A system for medication delivery comprises a Package containing a medication and a Dosing mechanism for delivering a dose of a drug, formulated as multiparticulate, microspheres, powder or liquid. The Package comprises a bottle, a bottle insert that covers the bottle opening and includes a dispense nozzle. The dispense nozzle is sealed using a valve that opens when the Dosing device is engaged with the bottle. A closure covers the bottle insert and closes the bottle. The Dosing device, similar to an oral syringe, comprises a barrel with a valve at its distal end, a plunger and a dose control clip for attachment to the plunger. After the dosing device is connected to the bottle valve, withdrawal of the plunger causes the dosing device to receive a dose of drug, the user pushes the plunger which pushes the MP drug through the valve and into a patient's mouth.

A drug delivery device for dispensing of a dose of a medicament includes a housing extending in an axial direction and a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction. The drug delivery device includes a dose indicating mechanism including a first spool and a second spool rotatably supported in the housing and a dose indicating tape coiled onto at least the second spool and fixed with an end to an outer circumference of the first spool. The first and second spools are oriented substantially parallel to each other and substantially parallel to the piston rod.

The invention refers to an injection device comprising a housing (10), containing a cartridge (170) with an amount of liquid to be dispensed, a drive sleeve (41), which is rotationally constrained to the housing (10) during dose setting and spring driven rotatable relative to the housing (10) during dose dispensing, a dose dial member (60) for setting a dose to be dispensed, which is rotatable relative to the housing (10) during dose setting and during dose dispensing, and which is rotationally coupled to the drive sleeve (41) during dose dispensing. The device further comprises a last dose protection mechanism (41, 50, 60) for preventing the setting of a dose, which exceeds the amount of liquid left in the cartridge (170), with a limiter (50), which is interposed between the drive sleeve (41) and the dose dial member (60). Further, the device comprises two different display members (110, 120), each indicating the set dose.

A drug delivery device with a housing configured to connect to a dispensing unit includes a compartment containing a fluid, a piston rod configured to move in a proximal direction for ejecting the fluid, and a dosing mechanism comprising an actuation member to be actuated by a user. The device includes a conversion mechanism configured to convert a movement of the actuation member to a movement of the piston rod. The conversion mechanism includes a dose selector member, which is rotationally fixed to the housing and axially movable with respect to the housing, and a dosing member, which is rotationally movable with respect to the dose selector member. The drug delivery device includes a friction reduction mechanism provided between the dose selector member and the dosing member to reduce friction between the dose selector member and the dosing member.

A drug delivery device has a housing with a longitudinal axis, a dose setting member actuatable by a user and rotatable around the longitudinal axis to set a dose to be delivered by the drug delivery device, a piston rod that is configured to be axially advanced in a proximal direction to deliver the set dose, and a dosing member for defining the axial advancement of the piston rod upon delivery of the set dose. The dosing member is axially movable along the longitudinal axis and rotationally movable around the longitudinal axis during dose setting, and the dosing member is rotationally fixed to the dose setting member during dose setting. The dosing member comprises a maximum dose stop that is configured to engage with a maximum stop feature provided at the housing to limit movement of the dosing member with respect to the housing upon setting a maximum dose.

A drive mechanism for a drug delivery device includes an elongated housing extending in an axial direction and a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction. A drive sleeve is rotatably supported in the housing, operably releasable from the piston rod for setting of a dose, and operably engageable with the piston rod for dispensing of the dose. A dose limiting member is engaged with the drive sleeve and engaged with the piston rod in such a way that it is displaced in axial direction relative to the drive sleeve when the drive sleeve rotates relative to the piston rod during a dose setting procedure. At least one stop is configured to engage with the dose limiting member for limiting the axial displacement of the dose limiting member during the dose setting procedure and to impede further displacement of the drive sleeve relative to the piston rod.

Ratchet-based drive systems for more reliable and safer drug delivery are provided. The ratchet-based drive systems restrict angular movement and/or linear movement of components that cause a plunger to expel a liquid drug from a drug container. Movement of the components can be restricted to correspond to a predetermined or desired portion of the liquid drug. In the case that control of the drive system is lost or fails, the maximum amount of drug that could be delivered is limited to a known amount, thereby reducing the likelihood of an overdose.

The present invention relates to an injection device (1) for setting and injecting set doses from a held drug cartridge (10). The injection device (1) comprises a housing (110,120,130, 140), a piston rod (800), a rotatable driver (500, 700) and a dose setting device (400). The dose setting device (400) comprises a predetermined stop to limit the amount of an expelled dose corresponding to the amount of a set dose. A secondary stop limiter includes first (700) and second (270) components and a secondary stop track follower (950) arranged between the first (700) and second (270) components. If the predetermined stop fails to stop the driver (500, 700) at the end of injection, the secondary stop track follower (950) moves towards a safety stop (708) to prevent the driver (500, 700) from rotating further.