The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

Provided herein are libraries of nerve-specific fluorescent contrast agents of substituted 8-methyl-phenoxazine compounds of Formula (I) with excitation and emission profile comparable to US FDA approved methylene blue (MB) and indocyanine green (ICG), respectively, allowing for real-time intraoperative imaging using clinical-grade surgical systems. Also provided 700 nm lead candidates with substantially improved water-solubility, fully negating the need for formulation development with the added advantage of improved safety profiles for patient use in the clinic as well as decreased overall cost of clinical translation.

##STR00001##

The present invention relates to novel amphiphilic dendrimers, hereafter denoted Dendri-TAC. The present invention also relates to perfluorocarbon nanoemulsions stabilized by these amphiphilic dendrimers and their uses for in vivo diagnostic and/or for therapy, notably as theranostic tools, for detection and/or treatment of cancer.

The present invention provides methods and compositions based on optical sensor conjugates that are useful for detecting reactive oxygen, reactive nitrogen, or both species that are a direct result of inflammation caused by tissue damage.

The invention is directed to a staining composition and to the use of the staining composition in staining ocular tissue. In a first aspect, the invention provides a staining composition comprising a vital dye and a density increasing compound chosen from the group consisting of water soluble polymers and small inert molecules.

The present invention provides methods and compositions based on optical sensor conjugates that are useful for detecting reactive oxygen, reactive nitrogen, or both species that are a direct result of inflammation caused by tissue damage.