A drive mechanism for a drug delivery device having a rotationally fixed plunger rod driven by a lead screw. The lead screw engages a free lock which is coupled to a release knob. A dose setting dial cooperates with an inner cylinder using a clutch to establish the axial movement of the plunger rod during dose setting and dispensing.

A device for administering an active substance comprises a multi-chamber carpule having a bypass in one wall and at least one first chamber with a solid active substance and a second chamber with a solvent for the active substance, the second chamber being delimited by a first plug arranged distally in the multi-chamber carpule and a second plug arranged proximally therein; a mixing element is rotatably mounted about a rotational axis in relation to the housing and can be rotated about the rotational axis in a rotational direction in order to mix the active substance and the solvent; and a first detent device is provided on the device such that, after the mixing operation, an axial displacement of the distal end of the second plug in relation to the wall of the multi-chamber carpule is blocked in the proximal direction by means of the distal end of the bypass.

An infusion device includes a housing with an interior chamber sized and configured to hold at least a flange and plunger of a syringe, a trigger held by the housing, and a lever in communication with the trigger and including an upwardly extending cam with a cam path having an upper end. The cam is in communication with the flange of the syringe. In response to actuation of the trigger to dispense fluid from the syringe, the upper end of the cam travels upward above the syringe and longitudinally toward a dispensing end of the syringe to linearly translate the plunger of the syringe in a first direction to dispense fluid from the syringe. To refill fluid into the syringe, the upper end of the cam travels downward and longitudinally away from the dispensing end of the syringe to linearly translate the plunger in a second direction to intake fluid.

A syringe fill system is described, which is useful for filling syringes for dental anesthetic applications. The system incorporates capability for push-pull, pull-push, push-push, and pull-pull modes of operation, for loading syringes with compositions comprising multiple fluid components. A syringe fillable by such syringe fill systems is described, providing haptic and audible feedback to a user, to aid in administering precise amounts of therapeutic compositions. Also disclosed are cassette assemblies for use in such syringe fill systems. Such cassette assemblies may be formed of plastic and elastomeric materials of construction, as disposable or single-use components of the syringe fill system.

A syringe fill system is described, which is useful for filling syringes for dental anesthetic applications. The system incorporates capability for push-pull, pull-push, push-push, and pull-pull modes of operation, for loading syringes with compositions comprising multiple fluid components. A syringe fillable by such syringe fill systems is described, providing haptic and audible feedback to a user, to aid in administering precise amounts of therapeutic compositions. Also disclosed are cassette assemblies for use in such syringe fill systems. Such cassette assemblies may be formed of plastic and elastomeric materials of construction, as disposable or single-use components of the syringe fill system.

A handheld injection device includes a housing and a dose indicator positioned within and axially constrained to the housing and rotatable with respect to the housing during dose setting and during dose dispensing. The dose indicator includes a flexible clicker arm which, only during dispense, is displaced in a first radial direction and, when the device reaches its minimum dose position, in a second, opposite radial direction.

A syringe holder for a motorized injection device, the syringe holder being adapted to receive a receptacle intended to contain a fluid or viscous substance, preferably a disposable refillable receptacle or a syringe, as well as being adapted to be mounted on the motorized injection device such that the motorized injection device enables a part or all of the fluid or viscous substance contained in said receptacle to be expelled. The syringe holder includes a first activator portion to control a predefined function of the motorized injection device. The syringe holder is distinguished in that it comprises a second activator portion to control said predefined function of the motorized injection device independently from the first activator portion.

The invention relates to an autoinjector for dispensing a liquid product, in particular a highly viscous medication, comprising: a housing, a product container, which is arranged in the housing and has a slidable piston, wherein the piston can be slid in a dispensing direction in order to dispense the product contained in the product container, a forward drive element, which acts on the piston as the product is being dispensed, a first spring, which is preloaded such that the product can be dispensed from the product container by the sliding of the forward drive element and the piston, and a rotation element, which is operatively coupled to the forward drive element, wherein the first spring acts on the rotation element in such a way that the rotation element is set into rotation in order to dispense the product, wherein the rotation element or the forward drive element has a thread having a variable pitch.

A method and system are disclosed for driving a plunger in a drug reservoir. In some embodiments, a variable friction element interconnects between a pushing shaft and a wall of the reservoir. For example, rotation of a driving element in a first direction relative to the pushing shaft may advance the pushing shaft in the reservoir. The friction element may have increased friction resistance to rotation of the pushing shaft in the first direction in comparison to frictional resistance to advancing the pushing shaft. For example, the increased friction may result from wedging a radial element between the pushing shaft and the wall of the reservoir.

An apparatus for infusing medical liquid may include: a base body, a needle assembly mounted on the base body, a reservoir unit fluidly connected to the needle assembly and having a plunger therein, a driving unit including a rod, which is connected to the plunger and moves along the reservoir unit, and a driving wheel, which has a protrusion and transmits driving force to the rod, and a connection member disposed between the rod and the driving wheel and having a guide groove for guiding the movement of the protrusion.