The present invention relates to an emulsion composition for chemoembolization comprising a nanoparticle comprising a drug and a biocompatible polymer, a water-soluble contrast agent and a water-insoluble contrast agent, and a water-insoluble drug as well as an aqueous drug can be administered in a form of stable emulsion, and drugs are slowly released, thereby enhancing the effect of chemoembolization.

Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases diseases characterized by aberrant DLL4 and/or VEGF expression or activity.

Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases diseases characterized by aberrant DLL4 and/or VEGF expression or activity.

The invention relates to pharmaceutical compositions comprising at least one inhibitor of a histon-deacetylase (HDACi) and at least one agonist of Toll-like-receptor 7 and/or 8 (TLR7 and/or TLR8). The invention further relates to the aforementioned pharmaceutical compositions for use in a method of treating or preventing a disease. The invention further relates to the aforementioned pharmaceutical compositions for use in a method of treating or preventing cancer. The invention further relates to a method of treating or preventing cancer. The invention further relates to a kit of parts comprising at least one inhibitor of a histon-deacetylase (HDACi) and at least one agonist of Toll-like-receptor 7 and/or 8 (TLR7 and/or TLR8). The invention further relates to a cancer cell contacted with the pharmaceutical composition of the invention, wherein said cancer cell has an upregulated expression of one or more single-stranded RNA (ssRNA) genes, wherein the one or more ssRNA genes with upregulated expression are preferably endogenous retroviral (HERV) genes. The invention further relates to an in vitro method for contacting cancer cells with the pharmaceutical composition of the invention. The invention further relates to a population of cancer cells obtainable by the in vitro method of the invention.

The invention relates to pharmaceutical compositions comprising at least one inhibitor of a histon-deacetylase (HDACi) and at least one agonist of Toll-like-receptor 7 and/or 8 (TLR7 and/or TLR8). The invention further relates to the aforementioned pharmaceutical compositions for use in a method of treating or preventing a disease. The invention further relates to the aforementioned pharmaceutical compositions for use in a method of treating or preventing cancer. The invention further relates to a method of treating or preventing cancer. The invention further relates to a kit of parts comprising at least one inhibitor of a histon-deacetylase (HDACi) and at least one agonist of Toll-like-receptor 7 and/or 8 (TLR7 and/or TLR8). The invention further relates to a cancer cell contacted with the pharmaceutical composition of the invention, wherein said cancer cell has an upregulated expression of one or more single-stranded RNA (ssRNA) genes, wherein the one or more ssRNA genes with upregulated expression are preferably endogenous retroviral (HERV) genes. The invention further relates to an in vitro method for contacting cancer cells with the pharmaceutical composition of the invention. The invention further relates to a population of cancer cells obtainable by the in vitro method of the invention.

The invention relates to pharmaceutical compositions comprising at least one inhibitor of a histon-deacetylase (HDACi) and at least one agonist of Toll-like-receptor 7 and/or 8 (TLR7 and/or TLR8). The invention further relates to the aforementioned pharmaceutical compositions for use in a method of treating or preventing a disease. The invention further relates to the aforementioned pharmaceutical compositions for use in a method of treating or preventing cancer. The invention further relates to a method of treating or preventing cancer. The invention further relates to a kit of parts comprising at least one inhibitor of a histon-deacetylase (HDACi) and at least one agonist of Toll-like-receptor 7 and/or 8 (TLR7 and/or TLR8). The invention further relates to a cancer cell contacted with the pharmaceutical composition of the invention, wherein said cancer cell has an upregulated expression of one or more single-stranded RNA (ssRNA) genes, wherein the one or more ssRNA genes with upregulated expression are preferably endogenous retroviral (HERV) genes. The invention further relates to an in vitro method for contacting cancer cells with the pharmaceutical composition of the invention. The invention further relates to a population of cancer cells obtainable by the in vitro method of the invention.

Described herein are materials and methods for the treatment of neurodegenerative diseases by administering a combination of fenofibrate and kaempferol.

Described herein are materials and methods for the treatment of neurodegenerative diseases by administering a combination of fenofibrate and kaempferol.

The present invention provides a novel technology useful for a cancer vaccine therapy, that is, a pharmaceutical composition wherein a Toll-like receptor agonist, LAG-3 protein, a variant thereof or a derivative thereof, at least one immunogenic agent, and an immune checkpoint inhibitor are administered in combination.

The present invention provides a novel technology useful for a cancer vaccine therapy, that is, a pharmaceutical composition wherein a Toll-like receptor agonist, LAG-3 protein, a variant thereof or a derivative thereof, at least one immunogenic agent, and an immune checkpoint inhibitor are administered in combination.