An injector device includes an injector body that receives a syringe; and an injection assembly being configured to dispense medicament from the syringe in a dispensation step. Certain types of injector devices include a sudden completion indicator that indicates when the injection is completed. Certain types of injector devices are configured to dispense two different medicament formulations having different viscosities from syringes without making any changes to the injector devices other than to switch out the syringes. Certain types of injector devices include safety arrangements that inhibit firing of the injector device until front and rear housing assemblies are disposed in predetermined rotational and axial positions relative to each other.

A drug delivery device includes a dose counting mechanism and an end-of-content or remaining-dose indication. For example, a dose expelling mechanism is coupled to a reciprocating element configured to undergo a predefined motion during each dose expelling action to allow a dose to be expelled. The predefined motion includes displacement in a first axial direction from a first position to a second position followed by displacement in a second axial direction from the second position to the first position, with a counter element being movable in the first axial direction. First and second unidirectional ratchet mechanisms prevent motion in the first axial direction and allow motion in the second axial direction of the reciprocating element relative to the counter element, and vice versa, respectively.

An injection device is disclosed wherein a dose can be set by rotating a dose setting member, whereby a push button is elevated from one end of the device a distance proportional to the set dose from a position fixed relative to the housing, and wherein the set dose can then be injected by pressing the push button back to its non-elevated position, through which motion a screw will move approximately the same distance or a smaller distance. The invention provides a method of reducing the dose force and/or the push-button movement during injection.

Disclosed in some forms is a process of limiting the impact of surgery on a nerve, the process comprising applying a therapeutic substance to the nerve during surgery. In some aspects, disclosed is a formulation for reducing nerve trauma comprising an active pharmacological ingredient adapted to intervene in the activation of pathways of cellular degradation within the nerve and a carrier adapted to reduce dissemination of the active pharmacological ingredient beyond the site at which its effect is intended.

Apparatus and methods for providing controlled pressure-flow pulses which purge a catheter system with turbulent flow flushing. Accomplishment of such controlled pressure-flow pulses is provided by a variety of inventive devices including a special plunger rod for a conventional syringe, other interactive parts for conventional syringes, an in-line catheter attachable device which automatically generates the controlled pressure-flow pulses and also single pulse, digitally operated devices.

Disclosed in some forms is a delivery device for delivering a gel or liquid pharmaceutical to a treatment site, the delivery device including a body extending from a delivery tip, the body defining a cavity for retaining a pharmaceutical or a pre-assembled cartridge holding the pharmaceutical; and a driver for mechanically discharging the pharmaceutical from the cartridge to the delivery tip. In some forms the driver is adapted to release a consistent flow of the pharmaceutical. In some forms the delivery device is biased into a release configuration.

An injection device kit for the self-administration of an injection of solution that includes a body portion configured for engagement with a cartridge containing the solution and an injection needle where the body portion includes an injection component having an actuation mechanism for inserting the injection needle of the cartridge and for injecting the solution in the cartridge and a safety mechanism on the body portion and configured to prevent injection unless released.

Flush syringe assemblies capable of creating pulsatile movement of the plunger rod as it moves in the distal direction within a syringe barrel, while preventing overpressurization of the catheter are provided. An exemplary flush syringe assembly includes a syringe barrel with a first pulsing element and a chamber with flush solution, a plunger rod with a stopper and a second pulsing element that interacts with the first pulsing element to provide an engagement force that causes pulsatile movement of the plunger rod and a thumb press slidably attached to the plunger rod with a pulse control element. The pulse control element is compressible to create a compression force that is greater than the engagement force of the first pulsing element and the second pulsing element.

Plunger rod stops attach to existing syringes to limit the range of motion of the plunger, thereby to precisely control the amount of liquid that can be expelled from the syringe when the plunger rod stop is in place. In some embodiments, plunger rod stop devices generally include a body configured to attach to the plunger, and a stand-off extending from the body, configured to contact the finger flange when the plunger is depressed. In other embodiments, the plunger rod stop attaches to the finger flange or other fixed component of the syringe and the stand-off is configured to contact the plunger or plunger rod. Methods of the invention involve using the devices to interfere with the range of motion of the plunger, then reconfiguring or removing the device to allow the plunger to be moved a predetermined length, which corresponds to a precise dosage amount.

An dual-dose syringe system is an apparatus that includes a tubular housing and a plunger. The tubular housing attaches onto a variety of syringe and needle assemblies and mounts the plunger within the syringe. The tubular housing prevents the plunger from simply traversing into the syringe. The tubular housing includes a first lateral-half portion and a second lateral half-portion that snaps onto each other and encloses a syringe. The tubular housing further includes a key slot that engages the plunger. The plunger includes a plurality of cross bars that predetermine two doses. Each of the plurality of cross bars is positioned perpendicular to a corresponding adjacent bar, forcing a user to purposefully twist the plunger in order to administer a dose. The apparatus further includes at least one spring-loaded barb that prevents the reuse of the apparatus.