member removably placed in the inner chamber of the main body and having a support portion at least partially filling the separation gap between the at least two mating features.

The invention primarily relates to fastening and stabilizing tissues, implants, and/or bondable materials, such as the fastening of a tissue and/or implant to a bondable material, the fastening of an implant to tissue, and/or the fastening of an implant to another implant. This may involve using an energy source to bond and/or mechanically to stabilize a tissue, an implant, a bondable material, and/or other biocompatible material. The invention may also relate to the use of an energy source to remove and/or install an implant and/or bondable material or to facilitate solidification and/or polymerization of bondable material.

Provided is a functional, low-profile intercranial device (LID). The LID includes a base portion; at least one cavity associated with the base portion and configured to accept at least one functional component; and at least one conduit having a first end in communication with the at least one cavity. The at least one functional component includes a medicinal, electronic, or optic therapeutic. The at least one conduit is configured to accept the medicinal therapeutic and a second end configured to dispense the therapeutic.

The present invention provides a porous composite the connected structure, method and prosthetic implant for sensor detection and drug delivery, where the porous structure is pre-connected or integrally formed with an intermediate to obtain a composite, which is connected to the substrate so that the porous structure covers the surface of the substrate. The present invention realizes the effective connection of a porous structure and a substrate, satisfying the connection requirements when the overall properties of the mechanical structure and its surface properties differ, and avoids the problem that the mechanical properties of the substrate could be greatly reduced by processes such as hot pressing. The connected structure of the present invention is provided with at least one holding space in which sensors can be placed to detect the status of the interior and exterior of the connected structure as needed, and in which drugs can also be placed and released according to the need for prevention or treatment, broadening the application scopes of the connected structure.

A spinal fixation device includes an outer housing and an end plate assembly coupled with the outer housing. The outer housing defines an aperture and a longitudinal axis. At least a portion of the end plate assembly is slidably received within the outer housing. The end plate assembly includes a first end plate configured to engage a vertebral body, wherein the end plate assembly is selectively movable between a first position in which the first end plate is spaced apart from the outer housing and a second position in which the first end plate is adjacent the outer housing. Further, the first end plate is selectively adjustable to an angular orientation of a plurality of angular orientations with respect to the longitudinal axis of the outer housing.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

An orthopaedic implant includes an internal fixation device. The internal fixation device includes: an exterior surface; a threaded section including a reservoir and at least one threaded section channel fluidly communicating the reservoir with the exterior surface, each threaded section channel having an interior diameter and a length which is greater than the interior diameter; a head including a head channel fluidly communicating the reservoir with an exterior surface of the head, a channel diameter of the head channel being respectively larger than a largest interior diameter of each threaded section channel, the channel diameter of the head channel being the same as a large interior diameter of the reservoir; and a continuously tapering inner surface between the head channel and the reservoir.