A drug delivery device (100, 200) for delivering a fixed dose, wherein the drug delivery device comprises: a housing assembly, a drug reservoir with a piston and a drive mechanism. The drive mechanism comprises a piston rod (109, 209) for advancing the piston to expel a drug, and a drive tube (180, 280), wherein the drive mechanism is adapted to deliver the predefined fixed dose in response to activation. The drug delivery device further comprises an activation mechanism for activating the drive mechanism, in response to moving the drive tube in an axial direction. The housing assembly comprises a guide structure for guiding the drive tube during activation and delivery of a dose, wherein the guide structure comprises an axial portion (156, 256) providing a sliding surface for guiding the drive tube during activation, and for providing a rotational stop defining an end of dose, and a helical portion (157, 257) providing a sliding surface adapted for guiding the drive tube (180, 280) during dosing. The drive tube (180, 280) comprises a guide structure comprising an axial portion (182, 282) adapted for slidably engaging the axial portion of the housing assembly for activation, and a helical portion (189, 289) for slidably engaging the helical portion of the housing assembly during dosing during dosing.

A dosage sensing module for or in a pen drug delivery device and comprising a power source unit, a processor unit and a dosage sensor unit with a first sensor part adapted to be fixed to a part not rotating during dose expelling and comprising a flexible printed circuit board sheet on which a pattern of individual electrical conductive sensor areas are arranged. The sensor unit further comprises a second sensor part adapted to be fixed to the piston rod to follow the rotation thereof during dose expelling. The second sensor part comprises individual structures that together with the conductive sensor areas are adapted to, upon relative rotational movement between the first and second sensor part, provide electrical signals to a processor unit indicative of the relative rotational position between the first and second sensor part.

A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.

A dosing mechanism for an injection device includes a dose-setting element with a first element coupled thereto, which, during dose setting, is rotatable relative to a second element about a main rotation axis in a first direction and, during dose discharge, is fixed in rotation relative to the second element. The first and the second elements are coupled via a sleeve-shaped stop element, which forms a stop abutment. The dosing mechanism includes a stop, and the stop abutment, during the rotation of the first element in the first direction, executes a movement to a stop position where the stop abutment strikes the stop and prevents rotation of the first element relative to the second element in the first direction of rotation. The sleeve-shaped stop element is rotatable about a secondary rotation axis, which is offset parallel to or offset at an angle to the main rotation axis.

The present invention provides a piston rod displacement mechanism for a pen injection device, comprising: a tubular housing (2) extending along a reference axis and comprising an interior housing surface (3) with a first engagement structure (4), a nut member (5) fixed within the tubular housing (2), a piston rod (15) comprising a first non-self-locking thread (18) having a first thread direction and a first thread pitch and being engaged with the nut member (5), and a second non-self-locking thread (17) superposed on the first non-self-locking thread (18), the second non-self-locking thread (17) having a second thread direction and a second thread pitch, and a dose dial sleeve (20) operable to advance the piston rod (15) in the nut member (5), the dose dial sleeve (20) comprising an exterior sleeve surface (21) with a second engagement structure (24) being in sliding engagement with the first engagement structure (4), and an interior sleeve surface (23) with a third engagement structure (29) being engaged with the second non-self-locking thread (17). One of the first engagement structure (4) and the second engagement structure (24) comprises a closed-circuit track configuration and the other of the first engagement structure and the second engagement structure comprises a track follower, and the closed-circuit track configuration comprises a helical track portion (24h) having a helical track direction equaling the second thread direction and a helical track pitch equaling the second thread pitch, and an axial track portion (24a) extending between a distal track end (24d) and a proximal track end (24p) and being connected to the helical track portion (24h) at the distal track end (24d).

A method of assembling a drug delivery device, comprising the steps of: inserting a piston rod in a nut portion of a cartridge assembly and rotating the piston rod until the piston rod distal end engages the cartridge piston, mounting a drive member on the piston rod in a rota-tional position being closest to a pre-determined rotational position, and rotating the drive member to the pre-determined rotational position.

The present invention provides a sensor module (50) adapted to be arranged in a cartridge based drug delivery device between a rotatable piston rod and a cartridge piston. The sensor module (50) comprises a first sensor structure (52, 152, 252, 352) adapted to be at least substantially rotationally locked with respect to the cartridge piston and comprising a transversal sensor surface (52.2, 152.2, 252.2, 352.2), and a second sensor structure (53, 153, 253, 353) adapted to be rotationally locked with respect to the piston rod and comprising one or more flexibly supported and axially deflectable contact members (53.1, 53.2, 153.2, 253.2, 353.1, 353.2), which are positioned distally of the transversal sensor surface (52.2, 152.2, 252.2, 352.2) and are adapted to apply a proximally directed force thereto. The first sensor structure (52, 152, 252, 352) and the second sensor structure (53, 153, 253, 353) are adapted to undergo relative rotational motion, whereby the one or more contact members (53.1, 53.2, 153.2, 253.2, 353.1, 353.2) sweep the transversal sensor surface (52.2, 152.2, 252.2, 352.2). A processor (52.5, 152.5, 252.5) determines a relative angular displacement between the first sensor structure (52, 152, 252, 352) and the second sensor structure (53, 153, 253, 353) from signals generated as the one or more contact members (53.1, 53.2, 153.2, 253.2, 353.1, 353.2) sweep the transversal sensor surface (52.2, 152.2, 252.2, 352.2).

A connector for connecting a medical injection device having a distal tip, a needle extending from the distal tip and a sleeve extending around the tip comprising an inner threaded portion, to a container including a collar closed by a pierceable septum, including: a proximal part configured to sealingly engage the tip of the injection device so as to enclose at least a part of the needle; a distal part configured to be connected to the container, including a skirt configured to extend around the needle when the connector is connected to the injection device; and a needle shield configured to be mounted on the needle, so as to sealingly enclose at least the tip of the needle, the needle shield being configured to be pierced by the needle inserted via the opening for sealingly enclosing said needle.

An ambulatory infusion device including a pump drive unit, a valve drive unit and a control unit. The pump drive unit includes a pump actuator and a pump driver coupled to a piston of a metering pump unit. The valve drive unit includes a valve actuator and a valve driver coupled to a valve unit for transmitting a valve switching force or torque. The control unit controls a repeated execution of: (a) placing the valve unit in a filling state; (b) displacing the piston in a retraction direction; (c) displacing the piston in an advancing direction by a backlash compensation distance; (d) switching the valve unit from the filling state into a draining state; and (e) further displacing the piston in the advancing direction in a number of incremental steps over an extended time period.

A medicament delivery device includes a housing having a longitudinal axis, a container holder, an axially movable plunger adapted to be displaced along the longitudinal axis into the container holder, and an energy accumulating member arranged inside the housing and adapted for displacing the plunger along the longitudinal axis. The plunger includes an outer plunger rod and an inner plunger rod arranged at least partially inside the outer plunger rod, the inner plunger rod being threadedly engaged with the outer plunger rod and manually rotatable to displace the inner plunger rod along the longitudinal axis into the container holder.