A system for mixing drug products and injecting includes a syringe body, proximal and distal stopper members disposed in the syringe body, a plunger member, and a needle hub assembly coupled to the distal needle interface of the syringe body. The proximal and distal stopper members form a proximal drug chamber between there between and a distal drug chamber between the distal stopper member and a distal end of the syringe body. The plunger member includes a needle retention feature, an energy-storage member, and an energy-storage member latching member all disposed in disposed in a plunger interior. First and second sizes of the respective proximal and distal drug chambers can be modified by movement of the proximal and distal stopper members relative to the syringe body. The needle is at least partially retractable into plunger interior upon manipulation of the plunger member relative to the syringe body.

A medicament delivery device comprises a housing and a syringe axially movable in the housing and the syringe having a barrel. The device further comprises a stopper axially movable in the barrel and which separates a first chamber and second chamber from one another. The stopper is axially movable in the barrel in response to a vapour pressure being received in the second chamber. The device also includes a biasing mechanism to axially move the syringe in the housing between a first syringe position and a second syringe position in response to a first reduction in the vapour pressure in the second chamber. In the first syringe position venting of the propellant from the second chamber through a first fluid pathway is permitted to enable the first reduction in the vapour pressure in the second chamber while venting of the propellant from the second chamber through a second fluid pathway is substantially prevented. In the second syringe position venting of the propellant from the second chamber through the second fluid pathway is permitted to enable a second reduction in the vapour pressure in the second chamber.

The insertion device has a support wall on the site, a receiving body having a guiding housing, the needle housing, on which an insertion needle is mounted, movably mounted in the guiding housing between a pre-insertion position, at least one insertion position and at least one retracted position, a first return means stressed when the needle housing is in the pre-insertion position and driving the needle housing from the pre-insertion position to the at least one insertion position in released state, a second return means, stressed when the needle housing is in the pre-insertion position and in the at least one insertion position and driving the needle housing from the at least one insertion position to the at least one retracted position in released state.

A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

In some embodiments a system and method are described for safeguarding a hazard. The hazard, for example a needle point, may be moved between a protected retracted position, an active extended position and/or an intermediate position. Optionally in the retracted position, the hazard may be protected inside a housing. Optionally in the extended position, the hazard may be exposed. Optionally, in the intermediate position the hazard may be partially protected and/or concealed, for example by a shield and/or in an indentation. In some embodiments, compromising a shield causes the hazard to be retracted to the retracted position.

A therapeutic agent delivery system (10) includes a housing (16) and a drive wheel (38) rotatably carried by the housing. A plunger rod (50) may be rotatable with the drive wheel relative to the housing from a first rotational configuration to a second rotational configuration. The plunger rod may be translatable relative to the housing from a first translational configuration to a second translational configuration. A plunger restraint (58) may maintain the plunger rod in the first translational configuration when the plunger rod is disposed in the first rotational configuration. The plunger restraint may permit the plunger rod to translate to the second translational configuration when the plunger rod is disposed in the second rotational configuration. A needle may move from a stowed configuration to a deployed configuration by the plunger rod when the plunger rod moves from the first translational configuration to the second translational configuration.

Exemplary embodiments provide wearable automatic injection devices for administering a therapeutic agent to a patient's body at fast, controlled rates, for example, in a single fast bolus. Exemplary embodiments also provide methods for assembling wearable automatic injection devices for administering a therapeutic agent to a patient at fast, controlled rates. Exemplary embodiments also provide methods for using wearable automatic injection devices for administering a therapeutic agent to a patient at fast, controlled rates.

A catheter assembly including a catheter carried by a catheter adapter, a needle having a sharp distal tip and disposed in the catheter such that in a first needle position, the needle extending beyond the catheter, a septum actuator having openings, the septum actuator disposed in the catheter adapter and configured to pierce a septum, and a spring clip disposed in the septum actuator and engaging the openings of the septum actuator in the first needle position.

A syringe assembly (1) having a flexible reservoir (2) containing fluid (3) at a proximal end, which is connected to a needle holding section (5) by a passageway (4) at an exit end of the reservoir. The reservoir has a seal (9) over the exit end to protect the fluid from exposure to air or contamination. The needle-holding section is threadably connected to the passageway so when the needle holding section is rotated inward toward the reservoir an inner portion of the needle (10) can pierce the seal to allow the fluid in the reservoir to pass through the needle into a user’s body when the reservoir is squeezed or depressed. A spring (12) attached to the needle holding section surrounds the length of the needle acts as a cover to help prevent accidental needle pricks.

An injector comprises a medicament container, an injection module and a driving mechanism. The injection module comprises a conversion mechanism and a needle output mechanism connected to each other. The conversion mechanism is assembled and connected to the medicament container. A driving piston set in the conversion mechanism is assembled and connected to the driving mechanism. A needle set in the needle output mechanism is used for piercing a human body. The driving mechanism drives the driving piston set to convey a medicament liquid in the medicament container to the needle set for injection, such that the medicament container and the injection module, which are related to safety and hygiene, are of single use and are disassembled and discarded after being used. The conversion mechanism is externally connected to the driving mechanism, so that the driving mechanism does not contact the injection medicament liquid during injection and can be reused, thereby reducing material waste.