A system that provides neuroprotection or neuroregeneration to biological tissue includes a pulsed energy having energy parameters including a wavelength or frequency, a duty cycle and a pulse train duration. A delivery device applies the pulsed energy to neural elements of the target tissue having a chronic progressive disease or at risk of having a chronic progressive disease. The delivery device applies the pulsed energy for a predetermined total pulse train duration such that the target tissue temperature is raised sufficiently to provide neuroprotection or neuroregeneration to the neural elements of the target tissue, while maintaining the average temperature rise of the target tissue at or below a predetermined level so as not to permanently damage the target tissue.

An electronic device is disclosed comprising: a frame configured to be worn on a head of a user; a first light emitter mounted on the frame and configured to illuminate a first eye of the user, wherein an intensity and a spectrum of the first light emitter is adjustable; a second light emitter mounted on the frame and configured to illuminate a second eye of the user, wherein an intensity and a spectrum of the second light emitter is adjustable; a clock; a memory configured to store a target light profile comprising time-resolved data on an amount of light to be accumulated over time by the first and/or second eye of the user, wherein the time-resolved data comprises information about spectrum and intensity; and a controller configured to control the intensity and spectrum of the first and second light emitter based on the time and the target light profile.

A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.

An illumination system adapted for an eyewear that includes a light source configured to emit a first light including a power spectrum having full width at half maximum of less than 100 nm in a first range of wavelengths and a second light including a power spectrum having full width at half maximum of less than 100 nm in a second range of wavelengths, the power spectrum of the first light and the power spectrum of the second light differ from each other, and the light source is further configured to emit pulses of light with a pre-determined time function. The pre-determined time function comprises a plurality of packets, each packet of the plurality of packets being followed by a packet interval, and each packet including a pulse alternation between a pulse of the first light and a pulse of the second light.

A device for therapeutic treatment of the retina includes a holding and positioning device for holding an optical lens element in a defined position and orientation in front of the eye of a patient, the lens element having a irradiation-transmitting concave surface for resting on the closed eyelid, and the irradiation source cooperating with the optical lens element to deliver the therapeutically effective irradiation to the retina via the optical lens element.

One embodiment is directed to a system comprising a head-mounted member removably coupleable to the user's head; one or more electromagnetic radiation emitters coupled to the head-mounted member and configured to emit light with at least two different wavelengths toward at least one of the eyes of the user; one or more electromagnetic radiation detectors coupled to the head-mounted member and configured to receive light reflected after encountering at least one blood vessel of the eye; and a controller operatively coupled to the one or more electromagnetic radiation emitters and detectors and configured to cause the one or more electromagnetic radiation emitters to emit pulses of light while also causing the one or more electromagnetic radiation detectors to detect levels of light absorption related to the emitted pulses of light, and to produce an output that is proportional to an oxygen saturation level in the blood vessel.

A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

A device for irradiation of the eye of a living subject with light such as UV light includes a structure (20) adapted to overlie the outer surface of the eye, the structure having an axis (28, 128) extending in a downward direction (D) towards the eye when the structure overlies the eye. A light scattering element (70, 158, 141) within the structure includes a peripheral portion remote from the axis and a central portion adjacent the axis. A plurality of transmission optical fibers (42, 157) in optical communication with the peripheral portion of the light scattering element at a plurality of locations spaced around the axis.

A light emission apparatus emits light that activates a human body. The light emission apparatus includes a light-emitting module that emits light from a light emission region. The light emission region includes a first light emission region that emits light having a first luminance and a second light emission region that emits light having a second luminance greater than the first luminance. The second light emission region is a different region than the first light emission region. The first light emission region is located in a central region of the light emission region. The second light emission region is peripheral to the first light emission region. The light having the first luminance emitted from the first light emission region has a predetermined wavelength that activates the human body.

A cartridge, medical apparatus and method are disclosed. The cartridge and a holding element are for operable connection with each other to form a phototherapy apparatus. The cartridge includes a radiation source for emitting radiation towards an area to be treated of a user; a mount element for positioning the radiation source in a predetermined position relative to the area to be treated; wherein the mount element comprises a locating portion configured for locating the cartridge at a predetermined position with respect to a body portion of the user.