The application describes lock mechanisms for medicament delivery devices. The lock mechanisms extend from a proximal end to a distal end in an axial direction relative to a longitudinal axis, the lock mechanisms can have a housing, a medicament delivery member guard and a cap. The lock mechanisms can also include a protrusion extending in a radial direction relative to the longitudinal axis and a recess or cut-out. Various related medicament delivery devices, medicament delivery device components, sub-assemblies and methods are also described.

The application describes a medicament delivery member guard lock assembly for a medicament delivery device, the medicament delivery member guard lock assembly includes a housing having a recess or a slit; a medicament delivery member guard slidably arranged in the housing, the medicament delivery member guard extending from a proximal end to a distal end; a lock activation sleeve slidably arranged in the housing at the distal end of the medicament delivery member guard; and a medicament delivery member guard lock arranged in the housing adjacent to the lock activation sleeve, wherein the medicament delivery member guard lock has a flexible arm pivotally attached to a base, wherein the flexible arm has a proximal part, a distal part and is attached to the base between the proximal part and the distal part, and wherein the proximal part of the flexible arm is arranged adjacent to the recess or slit in the housing.

The present disclosure concerns an autoinjector needle-housing assembly extending along an axis in a longitudinal direction from a proximal end to a distal end, the autoinjector needle-housing assembly has a housing having a proximal part and a distal part attached to the proximal part, a needle attached to the proximal part of the housing, and a sterility barrier attached to the distal part of the housing, wherein the housing and the sterility barrier form a first sealed cavity, wherein a distal end of the needle is in the first sealed cavity, wherein the autoinjector needle-housing assembly has a recess formed by the distal end of the autoinjector needle-housing assembly, wherein the recess is shaped to receive a cartridge and to form a second sealed cavity between the autoinjector needle-housing assembly and said cartridge. Corresponding methods are also described.

The present invention provides pharmaceutical formulations comprising an antibody that specifically binds to human interleukin-33 (hlL-33). The formulations may contain, in addition to an anti-IL-33 antibody, a buffer, at least one amino acid, at least one sugar, or at least one non-ionic surfactant. The pharmaceutical formulations of the present invention exhibit a substantial degree of antibody stability after storage for several months and after being subjected to thermal and other physical stresses.

An injection device (10) includes a lower housing (18), a sleeve (32) supported by the lower housing, and a syringe spring (34) received within the sleeve. The spring supports a syringe (12). A needle guard (26) is proximally slidable relative to the lower housing from a first position, concealing the syringe needle (12b), to a second position. A needle guard spring (27) biases the needle guard distally relative to the lower housing. An upper housing (16) is distally slidable relative to the lower housing from a pre-use position to a dispensed position. Movement of the needle guard from the first position to the second position extends the distal tip of the needle distally beyond the needle guard by a first distance. Subsequent distal movement of the upper housing relative to the lower housing from the pre-use position toward the dispensed position advances the distal tip of the needle distally further beyond the needle guard by a second distance.

A needle-based device includes a barrel as a body thereof and a needle. A portion of the needle is received within the barrel and glued thereinto to cause the needle to protrude from the barrel. The needle-based device also includes a needle shield to protect an entire length of the needle protruding from the barrel based on completely encompassing the entire protruding length of the needle in a first state of disuse of the needle-based device. The barrel includes wings on lateral sides of an outer wall thereof. The wings extend perpendicular to a length of the barrel to couple the needle shield to the barrel in the first state of disuse of the needle-based device.

A method includes protecting an entire length of a needle of a needle-based device protruding from a needle mount or a body of the needle-based device in a first state of disuse thereof based on providing a needle shield encompassing the entire protruding length of the needle, and encompassing the needle shield completely in the first state of disuse with an external cap. The method also includes providing a guide element protruding inward from an end of the external cap farthest away from the needle mount or the body of the needle-based device, internal to the external cap parallel to a length of the external cap and through the needle shield such that, in the state of disuse, the guide element at least partially envelops the needle therewithin to prevent significant lateral movement of the needle and prevents the end of the external cap from touching the needle.

A drug delivery device comprises an outer surface and a region for receiving a medicament container. The region has an inner surface to contact and support a medicament container received therein. The device also includes a thermal bridge extending between the inner surface and the outer surface to conduct heat between the inner surface and the outer surface. The thermal bridge has a thermal conductivity equal to or greater than 10W/mk.

A medicament delivery device is presented having a drive configured to act on a medicament container for expelling a medicament; a holder configured to hold said drive in a pre-tensioned state; an activator configured to interact with said holder for releasing said drive from the pre-tensioned state; wherein the device further includes a feedback mechanism configured to interact both with said holder and with said drive for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.

A medicament delivery device is presented having a drive configured to act on a medicament container for expelling a medicament; a holder configured to hold said drive in a pre-tensioned state; an activator configured to interact with said holder for releasing said drive from the pre-tensioned state; wherein the device further includes a feedback mechanism configured to interact both with said holder and with said drive for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.