The present invention utilizes patient-specific landmarks in order to treat headache pain. In one aspect, the present invention relates to the administration of Clostridial toxins, such as a botulinum neurotoxin, to a patient suffering from a headache pain, where the location of administration of the botulinum toxin is based upon at least one suture line of the patient's skull.

A therapeutic toxin dosage form for treating a disease, disorder, or condition in a subject can include a microneedle array and a therapeutically effective amount of a therapeutic toxin loaded to the microneedle array for administration to the subject. Additionally, a method of treating a disease, disorder, or condition in a subject can include administering a therapeutically effective amount of a therapeutic toxin to the subject via a microneedle array.

Provided herein are MD Codes, MD DYNA Codes, MD ASA, and Next Human system, and the methods of using them to diagnose and treat aesthetic conditions or disorders.

The present invention relates a botulinum toxin prefilled syringe system with desirable injection force characteristics, in particular low gliding force and low break loose force, comprising a syringe barrel of glass containing a liquid botulinum toxin composition, a plunger stopper and a closure device such as a tip cap or a needle shield. In addition, the present invention relates to a kit comprising the botulinum toxin prefilled syringe system, and optionally instructions for use, and to the use of the botulinum toxin prefilled syringe system in therapeutic and cosmetic applications.

This invention relates to novel uses of botulinum neurotoxin in treating a tremor, in particular to a botulinum neurotoxin for use in treating a tremor of the upper limb comprising the administration of a botulinum neurotoxin to at least one muscle of the forearm/wrist, elbow and shoulder, wherein the botulinum neurotoxin is administered to at least one muscle of the forearm/wrist selected from the group of M. extensor carpi ulnaris (ECU), M. extensor carpi radialis (ECR), M. pronator quadratus (PQ) and M. supinator in a dosage in the range of 2 to 6 U and wherein the botulinum neurotoxin is administered to at least one muscle of the elbow in a dosage of about 20 U and to at least one muscle of the shoulder in a dosage of about 15 U.

Pharmaceutical formulations comprising a clostridial derivative and a permeabilizing agent for intravesical instillation are disclosed.

Pharmaceutical formulations comprising a clostridial derivative and a permeabilizing agent for intravesical instillation are disclosed.

A method of treating an obese subject, or a subject having type II diabetes is described. The method includes injecting a therapeutically effective amount of botulinum toxin into the duodenum of the subject. Methods of preventing the development of type II diabetes in subjects such as prediabetic subjects by injection of botulinum toxin are also described.

A cancer therapeutic agent used in combination with an immunotherapeutic agent, for example, an immune checkpoint inhibitor, is disclosed.

A cancer therapeutic agent used in combination with an immunotherapeutic agent, for example, an immune checkpoint inhibitor, is disclosed.