The disclosure relates to a drug delivery device for expelling a pre-determined or pre-settable amount of a liquid medicament formulation which improves the stalling behavior and indicates the stalling state to the user. The device comprises: a medicament reservoir attached to a housing and an expelling mechanism configured for acting against the medicament reservoir in order to expel a portion of the liquid medicament formulation therefrom, the expelling mechanism comprising an arrangement of a threaded nut in a fixed axial relation to the housing and a lead screw in threaded engagement with the threaded nut, the threaded nut and the lead screw being rotatable relative to each other by a rotational input interface, a mechanical energy reservoir (for storing energy, the stored energy being releasable from the energy reservoir by a rotational interface, a drive train having upstream and downstream interfaces; and a trigger movable relative to the housing.

An injector for injecting a medicament in a patient. The injector includes a container comprising a fluid chamber containing a first volume of a medicament, and an injection conduit associated with the fluid chamber for defining a fluid pathway therefrom to inject the medicament from the fluid chamber through the injection conduit to an injection location. The injector also includes a firing mechanism associated with the fluid chamber for expelling the medicament from the fluid chamber through the injection conduit, and a volume-control mechanism operable to control a fraction of the first volume of medicament that is injected when the firing mechanism is actuated to inject the medicament.

The present invention relates to a medicament delivery device comprising a housing, an actuation mechanism (40) arranged inside said housing, the actuation mechanism comprising a plunger rod (42) arranged to act on a stopper (18) of a medicament container (16); an actuator (84) arranged slidable and connected to the plunger rod (42) for acting on the stopper (18) when said actuator (84) is operated by displacing it in a longitudinal direction of the actuation mechanism (40); an activator (104) rotatably arranged for activating said actuation mechanism and for setting a dose; said activator (104) comprising a generally tubular activator sleeve (148), said activator sleeve (148) comprises protrusions (150) arranged to interact with ledges (90) on said actuator (84) such that said activator sleeve (148) is rotated when said actuator (84) is operated. The invention is characterised in a first audio generating mechanism comprising audio generating elements (94) and said protrusions (150), which protrusions (150) are arranged to cooperate with said audio generating elements (94) for generating an audible signal after said operation for delivering a dose.

A clutch assembly with a blocking system for a medical injection device, in which a first ratchet sleeve (3) is mounted on the clutch sleeve (2), the first ratchet sleeve (3) being rotatable in two directions and cooperating with a second ratchet sleeve (4) which is mounted on the first ratchet sleeve (3), the second ratchet sleeve (4) being rotatable only in one direction, the housing (1) has an internal toothed ring (1.1), the first ratchet sleeve (3) has at least one ratchet (3.1), and the second ratchet sleeve (4) has an internal toothed ring (4.1) and at least one ratchet (4.2). The second ratchet sleeve (4) and the housing (1) have blocking means (4.3, 1.2) for preventing the arming of the device when an insufficient volume of the medicament remains in the container, by blocking the rotation of the second ratchet sleeve (4) in relation to the housing (1).

An add-on device adapted to be releasably mounted on a drug delivery device, the add-on device comprising an outer assembly with an add-on dose setting member adapted to be coupled to the outer housing of a pen housing, as well as an inner assembly engaging the pen dose setting member and being in rotational engagement with the add-on dose setting member during dose setting. The invention addresses the issue of preventing transfer of movement from the add-on dose setting member to the inner assembly during dose expelling, which in accordance with the invention is realized by rotationally de-coupling the inner and outer assembly during dose expelling.

The disclosure relates to a sensor arrangement for an injection device to determine an axial position of at least one device component of the injection device inside a housing of the injection device. The sensor arrangement includes an elongated member located inside the housing, extending in an axial direction and having at least a first section and a second section of different magnetization. The first and second sections are separated in the axial direction. The sensor arrangement also includes at least one magnetic sensor element attached to the housing to detect the axial position of at least one of the first and second sections.

A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove. The inner housing guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing.

A method of manufacturing a pen drug delivery device comprising the steps of (i) providing a drug delivery device comprising a dose indicator member adapted to move relative to a housing during dose setting and dose expelling corresponding to an axis of rotation, the indicator member having an initial position corresponding to no dose amount being set, (ii) arranging the indicator member in the initial rotational position, and (iii) providing on the housing and on the indicator member respectively a pair of zero markers having a predetermined rotational offset. By this arrangement the issue of finding the correct initial (zero) rotational position of the indicator member is addressed by providing corresponding and rotationally paired zero markings on the pen housing and the indicator member after the pen device has been assembled, this allowing the “true” initial position to be detected by image capture and subsequent image analysis.

A drive-control system for an injection device for delivering settable doses of a pharmaceutical substance contained in a cartridge, including a tubular housing body having a longitudinal axis, a proximal end and a distal end connectable to the cartridge enclosure, a helical spring contained in the housing body and a piston rod moveable towards the distal end and blocked in translation towards the proximal end. The housing body includes a control sleeve on which the spring is mounted, which rotatable around the axis, and a setting sleeve translatable along the axis. Rotation of the control sleeve in a first direction combined with compression of the spring causes the setting sleeve to be translated towards the proximal end of the housing body, and extension of the spring causes the setting sleeve to be translated towards the distal end of the housing body and the control sleeve to be rotated in a second direction and the piston rod to be pushed towards the outside of the housing body.

A drug injection device includes a last dose setting having a main drive pin, a drive wheel, a driven wheel, an abutment element fixedly coupled to, or integrally formed with, the driven wheel. The drive wheel has a rotation axis parallel to a longitudinal axis and is configured to be driven about the longitudinal axis by a knob and to be periodically driven in rotation about the rotation axis by the main drive pin, during a drug dose setting. The driven wheel has a second rotation axis parallel or coaxial to said longitudinal axis and is configured to be periodically driven about the longitudinal axis by the drive wheel. The abutment element is configured to prevent the rotation of the drive wheel about the longitudinal axis when the knob has made a predetermined number of full and/or partial rotations about the longitudinal axis correlated to the predetermined drug volume.