An injection device kit for the self-administration of an injection of solution that includes a body portion configured for engagement with a cartridge containing the solution and an injection needle where the body portion includes an injection component having an actuation mechanism for inserting the injection needle of the cartridge and for injecting the solution in the cartridge and a safety mechanism on the body portion and configured to prevent injection unless released.

The present invention relates to compositions and methods utilizing anti-TNF antibodies having a heavy chain (HC) comprising SEQ ID NO:36 and a light chain (LC) comprising SEQ ID NO:37 for use in the treatment or prevention of Type I Diabetes (T1D).

The present disclosure relates to medical delivery devices that include a barrel having an inner surface, and in at least one embodiment, the inner surface is hydrophilic. The medical delivery device may further include a stopper may having an elastomeric body, one or more fluoropolymer layers, and two or more ribs laminated to the one or more fluoropolymer layers. In some embodiments, the contact angle of the inner surface of the barrel is less than about 58?. Additionally, the stopper includes a sliding surface that is less than about 2.0 mm. The barrel provides inner surface that in combination with the fluoropolymer laminate or fluoropolymer film achieve high levels of air and liquid impermeability while also maintaining an acceptably low break loose force, low average glide force, and low glide force variation. In some embodiments, the compressibility stopper against the barrel is greater than about 7.9%.

The present invention relates to a method of assembling a drug delivery device which in the assembled state defines a distal housing component (102) that houses a piston equipped cartridge (189), and a proximal housing component (101) that houses a dose setting and expelling mechanism. The method includes the steps of arranging the cartridge (189) in the distal housing component (102), arranging a nut element (140) threadedly engaged with a piston rod (107) in the distal housing component (102), and securing the nut element (140) relative to the distal housing component (102) into a selective one of a series of predetermined relative orientations for obtaining a predetermined axial clearance or abutment between the piston rod (107) and the piston of the cartridge (189). The invention further relates to a drug delivery device assembled according to the method.

A discharger for discharging fluid includes a sleeve, a discharge section, a carriage including a receiving space disposed therein, the carriage cooperating with a proximal end of the sleeve such that the carriage is moveable relative to the sleeve, and a piercing tip having a flow channel configured to establish a flow connection for the fluid from the receiving space to an inlet of the discharge section, the piercing tip having a shell surface, the piercing tip being integrally formed with at least a portion of the sleeve or formed as a unitary separate piece linked with at least the portion of the sleeve, the shell surface of the piercing tip having a convexly curved configuration, and the sleeve surrounding a proximal end of the discharge section and having an outer diameter that is substantially the same as the inner diameter of the carriage.

A medical liquid injection device is provided. The medical liquid injection device includes a base body, a needle assembly mounted on the base body, a reservoir fluidly connected to the needle assembly and having a guide groove on an inner surface, and a driving unit configured to move a plunger disposed inside the reservoir.

A micro-metering device with a constant flow rate, including a rotary shear valve, a mounting seat, a rotation drive assembly, an injection drive assembly and a controller. The rotary shear valve includes a valve main body and a valve spool. The valve main body is provided with a main flow channel and a plurality of branch flow channels. The valve spool is rotatably arranged inside the valve main body, and is configured to communicate the main flow channel with different branch flow channels. A pressure sensor is provided inside the valve main body, and is communicated with the main flow channel. The pressure sensor is configured for detecting a pressure inside the main flow channel. Whether the switching of the liquid path is correct is determined according to the pressure in the main flow channel.

An administration instrument includes an injection button which can be pressed at an angle that is not parallel to a needle with respect to a direction in which the needle is inserted into skin. As a result, it is possible to prevent a force of pressing the injection button from being transmitted in the direction in which the needle is inserted into the skin deeper than initial insertion of the needle, thereby achieving an administration under a stable state.

A method for assembling a drive spring, especially into a drug delivery device includes rotating a component part to which the drive spring is attached in a first direction, followed by a rotation of the component part in the opposite direction and followed by attachment of a rotational stop. Further, the disclosure includes a drug delivery device for selecting and dispensing a number of user variable doses of a medicament, which device comprises a pre-charged drive spring.

The present invention relates to compositions and methods utilizing anti-TNF antibodies having a heavy chain (HC) comprising SEQ ID NO:36 and a light chain (LC) comprising SEQ ID NO:37 for use in the treatment or prevention of Type I Diabetes (T1D).