Injection devices are provided which include a handpiece capable of housing a cartridge containing an injectable composition, and a head coupled to the handpiece and housing a plurality of retractable needles and a dosing mechanism. Methods of treating skin surfaces are also provided.

A medical injection assembly is provided and includes an introducer with a handle, a sheath, and a scope lumen extending from a first proximal end of the handle to a distal end of the sheath, wherein the scope lumen is configured to receive an endoscope at the first proximal end of the handle and hold the endoscope in a desired position. The introducer includes a cannula lumen extending from a second proximal end of the handle to the distal end of the sheath, wherein the cannula lumen is configured to receive a cannula at the second proximal end of the handle and hold the cannula in a desired position. The medical injection assembly includes a cannula configured such that the distance between the distal tip of the cannula and the axis defined by the sheath of the introducer increases as the cannula is moved in a distal direction.

A system and method for delivering a therapeutic agent such as filler materials, biocompatible gels, and other substances through a catheter. The therapeutic agent can be a single component or multiple components that are delivered separately or mixed just prior to delivery or at the delivery site. The system and method use an automated delivery mechanism to maximize delivery of the therapeutic agent to the target tissue and minimize loss of the therapeutic agent within the catheter. The system and method are particularly useful for interventional approaches that deliver therapeutic agents to the wall of the heart.

A telescopic screw assembly for an injector includes an inner screw, an outer screw and a middle screw. The middle and outer screws are in a first threaded engagement, and the inner and middle screws are in a second threaded engagement. The inner screw is nested with the middle screw and the middle screw is nested with the outer screw in a contracted configuration of the screw assembly. Rotation of the outer screw in one direction advances the middle screw relative to the outer screw via the first threaded engagement and advances the inner screw relative to the middle screw via the second threaded engagement to telescopically extend the screw assembly into an expanded configuration. At least two of the inner, middle and outer screws are identified with a different visual indicator to enhance visual distinction between the screws, and readily visually indicate an extension progress of the screw assembly.

An automatic injector includes a housing having a guide, a drive control mechanism, a transmission assembly, a motor, and an energy source. The housing may further include a cartridge cover. A drive control mechanism includes a drive screw, a cartridge carrier, a plunger carrier, and one or more control transfer instruments, such as a puck or cylinder. The drive screw interfaces and connects with the plunger carrier. The automatic injector is configured to accept a variety of syringes as cartridges for drug delivery. The cartridges may be ejected from the injector and safely disposed after use, making the injector a reusable automatic injector. The reusable automatic injector may further include one or more sensors, such as a cartridge sensor and a patient sensor. The novel incorporation of the drive control mechanisms into the automatic injectors of the present invention enables a single motor and transmission assembly to drive the function of multiple components, which may include the steps of: preparation and alignment of a cartridge for injection, removal of a safety cap or needle shield, needle injection, drug dose delivery, and syringe and/or needle retraction. Methods of manufacture and methods of use are also disclosed.

A syringe having a dispensing element (20) and having a mounting element (2), wherein the dispensing element (20) has a dispensing sleeve (21) and a leaf spring system (3), wherein the mounting element (2) has a syringe body (17), and an injection needle (16) is formed on one end on the syringe body (17) and a detent-engagement flange (19) is formed on the other end, wherein, in the syringe body (17), there is arranged a movable stopper (18), wherein the leaf spring system (3) comprises a piston (6) and a spiral spring (5) arranged around the piston (6), wherein the piston (6) can be slid into the dispensing sleeve (21), and the spiral spring (6) is arranged between a leaf spring base (22) and a spiral spring abutment, wherein the piston (6) abuts against the stopper (18), wherein the dispensing sleeve (21) has a guide duct and the dispensing sleeve (21) comprises a first locking means (7) and a second locking means (9), wherein the detent-engagement flange (19) is movable in the guide duct and is fixable and releasable at the first locking means (7) or the second locking means (9).

Provided herein are methods for providing a therapeutic benefit to a patient. A method of treating a patient with a metabolic disease and/or a pancreatic disease includes: selecting a patient with a metabolic disease and/or a pancreatic disease; selecting one or more pancreatic deposit sites; advancing a depositing device comprising a at least one depositing element to the selected one or more pancreatic deposit sites; and delivering a treatment agent through the at least one depositing element into the selected one or more pancreatic deposit sites. Systems and devices are also described.

Devices and methods are provided for delivering an agent into a patient's body using an injection device that includes a drive module and an injector module coupled to the drive module. The drive module includes a canister and puncture mechanism in a first chamber, a plunger in a second chamber communicating with the first chamber, and an actuator that moves the puncture mechanism to cause a puncture pin thereon to penetrate a septum of the canister and cause the gas within the canister to flow through the first chamber around the canister, and into the second chamber. The injector module includes a piston slidably disposed within an agent chamber and coupled to the distal end of the plunger such that, when the plunger moves from a retracted position to an extended position, the piston is advanced within the agent chamber to deliver an agent therein into a patient's body.

This invention is designed and intended to provide simple, precise delivery of a variety of medications to mucosal surfaces of a living subject, human or non-human animal, including but not limited to the nasal or rectal mucosa, which sites afford rapid absorption and therefore onset of effect of the thus delivered medication. Such medications include, but are not limited to, anticonvulsants, drugs to treat anaphylactic shock, antidotes for poisoning, and medications which are required urgently where either a parenteral formulation is not available or an i.v. route is difficult. Simplicity and needle free safety of use of the various embodiments of the invention allows its operation by laypersons, school-teachers, nurses, paramedics and nonmedical persons in e.g. the armed service. Modular embodiments of the invention facilitate mixing and matching of delivery systems with different dosages and types of medications.

A medical injector has a body with a displaceable plunger. The plunger includes a plurality of spaced-apart ratchet teeth disposed along the length thereof. At least one indexer is provided to engage the plunger, wherein the indexer is configured to allow the plunger to displace distally toward a distal end of the body but not proximally toward a proximal end of the body. The medical injector also includes an actuator having an engagement portion formed to engage one or more of the ratchet teeth. The actuator is displaceable to a ready state, the engagement portion being displaced proximally relative to the plunger with the actuator being displaced to the ready state. The indexer prevents proximal movement of the plunger, thereby allowing the engagement portion to bypass one or more of the ratchet teeth with the actuator being displaced to the ready state. In addition, the actuator is displaceable from the ready state to cause actuation of the medical injector. The displacement from the ready state causes distal displacement of the engagement portion with the engagement portion engaging one or more of the ratchet teeth and causing distal displacement of the plunger with the engagement portion.