The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose-cartridge and permit a user to set the delivery dose. The injector may include a housing, a piston rod adapted to operate through the housing, a dose dial sleeve located between the housing and the piston rod, and a drive sleeve located between the dose dial sleeve and the piston rod. The dose dial sleeve may have a helical thread of first lead and the drive sleeve may have a helical groove of second lead. The first lead of the helical thread and the second lead of the helical groove may be the same.

The invention relates to an injection unit, preferably a pen-shaped injection unit, for administering or delivering a fluid product. The injection unit comprises a housing, an axially movable piston rod mounted in the housing in a non-rotatable manner, a delivery apparatus having a threaded nut that is able to move the piston rod in order to deliver product, a dosing device having a dosing sleeve, a rotary knob, a discharge button arranged coaxially on the dosing sleeve, and a receptacle for the product. The dosing device is connected to the delivery apparatus via a coupling mechanism, wherein the coupling mechanism includes of at least two coupling surfaces that each carry a toothing comprising teeth, wherein the coupling surfaces are used to generate an acoustic and/or tactile signal corresponding to the set or corrected dose of the product to be administered during the dosing operation or during correction of the dose.

Injection device for delivering a defined number (n) of equal doses of a fluid substance contained in a reservoir (P), the device having a housing (1) within which an arming mechanism and a dose delivery mechanism are arranged along the longitudinal axis of the housing, the housing (1) being coupled to an enclosure (3) adapted for receiving the reservoir (P) with the fluid substance, the arming mechanism comprising a setting sleeve (5) which is axially non-displaceable and rotatable around the axis of the housing in two opposite directions by a defined setting angle (a), the setting sleeve (5) being coupled with a spring (10) which is strained by the rotation of the setting sleeve (5) during arming of the device; the dose delivery mechanism comprising a screw ring (6) and a piston rod (4) which is non-rotatable and axially displaceable within the setting sleeve (5), the piston rod (4) cooperating with the screw ring (6) so that during arming of the device the screw ring (6) and the piston rod (4) are immobilized, and during delivery of each dose the piston rod (4) is displaced along the housing (1) by a defined distance due to unwinding of the spring (10) and rotation of the screw ring (6), the displacement of the piston rod (4) causing the fluid substance to be discharged from the reservoir (P). The injection device according to the invention is provided with blocking means preventing arming of the device for delivery of a subsequent dose after said defined number (n) of doses of a fluid substance have been delivered, the blocking means comprising at least one longitudinal protrusion (5.1) located near the distal end of the setting sleeve (5) on its inside surface, and at least one longitudinal arm (4.2) located at the proximal end of the piston rod (4), the at least one longitudinal protrusion (5.1) and the at least one longitudinal arm (4.2) mutually blocking each other after said defined number (n) of doses of a fluid substance have been delivered which prevents rotation of the setting sleeve (5) by the entire setting angle () in the arming direction.

The fluid delivery pen of the present invention has a reduced dose setting friction mechanism which may produce a sound of higher audibility for each click corresponding to one unit dose set using a dose setting mechanism and also produces a sound of lower audibility than the former for each click when the set dose is reduced using the dose setting mechanism. The fluid delivery pen driving mechanism of the present invention has an indication to an end of dose of fluid in a cartridge.

A metered droplet medicament delivery device for delivering metered doses of medicament includes a proximal part and a distal part having opposite distal and proximal ends; a medicament container with a movable stopper; and a dose delivery mechanism that includes a plunger rod, operably arranged to act on the stopper. The proximal and distal parts are releasably connectable to each other. The proximal part includes a medicament container holder accommodating the medicament container, and the distal part includes the dose delivery mechanism. A plunger rod positioning member is engageable with a proximal end of the plunger rod and with a proximal area of the distal part for positioning the plunger rod in a longitudinal direction in relation to the proximal area.

A dispensing mechanism for administering a dosage of a medicament includes dosage setting means (7) for setting the dosage of a medicament to be administered; expelling means (15) for expelling a medicament from a medicament container; and coupling means (21) operatively coupled with the dosage setting means (7) and the expelling means (15), wherein the coupling means (21) is arranged to convert displacement of the dosage setting means (7) into a displacement of the expelling means (15) in a first direction, wherein the expelling means (15) includes a ratchet means (18a, 18b), and wherein the mechanism includes a first and a second independently moveable resisting pawl (14a, 14b) means facing a common side of the ratchet means (18), the first and the second resisting pawl means (14a, 14b) being configured to engage with the ratchet means (18a, 18b) and resist displacement of the expelling means (15) in a second direction opposite to said first direction.

A medication delivery device is disclosed including a rack-and-pinion plunger drive system. The drive system includes an output drive having a pawled end movably coupled with the ratchet teeth of the plunger, and a pinion drive coupled between the housing, the output drive and an actuator. Actuator is longitudinally movable between dose set and delivery positions. Movement of the actuator causes rotation of the pinion drive along the rack to translate the output drive member with the pawled end that is engaged with the plunger ratchet teeth to distally advance the plunger. The device may include one or more of an end of dose mechanism to limit travel of the actuator, a load brake system to stop travel of the plunger under high input forces, a dose detection system, and a dose selector to vary the amount of dose set.

Sensing systems, devices and methods are disclosed for determining the relative movement of first and second members of a medication delivery device which are proportional to the amount of a dose set and/or delivered by operation of the medication delivery device. A sensor is coupled with the first member. A pair of targets is coupled with the second member. Each target comprises an array of teeth which move through an area sensed by the sensor. The sensor thereby detects characteristic values of a sensed parameter corresponding to the combined relative positions of the first and second members. The sensing system outputs this information to a processor which determines the amount of the dose set and/or delivered. Related medication delivery devices and methods are also disclosed.

The present disclosure is directed to a dose setting mechanism that may be used with a drug delivery device. The dose setting mechanism may include an inner body having a helical thread along an outer cylindrical surface of the inner body, and a drive sleeve for driving a piston rod in an axial direction, the drive sleeve positioned within at least a portion of the inner body. The dose setting mechanism may further include a dose dial sleeve rotatably engaged with the helical thread of the inner body and a dial grip connected to the dose dial sleeve and releasably connected to the drive sleeve. Further when a dose is set, the dial grip is rotated so that both the dose dial sleeve and the drive sleeve rotate with respect to the inner body.

A drug delivery device comprises a medicament reservoir attached to a housing, a drive mechanism comprising a plunger movable relative to the housing, a dose selecting element releasably coupled to the drive mechanism and rotatable relative to the housing, a trigger axially movable relative to the housing, and a limiter selectively permitting and preventing axial movement of the trigger depending on the amount of a selected dose. The limiter is constrained to the dose selecting element and to the trigger. One of the limiter or a component part is axially coupled to the housing comprises a track which is in engagement with a blocking feature of the other of the limiter or the component part axially coupled to the housing. The track comprises a narrow section limiting relative movement between the track and the blocking feature and a wide section permitting relative movement between the track and the blocking feature.