A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream.

This disclosure relates to a method for determining a fluid balance between a first volume flow in a first section of a fluid circuit and a second volume flow of a second section of the fluid circuit. The method may also include adjusting, assuming or detecting a first temperature in the first section of the fluid circuit and a second temperature in the second section of the fluid circuit, or detecting a temperature difference between the first and the second sections. The method may also include detecting a second volume flow in a second section of the fluid circuit and forming a balance from at least the first volume flow and a corrected value of the second volume flow. The corrected value is determined from the detected second volume flow and the second temperature and/or the temperature difference.

Provided is a temperature-based dialysate regeneration device for regulating a temperature of dialysate discharged from a hemodialyzer to remove uremic toxins and waste therefrom, the temperature-based dialysate regeneration device including: a Joule-Thomson refrigerator, including a compressor, condenser, expander and evaporator, an adsorbent column, and a dialysate heat exchanger in which heat transfer occurs between dialysates. The refrigerant used for the JT refrigerator may be a mixture of two or more refrigerants to enhance the heat transfer generated by the latent heat in the evaporator and the condenser.

A peritoneal dialysis (PD) system includes a housing; a dialysis fluid pump housed by the housing; a dual lumen patient line extending from the housing; a filter set including a final stage filter located along a first line, and which includes a second line in parallel with the first line, the first line in fluid communication with a first lumen of the dual lumen patient line, and the second line in fluid communication with a second lumen of the dual lumen patient line; a pressure sensor located within the housing and positioned so as to sense a static or substantially static PD fluid pressure in the second lumen while fresh PD fluid is pumped through the first lumen and the final stage filter; and a control unit configured to use the sensed static or substantially static pressure in a pressure control routine for the dialysis fluid pump.

A peritoneal dialysis (PD) system includes a housing, a dialysis fluid pump, a dual lumen patient line extending from the housing, and a filter set including a filter located along a first line. A second line of the filter set is parallel with the first line, where the first line is in fluid communication with a first lumen of the dual lumen patient line and the second line is in fluid communication with a second lumen of the dual lumen patient line. The PD system also includes a pressure sensor positioned to sense a static or substantially static negative PD fluid pressure in the first lumen while used PD fluid is pulled through the second lumen of the dual lumen patient line. A control unit is configured to use the sensed static or substantially static negative PD fluid pressure in a pressure control routine for the dialysis fluid pump.

A centrally controlled multi-patient dialysis treatment system (1) as disclosed herein comprises: a dialysate preparation unit (2) configured to prepare a dialysate based on a prescription and control dialysate delivery for dialysis treatments in progress; one or more dialysate modules (3) configured to deliver the dialysate to a dialyzer (4) and control an ultrafiltration process; and one or more patient modules (5) configured to control an extracorporeal blood flow through the dialyzer (4) for the dialysis treatment, wherein the dialysate preparation unit (2), the dialysate modules (3) and the patient modules (5) are configured to be adapted to be assembled into an integrated dialysis treatment system suitable for one or more patients (6). Also an use of the centrally controlled multi-patient dialysis treatment system (1) for one or more patients' dialysis treatments is disclosed herein. For the centrally controlled multi-patient dialysis treatment system, in contrast to the conventional in-center dialysis infrastructures, in addition to cost saving, it is highly space efficient. Moreover, the centrally controlled multi-patient dialysis treatment system is robust and easy to setup.

A system includes an extracorporeal blood treatment device and a heat exchanger for heat exchange between dialysate flowing from the extracorporeal blood treatment device and permeate to be supplied to the extracorporeal blood treatment device. The extracorporeal blood treatment device and the heat exchanger are configured as separate devices.

A peritoneal dialysis system includes a control unit is programmed to cause (i) a pressure sensor to take a first pressure reading of a reference chamber with a pneumatic valve closed, (ii) a pump actuator to pump fresh dialysis fluid through a fresh dialysis fluid pathway into a patient line expandable chamber, expanding the expandable chamber into a dome, (iii) the pneumatic valve to open, allowing the reference chamber to communicate pneumatically with any air in the dome, (iv) the pressure sensor to take a second pressure reading with the pneumatic valve open, (v) the first and second pressure readings to be used with the ideal gas law to determine an amount of air in the dome, and (vi) the amount of air in the dome and a known volume of the dome to be used to determine an amount of fresh dialysis fluid delivered into the expandable chamber.

A peritoneal dialysis (PD) system includes a housing; a dialysis fluid pump housed by the housing and including a reusable pump body that accepts PD fluid for pumping; a dialysis fluid inline heater housed by the housing and including a reusable heater body that accepts PD fluid for heating; at least one reusable PD fluid line extending from the housing; at least one disinfection connector supported by the housing and configured to accept one of the at least one reusable PD fluid line; and a control unit configured to run a disinfection sequence after a PD treatment, wherein each of the at least one reusable PD fluid line is connected to one of the at least one disinfection connectors, and wherein at least one of the dialysis fluid pump or the dialysis fluid inline heater is actuated by the control unit during the disinfection sequence.