A method of providing and/or injecting octreotide acetate to a subject in need thereof includes storing the octreotide acetate in a cartridge of a multi-use multi-dose injector provided with a variable dose setter and actuator. The injector includes a needle configured for subcutaneous administration of the octreotide acetate, the octreotide acetate having a concentration of 2,500 μg/mL. The method further includes providing, on the injector, a plurality of indicia only at prescribed doses of 50 μg, 100 μg, 150 μg and 200 μg settable via the dose setter without indicia between said prescribed doses; and permitting setting of a dose of the octreotide acetate by rotation of the variable dose setter, wherein the injector is configured to provide at least one audible feedback during the rotation.

A drug delivery device with a housing configured to connect to a dispensing unit including a compartment containing a fluid, a piston rod configured to move in a proximal direction for ejecting the fluid, and a dosing mechanism including an actuation member to be actuated by a user. The device includes a conversion mechanism configured to convert a movement of the actuation member to a movement of the piston rod. The conversion mechanism includes a dose selector member, which is rotationally fixed to the housing and axially movable with respect to the housing, and a dosing member, which is rotationally movable with respect to the dose selector member. The drug delivery device includes a friction reduction mechanism provided between the dose selector member and the dosing member to reduce friction between the dose selector member and the dosing member.

A kit includes a drug delivery device and a dispensing unit. The drug delivery device includes a housing, a resetting element and a piston rod and the dispensing unit includes a cartridge holder. The cartridge holder is configured to be mounted to the housing and to receive a cartridge filled with a drug. The piston rod is configured to move in a proximal direction out of the housing to eject the drug and the resetting element is configured to rotate relative to the housing when no dispensing unit is attached to the housing and to thereby move the piston rod back into the housing. The dispensing unit is configured to press axially against the resetting element upon mounting to the housing to move the resetting element in the distal direction into the housing, and thereby rotationally lock the resetting element with respect to the housing.

A drug delivery device has a housing with a longitudinal axis, a dose setting member actuatable by a user and rotatable around the longitudinal axis to set a dose to be delivered by the drug delivery device, a piston rod that is configured to be axially advanced in a proximal direction to deliver the set dose, and a dosing member for defining the axial advancement of the piston rod upon delivery of the set dose. The dosing member is axially movable along the longitudinal axis and rotationally movable around the longitudinal axis during dose setting, and the dosing member is rotationally fixed to the dose setting member during dose setting. The dosing member includes a maximum dose stop that is configured to engage with a maximum stop feature provided at the housing to limit movement of the dosing member with respect to the housing upon setting a maximum dose.

The present invention relates to an injection device comprising a torsion spring operatively connected to a dose setting member being adapted to set a dose to be ejected from the injection device. A rotatably mounted display member adapted to display the dose to be ejected in accordance with a setting of the dose setting member is also provided. The rotatably mounted display member is adapted to be rotated over an angle corresponding to at least one revolution of the display member. The display member may be implemented as a dose indicator barrel having numerals arranged along a helical path on an outer surface thereof, or alternatively, as a counting device having two or more display wheels having numerals arranged on an outer surface thereof.

Variable fill drug delivery devices for delivering a therapeutic agent to a patient are provided. A variable fill drug delivery device includes a drug container to store a variable amount (or user-selectable amount) of a therapeutic agent. A plunger of the variable fill drug delivery device is positioned in the drug container. An infusion engine of the variable fill device is coupled to the plunger. The infusion engine retains the plunger prior to activation of the variable fill drug delivery device and releases the plunger after activation of the variable fill drug delivery device. After activation, the infusion engine drives the plunger from a first position within the drug container to a second position within the drug container to expel the variable amount of the therapeutic agent from the drug container for delivery to a patient.

An injection device (102) comprising: an energy source (104) configured to power an electronic system (105) of the injection device (102); one or more sensors (127a, 127b, 28b) in communication with the energy source (104), the one or more sensors (127a, 27b, 128b) configured to cause an activation signal to be provided to the energy source (104) to cause the energy source (104) to enter a powered state from a sleep state; and a processor (128a) configured to facilitate one or more functions of the injection device (102) when the injection device (102) is in the powered state.

The present disclosure relates to a dose detection system for use with a medication delivery device in which a dose setting member rotates relative to an actuator during dose delivery. The dose detection system comprises a module including a rotation sensor attached to the actuator during dose delivery. A sensed element is attached to the dose setting member and includes first gear teeth. The rotation sensor comprises a driven gear including second gear teeth. The second gear teeth are operatively received by the first gear teeth and are driven in rotation as the first gear teeth rotate during dose delivery. The rotation sensor is responsive to the rotation of the second gear teeth to detect the rotation of the dose setting member.

A supplemental device for attachment to an injection device, the supplemental device having a housing containing at least two electromechanical switches each having an open state and a closed state and a protrusion associated with each switch configured to protrude from the housing so as to contact a rotatable surface of the injection device while the supplemental device is attached to the injection device; and a processor arrangement configured to detect a change in the state of each of the switches; and to determine a direction of rotation of the rotatable surface of the injection device from the detected state changes.

A supplemental device for attachment to an injection device, the supplemental device having a housing containing at least two electromechanical switches each having an open state and a closed state and a protrusion associated with each switch configured to protrude from the housing so as to contact a rotatable surface of the injection device while the supplemental device is attached to the injection device; and a processor arrangement configured to detect a change in the state of each of the switches; and to determine a direction of rotation of the rotatable surface of the injection device from the detected state changes.