Fluorescent probes for silver ion detection include organic, water-soluble compounds having aggregation-induced emission (AIE) characteristics. The probes can sense or detect silver ions through aggregation or a precipitation reaction between the silver ions and the organic compounds which induces fluorescence. The compounds are acidic, soluble in aqueous phase, and provide low background fluorescence in aqueous solutions.

Provided are a light source unit for an endoscope and an endoscopy system, which clarify the color difference between a first dye and a second dye in an observation image. The light source unit has a white LED light source and a band limiting section. The white LED light source has an excitation light source that emits blue excitation light and a phosphor layer that emits yellow fluorescence upon receipt of the excitation light. As a mixture of the fluorescence and part of the excitation light, the white LED light source outputs light having an intensity spectrum continuous across blue, green and red regions. The band limiting section reduces part of the output light in a wavelength band of not lower than a threshold. The threshold is not less than 650 nm. At the threshold, the first dye (pyoktanin) has an optical reflectance of not less than a constant value, whereas the second dye (indigocarmine) has an optical reflectance of substantially zero.

Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the nanostructure includes a metallic gold surface-enhanced Raman scattering nanoparticle, a Raman reporter and a protection structure. The protection structure may include a thiol-polyethylene glycol to which may be attached a target-specific probe.

The present invention provides an epidermal penetration type ink composition comprising: a fluorescent colorant containing at least one selected from the group consisting of indocyanine green (ICG), cyanine, phthalocyanine, oxazine, rhodamine, and a mixture thereof; a binder resin containing at least one of polyvinylpyrrolidone (PVP) and polyvinylbutyral (PVB); and a solvent containing at least one of ethanol and isopropanol.

A medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also a manufacturing method for the medical tissue-marker. The medical tissue-marker includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an X-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by use of an emulsifier.

Provided are a hydrophilic particle, a method for manufacturing the same, and a contrasting agent using the same. More specifically, the hydrophilic particle according to the inventive concept may include a hydrophobic particle, and an amphiphilic organic dye directly absorbed on a surface of the hydrophobic particle. In this case, the hydrophobic particle includes a center particle, and a hydrophobic ligand covering a surface of the center particle, and the amphiphilic organic dye may be combined to the hydrophobic ligand by a hydrophobic interaction. The hydrophilic particle may have a surface zeta potential lower than a surface zeta potential of the amphiphilic organic dye.

A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible ON-OFF fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. The method includes contacting the cells or tissue with the probe of any one of claims 1-13 and detecting fluorescent intensity of the cell or tissue, wherein increased fluorescent intensity indicates that the cells or tissue is hypoxic. Also provided are a method of synthesizing the compound and a method for synthesizing a therapeutic agent including the compound.

The present application discloses an organic electroluminescent material, a molecular formula thereof is Da--Ac, wherein Da is an aggregation-induced emission group, is a conjugated bond, and Ac is a strong electron-withdrawing group. The organic electroluminescent material of the present application has a simple preparation method, high yield, good thermodynamic stability, can cover the visible region, have excellent electroluminescence effect, and can prepare undoped type of organic electroluminescent devices.

An ophthalmic composition comprising Indigo Carmine, or Indigo Carmine and Trypan Blue, for identification of intraocular structures and membranes within the eye, and methods of delivering and using the same, for surgical treatments of the eye, including glaucoma and cataract surgery.

The present invention relates to the field of medicine, specifically to ophthalmic surgery, more specifically to an improved staining composition for ophthalmic surgery with low toxicity and increased staining efficiency.