A method for locating a material having thermoplastic properties in pores of bone tissue includes providing a pin having the material having thermoplastic properties and a core, wherein the material having thermoplastic properties is arranged on the circumferential surface of the core constituting an outer region of the pin. An opening is provided in the bone tissue, and the pin is positioned at least partly in the opening. The outer region of the pin is then impinged with mechanical vibration energy for a time sufficient for liquefying at least part of the material having thermoplastic properties, and, in a liquefied state, pressing it into the pores of the bone tissue surrounding the opening. The vibration energy is stopped for a time sufficient for re-solidification of the liquefied material, and then the core is removed.

The present disclosure provides a system of gender specific pharmaceuticals. The system includes a first package of a pharmaceutical for use by a male and a second package of a pharmaceutical for use by a female. The first package includes at least one male dosage having a first dosage amount, an insert positioned in the first package, the insert including a recommended male dosage and a recommended female dosage that is different than the male dosage, and a male label coupled to the first package, the label including a male gender specifier. The female package includes at least one female dosage having a second dosage amount that is smaller than the first dosage amount, an insert positioned in the first package, the insert including a recommended male dosage and a recommended female dosage that is different than the male dosage, and a female label coupled to the second package, the female label including a female gender specifier, wherein the female gender specifier is different than the male gender specifier.

An implant includes a fixed bearing, a floating bearing, and a coupling member. The fixed bearing defines a generally first spherical articulating surface and a stop. The floating bearing includes a second spherical articulating surface and a planar articulating bearing surface. The coupling member defines a bearing surface that translates relative to the planar articulating bearing surface.

The disclosure includes a method for providing prosthetic implants for a total knee replacement procedure. This method includes receiving data representative of a knee joint of a patient and determining anatomical parameters from the received data. The method also includes creating a graphical model of the knee joint based on the determined anatomical parameters, and providing a femoral component of a knee joint implant based on at least one of the determined anatomical parameters and the graphical femoral portion. This method also includes providing at least one cutting instrument configured to facilitate removing a portion of the femur of the patient based on at least one of determined anatomical parameters and the graphical model.

A method of manufacturing a resorbable balloon designed to contain bone cement for vertebroplasty or kyphoplasty applications is described. The resorbable balloon can be inserted into a vertebral body following vertebral cavitation and filled with bone cement. The balloon remains in place in the vertebral body and resorbs over time. Methods and apparatus are also described for delivering therapeutic agents using collapsible, resorbable balloons. The balloons may be nested and filled with various therapeutic agents that are released over time at rates dependent upon structures and degradation rates of the balloons. Furthermore, the function of the hollow devices can encompass both encapsulation and therapeutic substance delivery roles simultaneously.

The invention encompasses devices and methods for treating one or more damaged, diseased, or traumatized intervertebral discs to reduce or eliminate associated back pain. Specifically, the invention encompasses intervertebral nucleus and annulus implants that are resistant to migration in and/or expulsion from an intervertebral disc space. The invention further encompasses kits including the implantable devices of the invention and associated delivery tools to treat annular and nuclear tissue.

An adjustable spinal fusion intervertebral implant including upper and lower body portions each having proximal and distal surfaces at proximal and distal ends thereof. The implant can include a proximal wedge member disposed at the proximal ends of the respective ones of the upper and lower body portions, and a distal wedge member disposed at the distal ends of the respective ones of the upper and lower body portions. First and second linkages can connect the upper and lower body portions. Rotation of an actuator shaft can cause the distal and proximal wedge members to be drawn together such that longitudinal movement of the distal wedge member against the distal surfaces and the longitudinal movement of the proximal wedge member against the proximal surfaces causes separation of the upper and lower body portions.

A spinal implant comprises a first member defining a longitudinal axis and including a wall that defines an axial cavity and at least one lateral opening configured for disposal of an instrument. A second member is configured for disposal with the axial cavity and includes a wall having an axial surface disposed along a thickness thereof. The axial surface defines at least a portion of an axial opening and includes a plurality of gear teeth disposed therealong. The instrument is engageable with the teeth to axially translate the second member relative to the first member. Systems and methods of use are disclosed.

An implant includes a fixed bearing, a floating bearing, and a coupling member. The fixed bearing defines a generally first spherical articulating surface and a stop. The floating bearing includes a second spherical articulating surface and a planar articulating bearing surface. The coupling member defines a bearing surface that translates relative to the planar articulating bearing surface.

A spinal implant body, including a body volume having an inferior portion, a superior portion, and a central portion disposed between the inferior and superior portions. The body further includes a first bioactive polymer portion distributed throughout body volume, a second bioactive ceramic portion distributed throughout the body volume, and a third interconnected pore network portion distributed throughout the body volume. The central portion is less porous than the inferior and superior portions and the pores in the inferior portion are on average larger than the pores in the central portion.