This application is directed to a device comprising a covering attached to the device. A process of making a device with a specific covering attached is also disclosed. The application further discloses a method for the treatment of perforations, fistulas, ruptures, dehiscence and aneurisms in luminal vessels and organs of a subject.

An implantable stent includes multiple circumferential segments that surround a bore and are connected in series along a length to form a tubular wall. Multiple adjacent alternating opposite facing crowns arranged along each segment's circumference are bridged by struts. The struts include a series of staggered arcuate edges with limited flats to provide a limited region of maximum width between significantly extended reducing diameter tapers at either end where they transition into the crowns. Connections between adjacent segments are wider and stiffer than the struts and strut-crown transitions in the segments. The crowns include inner and outer radii with off-set centers along a common axis to provide medial crown peaks along the axis that are wider than the narrowed crown shoulders on either side of the axis and from which the tapered struts extend. Material strain and flexure along the stent during lateral bending is distributed mainly within the segments, e.g. along the struts or crowns, versus at the connections between segments. Material strain and deformation during radial expansion is principally concentrated at the crown shoulders and tapered transition region with the struts. Particular closed-open-closed arrangements along the stent length are disclosed, though with fewer stent connections in the relatively closed end-portions along the stent than are provided by other typically open cell stents in prior use. Enhanced combinations of performance characteristics are provided regarding visibility, trackability, expansion characteristics, fatigue failures, coating integrity, and local drug delivery from the stent.

Apparatus and methods are provided for treating patients exhibiting symptoms of hypertension, isolated systolic hypertension, heart failure with preserved ejection fraction, May-Thuner Syndrome or dyspnea by diagnosing and reducing narrowing of a patient's iliac vein caused by extrinsic localized compression using a stent having circumferential differential radial stiffness and delivery catheter for aligning and deploying such stents.

An endoluminal prosthesis system for a branched body lumen comprises a branch vessel prosthesis. The branch vessel prosthesis is deployable within a branch vessel body lumen and comprises a stent having a generally tubular body portion, a flareable proximal end portion, and a coupling portion disposed intermediate the body portion and the flareable portion. The coupling portion is more crush-resistant than the body portion. The flareable proximal end may be disposed within a fenestrated stent graft with coupling portion disposed in the fenestration of the fenestrated stent graft.

A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provide high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold is typically formed from non-degradable material and will be modified to expand and/or uncage after deployment.

A vascular stent, including a plurality of wave-shaped supporters connected in an axial direction. The tubular stent includes a proximal support mechanism, a middle support mechanism, and a differential support mechanism connected in sequence; the middle support mechanism and the distal support mechanism are respectively closed-loop structure; the proximal support mechanism includes a first support portion connected to the middle support mechanism and a second support portion provided at the proximal end of the first support portion; the first support portion is a closed-loop structure; the second support portion is an open-loop structure, and the end surface of the proximal end of the second support portion is an uneven structure to provide local support in the circumferential direction.

A stent that has a reduced state, an expanded state, and a delivery state, includes helical windings, a bridge, and a sacrificial bridge. The helical windings define a cylinder with a helical axis including a strut having a straight portion connected to a curved portion, wherein the straight portion aligns with the helical axis. The bridge connects adjacent windings. The sacrificial bridge connects adjacent windings and is configured for removal in the expanded state.

Apparatus and methods are described including an implantable device shaped to define (a) at least two artery-contact regions, the artery-contact regions comprising struts that are configured to stretch an arterial wall by applying pressure to the arterial wall, and (b) at least two crimping regions that comprise locking mechanisms configured to prevent the crimping regions from becoming crimped due to pressure from the wall of the artery on the artery-contact regions. The crimping regions are configured to be crimped during insertion of the device, via a catheter, by the locking mechanisms being unlocked during insertion of the device. Other embodiments are also described.

A tubular prosthesis having at least two helical loops or discrete loops, linked by a bridge, includes at least two regular struts connected by a regular inflection point forming a regular gap between the regular struts and at least two stagger struts connected by a stagger inflection point forming a stagger gap wherein the regular gap has a size different from the stagger gap.

Self-expending stents that include circumferential rings of alternating interconnected struts connected by flexible connectors. The struts of the rings and flexible connectors have a structure, including areas of expanded or reduced width or thickness, to account for venous applications. When used for venous applications, the stents convey benefit from configurations that improve flexibility (due to the greater elasticity of venous applications) while maintaining enough stiffness to resist pressure on the venous structure in selected areas (such as for the May-Thurner syndrome). The stents include particular structural characteristicsoften expressed as ratios between different measurementsthat are particularly advantageous for (although not limited to) venous applications.