Provided herein are devices and methods for treating inflammation and pain of articular joints (e.g., the knee). An implantable device includes an elongate body extending from a proximal end to a distal end, a flange disposed at the proximal end, a bore extending from an opening at the proximal end into the elongate body, one or more fixation members disposed on an outer surface of the elongate body, and a payload (e.g., a drug-polymer core) having a therapeutic agent disposed within the bore. The payload has a substantially constant surface area on an exposed portion throughout elution of the therapeutic agent after the implantable device is implanted in a body. The therapeutic agent is configured to elute using zero-order kinetics, constantly and continuously at an amount that is above a predetermined lower threshold and does not exceed a predetermined upper threshold unlike a pulse-dose injection.

Intersomatic cage for vertebral stabilization, including a generally prismatic body consisting of surface receptacles containing slow prolonged release substances selected from the classes of anti-inflammatory, anti-infection and bone regrowth promoter drugs. The receptacles are in the form of gratings of grooves.

A spacer for a knee replacement prosthesis. The spacer may include a lower surface, which has a locking component adapted to interlock with a tibial tray, an upper surface, the upper surface having a pair of condyle support platforms; and a frame positioned therebetween for anchoring the upper and lower surfaces thereto, the frame having a hollowed center defined by internal cavities. In some exemplary embodiments, the spacer may further include a fluid delivery system for localized antibiotic treatment to the surrounding joint. The delivery system may include a reservoir disposed within the internal cavity, a septum operatively connected to the reservoir, and fluid delivery element for dispensing a liquid medicament from the reservoir to the surrounding infection. The fluid delivery system may interact with external components to refill, communicate with, and control the system.

Various embodiments provide systems and methods for repairing or replacing intervertebral discs as a treatment for derangements. Systems and methods may comprise an inter vertebral disc implant for deployment into an intervertebral disc space wherein the nucleus has been at least partially evacuated from the deranged intervertebral disc. The intervertebral disc implant may be intraoperatively and postoperatively filled and/or re-filled with a growth matrix. The intervertebral disc implant may be differentially permeable to the growth matrix to provide directional growth and/or diffusion of the growth matrix to restore height to the intervertebral disc space. Systems and methods may further comprise an implant delivery device for deploying the intervertebral disc implant into the intervertebral disc space.

The present invention provides a method for stabilizing a fractured bone. The method includes positioning an elongate rod in the medullary canal of the fractured bone and forming a passageway through the cortex of the bone. The passageway extends from the exterior surface of the bone to the medullary canal of the bone. The method also includes creating a bonding region on the elongate rod. The bonding region is generally aligned with the passageway of the cortex. Furthermore, the method includes positioning a fastener in the passageway of the cortex and on the bonding region of the elongate rod and thermally bonding the fastener to the bonding region of the elongate rod while the fastener is positioned in the passageway of the cortex.

The invention primarily relates to fastening and stabilizing tissues, implants, and/or bondable materials, such as the fastening of a tissue and/or implant to a bondable material, the fastening of an implant to tissue, and/or the fastening of an implant to another implant. This may involve using an energy source to bond and/or mechanically to stabilize a tissue, an implant, a bondable material, and/or other biocompatible material. The invention may also relate to the use of an energy source to remove and/or install an implant and/or bondable material or to facilitate solidification and/or polymerization of bondable material.

Embodiments may include an attachable fastener, which may include a bondable material that may be secured to the end of an end effector. Vibration may be tuned to occur at a distal end of the fastener. Accordingly, the fastener may be used to generate heat at a distal point of contact. If the contact surface contains bondable material, that material may be softened. If the fastener includes bondable material at the point of contact, that material may also be softened by heat produced by vibration at the contact area. A hard implant or another polymeric material may function as the anvil.

A spinal fixation device includes an outer housing and an end plate assembly coupled with the outer housing. The outer housing defines an aperture and a longitudinal axis. At least a portion of the end plate assembly is slidably received within the outer housing. The end plate assembly includes a first end plate configured to engage a vertebral body, wherein the end plate assembly is selectively movable between a first position in which the first end plate is spaced apart from the outer housing and a second position in which the first end plate is adjacent the outer housing. Further, the first end plate is selectively adjustable to an angular orientation of a plurality of angular orientations with respect to the longitudinal axis of the outer housing.

The invention primarily relates to fastening and stabilizing tissues, implants, and/or bondable materials, such as the fastening of a tissue and/or implant to a bondable material, the fastening of an implant to tissue, and/or the fastening of an implant to another implant. This may involve using an energy source to bond and/or mechanically to stabilize a tissue, an implant, a bondable material, and/or other biocompatible material. The invention may also relate to the use of an energy source to remove and/or install an implant and/or bondable material or to facilitate solidification and/or polymerization of bondable material.

A musculoskeletal stabilization system adapted to stabilize spine and SI joint structures. The musculoskeletal stabilization system includes a spine structure stabilization sub-system and a pelvic structure stabilization sub-system. The pelvic structure stabilization sub-system comprising two multi-function prostheses that are adapted to be delivered to and inserted into SI joints of a subject via a posterior trajectory. The multi-function joint prostheses are further adapted to stabilize respective SI joints and cooperate with the spine stabilization sub-system to also stabilize the subject's spine jointly.