A plunger sub-assembly (40, 60, 70; 80) for a pre-filled medicament injector for expelling a dose of a medicament, comprising: a) a container (60) holding a medicament, the container (60) comprising a body (61) with a proximally facing rim surface (64), and a distally slideable piston (63); b) a plunger (40); and c) a tolerance compensating element (70; 80) configured to cooperate with the plunger (40) and to cooperate with either the proximally facing rim surface (64) or the piston (63), the tolerance compensating element (70; 80) being rotatable relative to the plunger (40) to adjust the piston (63) end of dose position. The plunger sub-assembly (40, 60, 70; 8) is formed so that end of dose state occurs by the plunger (40) cooperating with the proximally facing rim surface (64). Pre-filled medicament injectors and methods of assembling a pre-filled medicament injector are further described.

An injection device incorporating a dose setting mechanism is presented where the dose setting mechanism contains a fail safe feature that activates during an interrupted dose delivery event. A dose selector having a projecting rib engages a protrusion on a snap element to prevent the dose knob from moving distally if a user removes an axial force in the proximal direction during dose delivery. The dose setting mechanism can further include a reuse prevention feature.

A dose setting mechanism for a drug delivery device includes a primary drug delivery assembly and a secondary drug delivery assembly. The dose setting mechanism includes a primary dose dial component for setting a dose in the primary drug delivery assembly and a secondary dose dial component for setting a dose in the secondary drug delivery assembly. The primary dose dial component and the secondary dose dial component are configured to rotate during dose setting. A gear mechanism is configured such that in a first phase of the dose setting, rotation of the primary dose dial component is transferred to the secondary dose dial component and such that in a second phase of the dose setting, the secondary dose dial component is decoupled from the primary dose dial component such that rotation of the primary dose dial component is prevented from being transferred to the secondary dose dial component.

A setting mechanism for a dosing device, in particular for a device for dosing pharmaceutical or therapeutic substances, the setting mechanism including: a controlling assembly for connecting the setting mechanism with a dose setting element of the dosing device; a driving assembly for connecting the setting mechanism with a driving element of the dosing device; a dosing assembly for connecting the setting mechanism with a dosing element of the dosing device. The controlling assembly is coupled with the dosing assembly by a spring element, which can deform from a coupled position to a decoupled position during rotation of the dose setting element. The spring element is configured to allow a displacement of the controlling assembly with respect to the dosing assembly. In the coupled position the spring element is configured to block a rotation of the controlling assembly with respect to the dosing assembly.

The disclosure is directed to a differential gear mechanism for a drug delivery device with a primary drug delivery assembly and a secondary drug delivery assembly, wherein the primary drug delivery assembly comprises a primary dose dial sleeve and wherein the secondary drug delivery assembly comprises a secondary drive sleeve. The disclosure is also directed to a respective drug delivery device.

A portable device that accurately determines the liquid dosage that a patient is consuming while also regulating their use of the device is provided and is suitable for use with substances like medical cannabis and opioids. A liquid dispenser device is reusable with replaceable liquid cartridges. These cartridges can contain multiple dosages of a specific liquid, which is more convenient for the patient and reduces cost. The device uses a micro-motor, translational screw, and encoder to determine the exact amount of liquid displaced from the cartridge. That exact amount of liquid is dispensed from a small nozzle into a mouthpiece. The mouthpiece is replaceable and can be tailored to meet the patient's specific needs. For example, the mouthpiece can be adapted for dispensing under the tongue of the user or directly into a drink. The device can also have locking mechanisms and wireless communication capabilities. The device will not allow patients take over the maximum doctor recommended dosage, and regulates the time interval of those dosages based on doctor recommendation. Wireless communication can be used to communicate with other devices to ensure that the patient is not overlapping their dosages. Wireless communication can also be used to sync the device to a smartphone, tablet, or computer app to track patient data, usage, and the patient can also set a timer/alarm.

