The present invention provides an epidermal penetration type ink composition comprising: a fluorescent colorant containing at least one selected from the group consisting of indocyanine green (ICG), cyanine, phthalocyanine, oxazine, rhodamine, and a mixture thereof; a binder resin containing at least one of polyvinylpyrrolidone (PVP) and polyvinylbutyral (PVB); and a solvent containing at least one of ethanol and isopropanol.

There is provided a novel conjugate that binds to the cell surface receptor uPA (uPAR). The conjugate is based on a fluorescence-labeled peptide useful as a diagnostic probe to the surfaces of cells expressing uPAR. The conjugate is capable of carrying a suitable detectable and imageable label that will allow qualitative detection and also quantitation of uPAR levels in vitro and in vivo. This renders the surgical resection of tumors more optimal.

The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatible macromolecule.

The present invention provides nanomaterials for the specific targeting of immune cells. Methods of treating cardiac disease and inflammatory disease are also described.

The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

A system and a method for automatically and continuously measuring and assessing hemodynamics uses fluorescence imaging in which the fluorescent agent is controlled and automated. A method of automatic perfusion assessment of an anatomical structure of a subject includes administration into a vein of a bolus corresponding to less than 0.01 mg ICG/kg body weight of a first fluorescence imaging agent. A system for automatic perfusion assessment during a medical procedure includes a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of the first fluorescence imaging agent into the blood. The system is configured for receiving and analysing a time series of fluorescence images and determining at least one perfusion parameter based on the analysis.

A system for fluorescence guided surgery which includes alternatingly obtaining white light images and blue light images and simultaneously displaying those images on a display screen, such that a surgeon is presented with immediate, real-time video which shows the target tissue under white light and fluorescing tissue under blue light on the same screen, at the same time. The images may be presented side-by-side, or superimposed.

This invention relates to, in part, methods and compositions that are useful for the diagnosis, treatment, or prevention of a blinding eye disease, including in the discovery of drugs that are efficacious against these diseases. Diseases include, for example, age related macular degeneration and reticular pseudodrusen disease, and the methods described herein include, for example, the method named delayed near infrared analysis (DNIRA).

A surgical visualization and medical imaging device and related computer based imaging methods and systems are disclosed. The surgical devices of the present invention use indocyanine green dye combined with a plastic, and are used in enhanced surgical imaging in applications such as robotically assisted surgeries. A near infrared light source, such as an 805 nm laser, may be used to excite the surgical device so that the device emits 835 nm light. Both the excitation and emission wavelengths penetrate tissue and blood, and provide enhanced imaging of surgical procedures. The resulting fluorescence image allows a user to readily determine relative tissue depth, to identify tissue inhomogeneity, to detect masses or tissue irregularities, to pinpoint anatomical holes, and to visualize tears.

Proteinoid compounds characterized by a molecular weight (Mw) of at least 15,000 Da, processes of preparing such compounds and methods of use thereof, are provided. A method of monitoring the presence and metastases of cancer in a body of an individual is further disclosed.