In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.

The present invention provides a patch preparation comprising lidocaine or a salt thereof, lactic acid, and a hydroxy acid having 4 to 6 carbon atoms, wherein the amount of lactic acid is 0.6 to 1.2 moles per mole of lidocaine or a salt thereof with high safety which can continuously produce the therapeutic effect of lidocaine for a long time by adjusting the skin penetration rate of lidocaine to a proper range when applied to the skin and also show the similar bioequivalence to the existing preparations comprising lidocaine even when high concentration of lidocaine is used.

Provided is a dexmedetomidine-containing non-aqueous external preparation being capable of suppressing the precipitation of a crystal of dexmedetomidine in the preparation, and having satisfactory transdermal absorbability. The non-aqueous external preparation includes: (A) dexmedetomidine or a salt thereof; (B) an aliphatic alcohol having 10 to 12 carbon atoms; (C) a propylene glycol monoester of a fatty acid having 6 to 16 carbon atoms; (D) an organic acid; and (E) an organic acid salt.

The present invention is directed to a transdermal delivery device comprising ketamine and formulations thereof. The present invention is also directed to a transdermal delivery device comprising ketamine for the treatment of major depressive disorder (MDD) and/or pain. The present invention is further directed to a transdermal delivery device comprising ketamine and abuse deterrent agents.

I disclose a patch, comprising a film having a first surface and a second surface, wherein the second surface is opposed to the first surface, and a coating on the first surface of the film, wherein the coating comprises a transdermal adhesive and one or more active ingredients. The active ingredient(s) may minimize and/or improve recovery from a hangover. I also disclose methods of using such patches; kits comprising such patches and instructions for their use; and methods of manufacturing such patches.

A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains a mixture of a pharmaceutically acceptable acid addition salt of ropinirole and potassium hydrogen carbonate, and the mixture contains at least one selected from the group consisting of ropinirole and pharmaceutically acceptable acid addition salts thereof and potassium hydrogen carbonate.

The present invention relates to composition of sleep aid transdermal patch comprising natural herbal ingredient as active ingredient, synergistic additives and pharmaceutically acceptable excipients. The present invention relates to composition of transdermal patch comprising valerian as natural herbal ingredient, skullcap, licorice, passionflower as synergistic additives and pharmaceutically acceptable excipients to aid sleep in insomnia conditions. The present invention also relates to an efficient process for the preparation of sleep aid transdermal patch by using hot-melt coating technique (HMC), comprising the steps of melting, mixing, coating, laminating and cutting.

The present invention relates to a transdermal therapeutic system for the cutaneous administration of phenprocoumon, comprising an active-substance-impermeable backing layer, an adhesive matrix layer and optionally a removable protective layer, the adhesive matrix layer containing phenprocoumon and at least one matrix polymer, and the content of phenprocoumon in the matrix polymer being ≤7.5 wt. %. By virtue of the low load, it is ensured that the system releases the active ingredient substantially in high release rates, because high thermodynamic activity of the active ingredient is achieved. The present invention also relates to a method for producing a corresponding transdermal therapeutic system.

The present invention relates to a transdermal therapeutic system (TTS) for the transdermal administration of asenapine comprising a self-adhesive layer structure comprising a therapeutically effective amount of asenapine, said self-adhesive layer structure comprising: A) a backing layer; B) an asenapine-containing layer comprising: 1. asenapine in the form of the free base; and 2. a polymer selected from the group consisting of polysiloxanes and polyisobutylenes in an amount of more than 50% by weight based on the total weight of the asenapine-containing layer; and C) optionally an additional skin contact layer.

Described herein are examples of patches which include a hydrogel having an active homeopathic ingredient dissolved therein. The active homeopathic ingredient Berberis vulgaris is dissolved in the hydrogel and is effective at treating molluscum contagiosum. The patches are cured and shaped so that the active ingredient kills the virus over time when the patch is in contact with an infected area. The patches temporarily adhere to the skin and are effective at curing and preventing the spread of viral skin infection, both to other people and to other parts of the infected person's body. The patches may be packaged and sold as an over-the-counter homeopathic product.