Photobiomedulation therapy (PBMT) can be applied to the eye to treat optical neuritis, a sign of multiple sclerosis (MS). The light of PBMT can be directed into the eye, regardless of the position of the eye, by a device that includes an array of light delivery devices and a heat sink lens. The device can be placed proximal to the eye to direct the light into the eye. The light can have one or more wavelengths from 400-1100 nm and can be applied in at least one of a pulsed operating mode, a continuous operating mode, and a super-pulsed operating mode through the light source device to the skeletal muscle. The light signal is applied for a time sufficient to stimulate a phototherapeutic response in the retina and/or the optic nerve. PBMT applied in this manner provides a noninvasive, safe and effective treatment for optic neuritis.

Gamma brain stimulation for preventing or treating Alzheimer's disease or sleeping disorders using light or sound is known. A strobing 40 Hz light source has been shown to cause positive effects due to the stimulation. It is an advantage to know the actual dosage of light that enters the person's eyes in order to understand the relationship between dosage and effectiveness. A camera is used to detect the subject's gaze angle, distance, pupil diameter and any other factors that affect the light power that enters the eye. A target dosage is first determined by a medical worker, such as to determine the effects of the exact same dosage on a group persons, such as Alzheimer's patients. With deviations of gaze angle, distance, and pupil size from the ideal, the effective dosage is decreased. The disclosed system adjusts the actual dosage, such as session duration, based on such factors so that the final dosage received by the person is consistent and meets the target dosage.

Systems and methods for adjusting a user's circadian rhythm are provided. In some embodiments, a system may be configured to obtain information relating to the user's present circadian rhythm and information relating to one or more anticipated times of sleep and/or wakefulness. The system may generate a model for estimating the user's circadian rhythm. The system may also generate a model for estimating the user's homeostatic sleep drive. Based on one or both models, the system may generate instructions for activating the light source to adjust the user's circadian rhythm.

A method for application of light to one or more eyes (300) of a user is disclosed. The method comprises identification (110) of location of an optic disk (330) on a retina (320) in the one or more eyes (300) and selectively applying (115) the light onto the optic disc (330) to stimulate the optic disk (330).

A device for obtaining retinal ERG signals from a target area of the retina, the device comprising means for obtaining an electrical response signal from the target area and at least one light source configured to provide at least a stimulus beam configured to illuminate the target area for inducing an ERG signal and a light adapting background beam configured to illuminate the retina at least in an area outside of the target area, for light adapting the area outside of the target area and suppressing ERG signaling therefrom.

A neuromodulator may output stimuli that causes a user to fall asleep faster than the user would in the absence of the stimuli. Alternatively, the stimuli may modify a sleep state or behavior associated with a sleep state, or may cause or hinder a transition from a waking state to a sleep state or from a sleep state to another sleep state. The neuromodulator may take electroencephalography measurements. Based on these measurements, the neuromodulator may detect, in real time, instantaneous amplitude and instantaneous phase of an endogenous brain signal. The neuromodulator may output stimulation that is, or that causes sensations which are, phase-locked with the endogenous brain signal. In the course of calculating instantaneous phase and amplitude, the neuromodulator may perform an endpoint-corrected Hilbert transform. The stimuli may comprise auditory, visual, electrical, magnetic, vibrotactile or haptic stimuli.

To prove an optical probe that can illuminate an entire desired region at one time, even in a narrow space. An optical probe including: a linear light guide to guide light from a light source device; a planar emitter to be connected to a tip portion of the linear light guide, to emit the light; a reflective surface provided in a part of the planar emitter, to reflect the light having entered the planar emitter; and an emitting surface provided so as to face the reflective surface, to allow the light reflected by the reflective surface to be emitted from a region of the reflective surface.

In various implementations, a device for stimulating the lacrimal gland and optionally the meibomian gland of an eye of a user by emitting light on the retina may include a control unit and an optical system connected to the control unit and arranged in the viewing direction of the user. The optical system may include at least one light source and may be configured for providing light stimulation pulses to an eye of the user by the at least one light source. Implementations of the device may also include a power supply unit for supplying power to the control unit and/or optical system. The light stimulation pulses activate the pupillary light reflex and one or more reflexes selected from blink reflex, corneal reflex, menace reflex, and lacrimal reflex. When the device is in operation mode a light intensity gradient between the light pulses emitted by the at least one light source and the light around the eye may be maintained at 2 or more lumens. The light stimulation pulses may induce blinking of the eye of the user.

A computer implemented method for controlling a device adapted for projecting an image on at least a part of an eye of a wearer of said device, the method comprising the steps of providing the direction gaze of an eye of the wearer, providing an initial image to be projected, determining at least a filter depending from the provided gaze direction, filtering the initial image using the determined filter, and sending a command to the device for projecting the filtered image in the eye.

A wearer adjustable apparatus is configured for a wearer to view an object and adjust stimuli projected into the eye by adjusting the location of the projection optics, for example with movement of the projection optics relative to one or more components of a support such as an eyeglass frame. In some embodiments, the projection system comprises an adjustable retainer for the wearer to adjust first active projection elements coupled to a first support in front of a first eye in relation to second projection optics coupled to a second support in front of a second eye of the wearer. In some embodiments, the apparatus comprises oculars comprising the projection optics and corrective lenses configured for the wearer to adjust positions of the lenses and projection optics in front of the wearer's eyes in order to project therapeutic spots onto a desired location relative to the wearer's retinas.