This application describes compounds and methods that can be used to treat, reverse, or avoid hyperalgesia.

This application describes compounds and methods that can be used to treat, reverse, or avoid hyperalgesia.

An object of the present invention is to provide a compound useful as an anti-tumor agent or the like; an intermediate thereof; and a pharmaceutical composition, an anti-tumor agent, and a dihydroorotate dehydrogenase inhibitor, each of which contains the compound. According to the present invention, there is provided a compound represented by General Formula (1) or a salt thereof:

##STR00001## in the formula, Z.sup.1, Z.sup.2, and Z.sup.3 are the same as or different from each other and represent a nitrogen atom or CH; Z.sup.4 represents a nitrogen atom or a general formula of CR.sup.6; Z.sup.5 represents a nitrogen atom or a general formula of CR.sup.7 provided that at least one of Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4, or Z.sup.5 represents a nitrogen atom; R.sup.1 represents a general formula of CONHR.sup.8 or the like; R.sup.2 represents a C.sub.3-8 cycloalkyl group which may be substituted or the like; R.sup.3, R.sup.5, R.sup.6, and R.sup.7 are the same as or different from each other and represent a hydrogen atom, a halogen atom, or the like; R.sup.4 represents an aryl group which may be substituted or a heterocyclic group which may be substituted; R.sup.8 represents a general formula of SO.sub.2R.sup.9 or the like; and R.sup.9 represents an amino group which may be protected or the like.

There are provided inter alia compounds capable of inhibiting retinal pigment epithelium (RPE) degeneration or geography atrophy (GA) associated with age-related macular degeneration (AMD), and methods of using the same.

The present invention relates to an agent for killing HIV-1-infected cells, comprising a compound represented by formula (I):

##STR00001##

wherein Ar.sup.1 and Ar.sup.2 are the same or different and represent a substituted or unsubstituted aromatic group, and X represents —CH.sub.2O— or —CH═CH—, its salt, or their solvate, and a combined preparation for simultaneous, separate, or sequential administration in treating or preventing HIV-1 infection, comprising two separate preparations: (a) a preparation comprising a compound represented by the formula (I), its salt, or their solvate, and (b) a preparation comprising an anti-HIV-1 drug.

The present invention relates to an agent for killing HIV-1-infected cells, comprising a compound represented by formula (I):

##STR00001##

wherein Ar.sup.1 and Ar.sup.2 are the same or different and represent a substituted or unsubstituted aromatic group, and X represents —CH.sub.2O— or —CH═CH—, its salt, or their solvate, and a combined preparation for simultaneous, separate, or sequential administration in treating or preventing HIV-1 infection, comprising two separate preparations: (a) a preparation comprising a compound represented by the formula (I), its salt, or their solvate, and (b) a preparation comprising an anti-HIV-1 drug.

A spot-on pesticide composition for animals, specifically mammals, including dogs and cats, which composition comprises fipronil, etofenprox, and an insect growth regulator as the active components, in doses and proportions which are effective against a variety of insects and pests, and in a formulation which is convenient for local application to the animal's skin, preferably localized over a small surface area.

A spot-on pesticide composition for animals, specifically mammals, including dogs and cats, which composition comprises fipronil, etofenprox, and an insect growth regulator as the active components, in doses and proportions which are effective against a variety of insects and pests, and in a formulation which is convenient for local application to the animal's skin, preferably localized over a small surface area.

A spot-on pesticide composition for animals, specifically mammals, including dogs and cats, which composition comprises fipronil, etofenprox, and an insect growth regulator as the active components, in doses and proportions which are effective against a variety of insects and pests, and in a formulation which is convenient for local application to the animal's skin, preferably localized over a small surface area.

A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I):

##STR00001##

or a pharmaceutically acceptable salt thereof.