A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.

The hemodialysis system includes a closed loop dialysate flow path which includes a dialyzer and a reservoir for storing dialysate, and a closed loop blood flow path which passes through the dialyzer in the opposite direction as the dialysate flow path. In addition, the hemodialysis system includes pumps for pumping dialysate and blood through their respective flow paths, a flow sensor for measuring the flow rate of dialysate in the dialysate flow path, and a level sensor for measuring the level of dialysate in the dialysate reservoir. A processor is connected to the flow sensor, reservoir level sensor and pumps to provide a first closed loop control system including the processor, flow sensor and a first dialysate pump, and a second closed loop control system including the processor, level sensor and a second dialysate pump which enable the processor to initiate, monitor and maintain ultrafiltration.

A method for operating a blood treatment apparatus including an extracorporeal blood circuit having a blood filter with a blood chamber and a dialysate chamber, between which a membrane is arranged. The method encompasses operating a blood pump from a first time point, at which an ultrafiltration pump is stopped, at least until a second time point, at which at least one of the following conditions is met for the first time after the first time point: a time interval after has elapsed, the blood pump has conveyed a volume after, a measurement of a fluid in the extracorporeal blood circuit exceeds or falls below a threshold.

A biological component collection system and a circuit internal pressure acquisition method are provided, which are capable of accurately measuring the circuit internal pressure. A centrifugal separation device of a blood component collection system has a first load detecting unit, an internal pressure calculation unit that calculates an internal pressure using the load detected by the first load detecting unit and internal pressure calculation data. The internal pressure calculation unit performs a calculation reflecting a change in the internal pressure calculation data depending on temperature.

A machine for extracorporeal blood treatment includes a user interface having a touch screen and a controller programmed to display on a screen (16) a display in which two distinct areas are arranged, one of which (161) exhibits a series of touch keys (17), wherein activation of any one touch key (17) causes visualization of an image in a second area (162) of the screen, wherein the images are displayed alternatively and are at least partly different one from another, wherein each touch key (17) is associated to an instruction, or to a group of instructions, each concerned with readying the machine for use, wherein each image is a pictograph of a configuration of the machine, correlated with an instruction associated to the touch key (17) selected, and wherein the operator is aided in making the machine ready for treatment.

A blood component collection cassette, kit, or system, and a flow path internal pressure detection method capable of accurately measuring a circuit internal pressure. A flow path formed in a cassette body has a first line through which blood flows when a blood component separation device is in operation, and a second line through which blood does not flow when the blood component separation device is in operation. The first line has a first pressure-receiving portion pressed by a first load detector. The second line has a second pressure-receiving portion pressed by a second load detector.

A fluid processing system for controlling fluid flow comprising a cassette comprising defined passageways within a first portion of the cassette and a filter receptacle within a second portion of the cassette, an inlet port in communication with one or more of the defined passageways and an inlet side of the filter receptacle, an outlet port in communication with an outlet side of the filter receptacle, and a filter medium disposed within the filter receptacle between the inlet port and outlet port.

Systems and methods for cleaning and disinfecting a medical therapy device that delivers any one of hemodialysis, hemodiafiltration and hemofiltration. The system has a base module that has at least one segment of a controlled compliant flow path and at least one pair of jumpered ports configured on the base module. One or more components have connections connectable to the jumpered ports of the base module to provide for fluid communication between the segment of the controlled compliant flow path in the base module and a flow path defined by the one or more components. The base module is connected to the one or more components that define a flow path configurable for carrying out in part at least one function performed during any one of hemodialysis, hemodiafiltration or hemofiltration.

The present disclosure relates to a method for determining an actual pump rate and/or for calibrating a blood pump of a blood treatment apparatus connected to an extracorporeal blood circuit. The method includes providing a blood pump of a blood treatment apparatus or establishing a signal communication to a blood pump. The blood pump comprises, or is connected to at least a first source for a fluid and at least a first line of an extracorporeal blood circuit which is connected to the first source downstream. Furthermore, the blood pump comprises, or is connected to, a reception unit for receiving fluids of the first source wherein the reception unit is in fluid communication with the first line. The reception unit is arranged on or at a first weighing device such that the weight of the reception unit or of its content is determined using the weighing device.

A photopheresis system (200) is disclosed, and that may be configured to execute one or more protocols. These protocols include: 1) protocols (400; 430; 460) for purging air out of a centrifuge bowl (210) used by the photopheresis system (200); 2) protocols (500; 510 550) for assessing the installation/operation of one or more pressure domes (330) used by the photopheresis system (200); and 3) protocols (580; 600; 660; 700; 740) for collecting buffy coat from blood processed by the photopheresis system (200).