There is provided inter alia an aqueous liquid pharmaceutical formulation comprising (i) an insulin compound at a concentration of 500-1000 U/ml, (ii) ionic zinc, (iii) a zinc binding species at a concentration of 1 mM or more selected from species having a logK with respect to zinc ion binding in the range 4.5-12.3 at 25? C., and (iv) a non-ionic surfactant; and wherein the formulation is substantially free of EDTA and any other zinc binding species having a logK with respect to zinc ion binding of more than 12.3 at 25? C.

A method includes moving an actuation lock of a medical injector from a first position to a second position. The actuation lock has an extended portion disposed between a shoulder of a housing and the base when the actuation lock is in the first position. The extended portion is spaced apart from the base when the actuation lock is in the second position. A distal end portion of a base, which is movably coupled to an end portion of the housing, is placed into contact with a body. The base is actuated after the placing to release an energy from an energy storage member within the housing to produce a force to move a needle from a first needle position to a second needle position. At least a portion of the needle extends through the base when the needle is in the second needle position.

The present invention relates to a medicament delivery device comprising a housing, which housing is arranged to accommodate a medicament container, which medicament container comprises a medicament delivery member; a power unit interactively connected to the housing comprises a force element and a plunger rod which is arranged to, upon activation, move linearly in the proximal direction and act on said medicament container for expelling a dose of medicament through said medicament delivery member; and a holding member connected to said power unit and to said container holder. The invention is characterized in that the plunger rod comprises at least one first guide-and-stop element configured to interact with at least one second guide-and-stop element on said a holding member for limiting the linear distance the plunger rod is capable of moving during expelling of medicament and which distance corresponds to a dose volume.

A syringe includes a barrel with an internal surface defining an internal bore therein, a plunger disposed within the internal bore of the barrel, and a dose divider disposed on the plunger. The dose divider includes a first end, a first abutment surface, and a second abutment surface. The first abutment surface is spaced apart from the first end in the axial direction by a first axial distance, and the second abutment surface is spaced apart from the first end in the axial direction by a second axial distance. The second abutment surface is spaced apart from the longitudinal axis of the plunger by a first radial distance, and the first radial distance is greater than a radial dimension from a longitudinal axis of the barrel to the internal surface of the barrel near a proximal end of the barrel.

A limiter for a dispensing device is provided. The limiter includes a body (20) arranged to mount with at least a portion of a dispensing device (300), and a stop extending from the body. The stop (40) is configured to permit movement a plunger of the dispensing device a predetermined distance in a dispensing direction correlated to a desired volume of medium to be delivered from the dispensing device. The stop is configured to prevent further movement of the plunger in the dispensing direction, thereby limiting the amount of medium delivered from the dispensing device. The dispensing device may be a syringe.

A device for administering a fluid medicament by injection comprises a dosing portion (1) with a collapsible reservoir (10). The reservoir (10) has a maximum volume in an extended state and a minimum volume in a collapsed state. Prior to injection, the reservoir (10) is in the extended state and contains a liquid to be administered, and the reservoir (10) is biased towards the collapsed state. The device further comprises a needle (2), wherein a lumen (20) of the needle (2) is in fluid communication with the reservoir (10). The device further comprises a shield portion (3) with a plug (30). Prior to injection, the shield portion (3) is in a deployed position where the plug (30) blocks the lumen (20) of the needle (2). The shield portion (3) is adapted to move in response to an actuation force from the deployed position to a retracted position where the lumen (20) of the needle (2) is open, thereby causing the reservoir (10) to shift to the collapsed state to expel the liquid through the needle.

An injection assembly includes a housing with a barrel positioned within the housing. The barrel includes an axis extending from a proximal end to a distal end thereof and a chamber for storing medicine. An elongate anti-rotation shaft is rotationally fixed to the housing and has a non-circular cross-section. The injection assembly includes an inner screw having an inner screw opening to complementarily receive the anti-rotation shaft to prevent rotation of the inner screw with respect to the anti-rotation shaft but allow respective linear translation along the axis. An outer screw is positioned within, and rotatable with respect to, the housing and has an outer screw opening to threadably receive the inner screw, wherein rotation of the outer screw translates the inner screw along the axis and along the anti-rotation shaft. A plunger is coupled to the distal end of the inner screw and is moveable with respect to the chamber to push the medicine out of the chamber when the outer screw is rotated.

The present invention relates to a drive mechanism (10; 177) for a medicament delivery device, which drive mechanism (10; 177) comprises an elongated plunger rod (12; 176), wherein the plunger rod comprises a number of discrete segments (14; 178), interlocking elements (18, 20, 32, 34, 60, 62; 182, 184, 196, 198, 212, 214) arranged between adjacent segments operably arranged to releasably locking adjacent segments, drive force elements (30, 50 71; 194, 210, 230) operably arranged to act between adjacent segments, and release elements (46, 68; 208, 228) operably arranged to act on said interlocking elements (18, 20, 32, 34, 60, 62; 182, 184, 196, 198, 212, 214) such that said segments (14; 178) are released in sequence.

The present invention relates to a medicament delivery device. The medicament delivery device comprises a housing, a needle, a medicament delivery mechanism and an actuator. The needle is moveable from a retracted position, wherein the needle is fully received in the housing, to an extended position, wherein the needle protrudes out of the housing. The medicament delivery mechanism comprises a reservoir and dispensing member each disposed in the housing, first and second biasing members, and first and second locking members. The actuator is moveable relative to the housing from an initial position to an intermediate position such that the actuator exerts a force on the first locking member to urge the first locking member from a locked state to an unlocked state wherein the first biasing member moves the needle from the retracted position to the extended position. The actuator is moveable relative to the housing from the intermediate position to a second position such that the actuator exerts a force on the second locking member to urge the second locking member from a locked state to an unlocked state wherein the second biasing member moves the dispensing member within the housing to dispense medicament from the reservoir when the reservoir contains medicament.

A pneumatic retractable syringe has a plunger having an interior retraction lumen. The plunger and syringe barrel have cooperating locking elements so that the plunger is locked after use within the syringe barrel. After injection of medicament is completed, the needle is retracted into the lumen by compressed gas that is released from a gas cell within the syringe when the gas cell is ruptured just before the plunger reaches the end of its downstream path of travel.