The present disclosure relates to a syringe including a container, for containing a primary fluid, and at least one secondary fluid chamber configured to contain a secondary fluid. The container comprises a proximal end and a distal end and having a distal end opening at the distal end. The syringe further comprises a stopper, movably arranged within the container; and a plunger engageable with the stopper and configured to apply a force to the stopper to move the stopper within the container towards the distal end of the container, to expel primary fluid from the container through the distal end opening. The plunger is further configured to expel secondary fluid from the at least one secondary fluid chamber towards the distal end opening, to expel at least a portion of a residual volume of primary fluid through the distal end opening. A plunger system and assembly for a syringe and methods of expelling fluid from a syringe are also disclosed.

A medicament delivery device comprises a housing and a syringe axially movable in the housing and the syringe having a barrel. The device further comprises a stopper axially movable in the barrel and which separates a first chamber and second chamber from one another. The stopper is axially movable in the barrel in response to a vapour pressure being received in the second chamber. The device also includes a biasing mechanism to axially move the syringe in the housing between a first syringe position and a second syringe position in response to a first reduction in the vapour pressure in the second chamber. In the first syringe position venting of the propellant from the second chamber through a first fluid pathway is permitted to enable the first reduction in the vapour pressure in the second chamber while venting of the propellant from the second chamber through a second fluid pathway is substantially prevented. In the second syringe position venting of the propellant from the second chamber through the second fluid pathway is permitted to enable a second reduction in the vapour pressure in the second chamber.

A therapeutic agent delivery system (10) includes a housing (16) and a drive wheel (38) rotatably carried by the housing. A plunger rod (50) may be rotatable with the drive wheel relative to the housing from a first rotational configuration to a second rotational configuration. The plunger rod may be translatable relative to the housing from a first translational configuration to a second translational configuration. A plunger restraint (58) may maintain the plunger rod in the first translational configuration when the plunger rod is disposed in the first rotational configuration. The plunger restraint may permit the plunger rod to translate to the second translational configuration when the plunger rod is disposed in the second rotational configuration. A needle may move from a stowed configuration to a deployed configuration by the plunger rod when the plunger rod moves from the first translational configuration to the second translational configuration.

A method includes protecting an entire length of a needle of a needle-based device in a first state of disuse thereof with a needle cap, encompassing, by a needle shield, the entire length of the needle and at least a partial length of the needle cap in the first state of disuse, and encompassing an entire protruding length of the needle cap outside the needle shield within a safety cap and securing the safety cap onto an outer surface of the needle shield such that the needle and the needle cap are completely protected and covered during the first state of disuse. Following removing the safety cap along with the needle cap from the needle shield, the method also includes retracting the needle shield to cause the needle to emerge out of the needle shield to prepare the needle-based device for a second state of use thereof.

This invention is a syringe having a tubular sleeve protector. The syringe has a barrel with an injection needle and a guide pin on an exterior surface of the barrel. The barrel and the injection needle are in an interior of a tubular sleeve has a spiral guide track on an interior wall. The guide pin fits in the spiral guide track and moves the barrel towards a bottom end of the tubular sleeve as the barrel is rotated, thereby extending the injection needle out of the tubular sleeve. A lateral guide track connects the spiral guide track to a vertical guide track. The guide pin moves from the bottom of the spiral guide track through the lateral guide track to the vertical guide track when the syringe barrel is further rotated. The injection needle is retracted into the interior of the tubular sleeve when the guide pin is moved into the vertical guide track and moved upwards in the vertical guide track towards a top end of the tubular sleeve.

Single and dual packaging for fill needles and safety needles are described herein. Such packaging can include hard packaging or blister packs. Such packaging can include a premature activation prevention element disposed on an inner sidewall of a compartment of the packaging to nest within a recess of a tether of a safety needle device to prevent accidental activation of the safety needle device prior to use by the user.

A method includes protecting an entire length of a needle of a needle-based device protruding from a needle mount coupled to a body thereof based on providing a needle shield configured to completely encompass the entire protruding length of the needle in a first state of disuse of the needle-based device, and retracting the needle shield in a first direction toward the body to cause the needle to emerge out of the needle shield to prepare the needle-based device for a second state of use. The method also includes transitioning the needle-based device back to the first state of disuse in accordance with a force applied in a second direction, securedly maintaining the needle shield in the first state of disuse, and locking the needle shield with a lock button formed on the needle shield or external thereto in the first state of disuse of the needle-based device.

Exemplary embodiments provide wearable automatic injection devices for administering a therapeutic agent to a patient's body at fast, controlled rates, for example, in a single fast bolus. Exemplary embodiments also provide methods for assembling wearable automatic injection devices for administering a therapeutic agent to a patient at fast, controlled rates. Exemplary embodiments also provide methods for using wearable automatic injection devices for administering a therapeutic agent to a patient at fast, controlled rates.

A syringe with passive needle protection for administering a medicament dose to a patient, comprising a hollow body forming the syringe housing and containing the medicament active substance, at the distal end of which a hollow needle provided for injection of the active substance is mounted in a bearing sleeve, and in which a displaceable plunger provided at the end with a receiving hole for the hollow needle is arranged, for the most complete possible delivery of medicament while avoiding undelivered medicament residues. For this purpose, the piston is designed in several parts; in addition to a needle holder having a retaining clip for the hollow needle, it comprises a piston jacket which is shaped such that, when the needle holder is inserted, it leaves free inflow channels into the enclosed end of the hollow needle for the active substance on both sides of the retaining clip.

A method includes protecting an entire length of a needle of a needle-based device protruding from a needle mount coupled to a body thereof based on providing a needle shield completely encompassing the entire protruding length of the needle in a first state of disuse, and retracting the needle shield in a first direction toward the body of the needle-based device to apply a first force in the first direction to cause the needle to emerge out of the needle shield to prepare the needle-based device for a second state of use. The method also includes transitioning the needle-based device back to the first state of disuse following the second state of use in accordance with applying a second force in a second direction diametrically opposite to the first direction, and providing a lock button to lock the needle shield in the first state of disuse.