An implant includes an openwork, hollow-cylindrical main body assembled from a plurality of openwork, hollow-cylindrical segments arranged in succession in a longitudinal direction, the segments being connected to one another. The segments included two terminal segments arranged at opposite longitudinal ends of the main body and at least one inner segment between the two terminal segments. Each of the terminal and inner segments has a plurality of bars that form a circumferential meandering structure with maximum points and minimum points. The main body is configured to assume a compressed state and an expanded state.

The meandering structure of at least one of the two terminal segments has a smaller number of minimum points than the at least one inner segment.

A flow modifying apparatus may include a plurality of struts coupled together to form a radially expandable frame having a proximal end and a distal end. The proximal and distal ends may be radially expandable into expanded proximal and distal ends. A reduced diameter portion of the expandable frame may be disposed between the expanded proximal and distal ends and the reduced diameter portion may comprise a fluid flow through passage. A cover may be disposed over at least a portion of the radially expandable frame. The reduced diameter portion modifies fluid flow therethrough immediately upon implantation thereof and forms a pressure gradient between the inflow end and the reduced diameter portion.

A system for treating a bifurcation includes first and second delivery catheters. The first catheter has a first shaft, a first expandable member adjacent the distal end of the first shaft, an auxiliary expandable member disposed under the first expandable member, and a first radially expandable stent disposed over both the first expandable member and the auxiliary expandable member. The second delivery catheter has a second shaft, and a second expandable member adjacent the distal end of the second shaft. A portion of the second catheter is disposed under a portion of the first stent, and a portion of the second delivery catheter passes through a side hole in the first stent. The first stent is crimped over the first and second catheters such that the first stent remains attached to the first and the second catheters during advancement of the catheters through a blood vessel.

A stent graft; the stent graft is provided in the axial direction thereof with at least one Region T, and the Region T includes a plurality of wavy rings; in the circumferential direction, the Region T includes a region A and a Region B that is connected to the region A, the ratio of the area of the region A to the area of the Region T being 1/4-2/3, the ratio of the coverage rate of the wavy rings in the region A to the coverage rate of the wavy rings in the Region B being 1/5-9/10, and the ratio of the coverage rate of the wavy rings within any circular region having a diameter of 20 mm within the region A to the coverage rate of the wavy rings in the region A being 0.7-1.3.

A stent in a radially compressed configuration includes a plurality of first outer crowns and a plurality of second outer crowns, each of the first outer crowns and the second outer crowns connected by a strut of a plurality of struts. The plurality of first outer crowns and the plurality of second outer crowns are disposed at a crown angle in the range of about 15 degrees to about 35 degrees, the crown angle being defined by a line extending through a midpoint of a crown of the plurality of first outer crowns or the plurality of second outer crowns through a center of radius of the crown with respect to a line that is parallel to a central longitudinal axis of the stent.

Apparatus and methods are described including inserting an implantable device (20) into a blood vessel of a subject while the implantable device is disposed inside a delivery device and is constrained in a constrained configuration by the delivery device. The implantable device is released from the delivery device into the blood vessel, thereby causing the implantable device to assume a non-constrained configuration by an upstream end of the implantable device radially expanding (120), a central portion (122) of the implantable device radially expanding such that along the central portion of the implantable device the inner surface (24) of the implantable device defines a diverging portion (25) of a conduit (26), and the implantable device forming a folded portion (128) between the upstream end of the implantable device and the central portion of the implantable device. Other applications are also described.

Apparatus and methods are provided for treating patients exhibiting symptoms of hypertension, isolated systolic hypertension, heart failure with preserved ejection fraction, May-Thuner Syndrome or dyspnea by diagnosing and reducing narrowing of a patient's iliac vein caused by extrinsic localized compression using a stent having circumferential differential radial stiffness and delivery catheter for aligning and deploying such stents.

According to various aspects and embodiments, a growth adaptive expandable stent is provided. The expandable stent includes a stent structure having a cylindrical shape that is self-expanding in a radial direction and includes a plurality of cylindrical rings disposed along a longitudinal axis of the stent structure. The stent structure is configured to exert a continuous outward radial force over time when implanted such that a diameter of the stent structure expands from a first value to a second value that is at least about 1.5 times the first value.

A device for modifying blood flow through a target artery of a patient is described. A method for treating obesity in a patient includes positioning the device in a first artery to decrease blood flow through a second artery causing hypoperfusion to a gastrointestinal organ serviced by the second artery, and interfering with gastrointestinal function to induce weight loss. A system for placement of a blood flow modification device within a first artery to gradually reduce blood flow to a second target artery while maintaining blood flow to the first artery is also provided. The device may be modifiable after treatment to restore or increase blood flow to the artery.

A shunt is described that expands to an hourglass shape. As the shunt expands, both of its ends radially flare outwards relative to its middle section and the length of the shunt foreshortens, which causes the flared ends to engage the tissue surrounding a puncture or aperture within a patient's tissue.