An implant assembly including an expandable vertebral body replacement implant. Two outer cores disposed on opposing ends of an inner are configured to move away from each other when the inner core is actuated. The implant assembly may include removable endplate configured to engage vertebral bodies as interbody spacer or through a corpectomy. The implant may include a locking mechanism to prevent collapse or movement the implant assembly after implantation. The locking mechanism may be automatically engage after removal of an inserter instrument from the implant assembly.

Computer implemented methods of producing a bone graft are provided. These methods include obtaining a 3-D image of an intended bone graft site; generating a 3-D digital model of the bone graft based on the 3-D image of the intended bone graft site, the 3-D digital model of the bone graft being configured to fit within a 3-D digital model of the intended bone graft site; storing the 3-D digital model on a database coupled to a processor, the processor having instructions for retrieving the stored 3-D digital model of the bone graft and for combining a carrier material with, in or on a bone material based on the stored 3-D digital model and for instructing a 3-D printer to produce the bone graft. A layered 3-D printed bone graft prepared by the computer implemented method is also provided.

A bone graft delivery system and method for using same to deliver graft material into a surgical site. The method includes the steps of providing a hollow tube configured to receive the graft material, releasably attaching an implant to a distal end of the hollow tube so as to communicate with at least one opening in the distal end of the hollow tube, the implant being configured to receive the graft material delivered through the hollow tube; placing the implant within the surgical site; advancing the graft material through the hollow tube; conveying graft material through the hollow tube into an interior of the implant, whereby the implant is at least substantially filled with the graft material; and discharging the graft material through at least one opening in the implant into the surgical site, whereby the surgical site is at least substantially filled with the graft material.

A composition and methods of making or use thereof include a plurality of fibers forming a shape for augmenting fixation of a bone screw, or the plurality of fibers form a shape having a peg portion and a sheet portion to augment tendon to bone repair. The physical presence of the plurality of fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the site of the bone screw or the tendon to bone repair.

A humeral implant is disclosed. The implant has a humeral surface component and a stem. The humeral surface component has an articular surface and is configured for fixation to an articular portion of a proximal humerus. The stem is configured for post-surgery axial movement within the humerus. The stem is connected to the humeral surface component opposite of the articular surface. A method of implanting a humeral implant is also disclosed.

Implants including non-resorbable frameworks and resorbable components, as well as methods of use thereof are disclosed. The embodiments include different combinations of a non-resorbable framework (in some case structural and in other cases non-structural), and a resorbable component embedded within and/or around the framework (again, in some cases structural and in other cases non-structural). The disclosed implants provide an efficient means of providing structural support for the vertebral bodies post-implantation, as well as encouraging resorption of the implant and fusion of the associated vertebral bodies without negative side effects and/or failure, such as subsidence of the implant or cracking/fracturing of a portion of the implant when implanted.

Arthroplasty implant systems and methods are provided for restoring the functionality of a joint. The arthroplasty implant systems may include a threaded cup having a cylindrical shaped body and a flange. A thread may be provided on the cylindrical shaped body. The thread is configured to engage a bone, and the flange is configured to engage a cortical rim of the bone.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

A medical implant system is described for inhibiting infection associated with a joint prosthesis implant. An inventive system includes an implant body made of a biocompatible material which has a metal component disposed on an external surface of the implant body. A current is allowed to flow to the metal component, stimulating release of metal ions toxic to microbes, such as bacteria, protozoa, fungi, and viruses. One detailed system is completely surgically implantable in the patient such that no part of the system is external to the patient while the system is in use. In addition, externally controlled devices are provided which allow for modulation of implanted components.

The present invention provides scaffolds comprising dual structural organization for bone and regeneration. Methods for fabricating and using the scaffold are also disclosed.