A setting mechanism for a dosing device, in particular for a device for dosing pharmaceutical or therapeutic substances, the setting mechanism including: a controlling assembly for connecting the setting mechanism with a dose setting element of the dosing device; a driving assembly for connecting the setting mechanism with a driving element of the dosing device; a dosing assembly for connecting the setting mechanism with a dosing element of the dosing device. The controlling assembly is coupled with the dosing assembly by a spring element, which can deform from a coupled position to a decoupled position during rotation of the dose setting element. The spring element is configured to allow a displacement of the controlling assembly with respect to the dosing assembly. In the coupled position the spring element is configured to block a rotation of the controlling assembly with respect to the dosing assembly.

An autoinjector comprising: a body (1) receiving a reservoir (S), said reservoir (S) containing fluid and including a piston (P), such as a pre-filled syringe; a piston rod (5) that is adapted to co-operate with the piston (P) of said reservoir (S), said piston rod (5) being movable by an injection spring (8) between a primed position and an injection position in which said piston rod (5) has moved the piston (P) of the reservoir (S) so as to inject the fluid into an injection site; and a visual, audible, and/or tactile indicator device for indicating to the user that said autoinjector may be removed from said injection site;

said autoinjector including a retarding system for delaying the actuation of said visual, audible and/or tactile indicator device relative to the end of injection, said retarding system including a dashpot (16) containing a fluid, a piston (19) being arranged in said dashpot (16), one of said dashpot (16) and of said piston (19) being movable in translation in said body (1) during actuation of said retarding system, and the other of said dashpot (16) and of said piston (19) being stationary relative to said body (1) during actuation of said retarding system, the movement in translation of one relative to the other moving said fluid out from said dashpot (16) through at least one flow passage (161; 195), such that said movement in translation is braked, said retarding system comprising said dashpot (16) containing said fluid, said piston (19), a retarding spring (18) that is fastened firstly to said piston (19), and secondly to said body (1), a locking key (20), and said piston rod (5), and said piston rod (5).

Disclosed herein is a drug delivery device with a primary drug delivery assembly for the delivery of a primary medicament, with a primary dose setting member; and a secondary drug delivery assembly for the delivery of a secondary medicament with a secondary dose setting member. A dose dial is rotationally constrained with respect to the housing in a first axial position and is rotationally constrained to the primary dose setting member in a second axial position. A bridging component is axially constrained to the dose dial to set a dose of the secondary medicament, wherein rotation of the dose dial to set a dose of the primary medicament causes the dose dial to move relative to the bridging component in axial direction.

An autoinjector comprising: a body (1) receiving a reservoir (S), said reservoir (S) containing fluid and including a piston (P), such as a pre-filled syringe; a piston rod (5) that is adapted to co-operate with the piston (P) of said reservoir (S), said piston rod (5) being movable by an injection spring (8) between a primed position and an injection position in which said piston rod (5) has moved the piston (P) of the reservoir (S) so as to inject the fluid into an injection site; and a visual, audible, and/or tactile indicator device for indicating to the user that said autoinjector may be removed from said injection site;

said autoinjector including a retarding system for delaying the actuation of said visual, audible and/or tactile indicator device relative to the end of injection, said retarding system including a dashpot (16) containing a fluid, a piston (19) being arranged in said dashpot (16), one of said dashpot (16) and of said piston (19) being movable in translation in said body (1) during actuation of said retarding system, and the other of said dashpot (16) and of said piston (19) being stationary relative to said body (1) during actuation of said retarding system, the movement in translation of one relative to the other moving said fluid out from said dashpot (16) through at least one flow passage (161; 195), such that said movement in translation is braked, said retarding system comprising said dashpot (16) containing said fluid, said piston (19), a locking key (20), said injection spring (8), a pusher element (17), a support member (6) interposed between said pusher element (17) and said injection spring (8), and said piston rod (5).