An injection device comprising a housing (1) and a cartridge holder (2, 20), the housing (1) being provided on the proximal side with a rotatable dose knob (4, 40) and an axially translatable button (5, 50). The housing (1) comprises: a dose setting sleeve (6, 60), a non-rotatable tubular driving element (7, 70) slidingly mounted in the housing (1) and engaged with the dose setting sleeve (6, 60) by a threaded connection, a non-rotatable axially sliding piston rod (15,150), a toothed gear (8, 80) comprising teeth (8.1, 80.1), a driving spring (13, 130). The dose setting sleeve (6, 60) is equipped with at least one ratchet arm (6.4, 60.4) cooperating with the toothed gear (8, 80); the piston rod (15, 150) has at least one row of ratchet teeth (15.1, 150.1) on its external surface; the driving element (7, 70) is on its distal side fixedly connected with at least one driving arm (14, 140) cooperating with the ratchet teeth (15.1, 150.1) of the piston rod (15, 150). The injection device further comprises: a non-rotatable and axially slidable button sleeve (9, 90) engaged on its proximal side with the button (5, 50), an immovable auxiliary sleeve (10, 100) located within the driving element (7, 70), wherein the button sleeve (9, 90) is detachably and slidingly engaged with the toothed gear (8, 80) and the button sleeve (9, 90) is slidingly engaged with the auxiliary sleeve (10, 100) by means of a coupling spring (12, 120).

A three-position plunger is provided including a sleeve having an opening at a distal end, a pre-load cavity proximal to and in communication with the opening, a first cavity proximal to and in communication with the pre-load cavity, a second cavity proximal to and in communication with the pre-load cavity, and at least one rib. The rib(s) is generally aligned with the first cavity. The plunger further includes an insert configured to be displaced from the pre-load cavity to the first cavity and from the first cavity to the second cavity. The insert is configured to provide support for the compression of the rib(s) when the insert is positioned in the first cavity.

Automated drug delivery systems and related methods are disclosed herein. In some embodiments, these systems can reduce or eliminate infusion inconsistencies. An exemplary system can include a syringe actuator which can be controlled via electrical, mechanical, pneumatic, and/or hydraulic means to precisely infuse and/or withdraw material from a patient.

A drug delivery device is provided comprising a housing having an exterior surface, drug ex-pelling means comprising an indicator member arranged to move corresponding to an action performed on or by the drug delivery device, and a carrier foil on which is formed or mounted an energy source, electronically controlled communication means, and a processor adapted to (i) receive input from the drug delivery device indicative of indicator member movement and (ii) control the communication means. The flexible carrier foil is mounted on the exterior of the housing, and the flexible carrier foil is covered at least in part by a sealing foil covering directly or indirectly the thereon formed or mounted components, whereby a sealed interior space for the components formed or mounted on the flexible carrier foil is formed between the housing exterior surface and the sealing foil.

In an embodiment, a resettable injection training device and a method embodiment for resetting the device is provided herein. The device may include a housing having a proximal end and a distal end, the housing defining a cavity there within. A plunger may be slidable relative to the housing between the proximal end and the distal end. A releasably locking shield having a proximal end and a distal end, and being slidably engaged with the housing is also provided. The shield may be slidable between a retracted, pre-use position an extended, locked, post-use position. The device may further include a flat biasing member for locking the shield in the extended position, and a compressing component slidable relative to the housing, wherein pressure on the flat biasing member from the compressing component deforms the flat biasing member, and unlocks the shield, and wherein a release of pressure by the compressing component on the flat biasing member locks the shield in an extended, post-use position.

Drug delivery systems and methods of use thereof for recording administration of a drug dose to a subject are provided. Aspects of the invention include a syringe stopper rod comprising a sensor component that is configured to detect a delivery signature, and to transmit a report comprising a drug dose completion signal to a data management component, e.g., a mobile computing device.

A liquid dispensing system for oral administration comprises a dispenser (16,18,20) and cartridges (14) from which medicine is dispensed. Each cartridge (14) includes a hollow shell (22,24) with a septum (26) at one end, a piston (28) at the other end, and the medicine in a cavity (23) between the septum and the piston. The dispenser includes receiver (20) in which a cartridge (14) is received, a plunger (18) that can slide relative to the receiver and that has a plunging head (52) that can drive the piston (28), and a barrel (16) in which the cartridge (14), receiver (20) and plunger (18) can be received, at least partly. Once a cartridge (14) has been inserted into the receiver (20), the receiver and cartridge are inserted into the barrel (16) and a piercing head (44) ruptures the septum (26). The plunger (18) is pushed to drive the piston (28) and the medicine is dispensed by the piston, through a discharge passage (42) of the barrel (16). The septum (26) can hinge on a hinge formation (86) to act as a one-way valve to prevent unintentional flow of liquid from the cartridge.

An autoinjector may include a disposable portion and a reusable portion. The disposable portion may include a syringe and a syringe coupling. The syringe coupling may be coupled to the syringe, and may comprise a guide track. The reusable portion may include a device housing, a device actuator configured to initiate an injection of the autoinjector, and a motor coupled to the device actuator. The reusable portion may additionally include a motor foot coupled to an output of the motor, wherein the motor foot may be configured to translate in an axial direction. The reusable portion may also include a drive coupling disposed within the device housing. The drive coupling may include an angled surface configured to receive the motor foot and a protrusion configured to engage with the guide track of the syringe coupling to lock the drive coupling to the syringe coupling.

An injection device includes a drive mechanism, and the drive mechanism in turn includes a drive rod being axially moveable, a plunger rod being axially moveable, and a gear assembly. The gear assembly is arranged such that an axial movement of the drive rod generates an axial movement of the plunger rod. This allows for a force transmission between the drive rod and the plunger rod, facilitating the expelling of viscous substances from the injection device.

A three-position plunger is provided including a sleeve having an opening at a distal end, a pre-load cavity proximal to and in communication with the opening, a first cavity proximal to and in communication with the pre-load cavity, a second cavity proximal to and in communication with the pre-load cavity, and at least one rib. The rib(s) is generally aligned with the first cavity. The plunger further includes an insert configured to be displaced from the pre-load cavity to the first cavity and from the first cavity to the second cavity. The insert is configured to provide support for the compression of the rib(s) when the insert is positioned in the first cavity.