The disclosed compositions, methods, and devices are useful in freezing, storing, and administering therapeutic eukaryotic cells to a patient in need thereof. In many embodiments, the disclosed therapeutic cells are mammalian cells derived from human intervertebral disc tissue. The disclosed compositions, methods, and devices are able to maintain high viability and sterility of the therapeutic cells, and allow the cells to be administered to a patient directly from the freezing container without manipulation of the cells or transferring to a second container.

The disclosure pertains to a safety syringe having a retractable needle shield which is capable of being retracted to expose the needle for use; being advanced to a needle shielding position; and, if desired, of being removed from the syringe with the shielded needle safely contained within the retractable needle shield via a frangible segment between the syringe barrel and the needle/needle shield components. The disclosure further pertains to a method of using the safety syringe having a retractable needle shield.

An insertion assembly and method of manufacturing an insertion assembly. The method includes forming a catheter assembly including a catheter hub and a catheter, inserting a needle into the catheter assembly such that a distal tip of the needle extends distal of a distal end of the catheter, and permanently adhering an interface pad to the catheter hub. The interface pad can include a foam material including a haemostatic agent. The haemostatic agent can include microdispersed oxidized cellulose. The foam material can further include an antimicrobial agent such as chlorhexidine gluconate.

Needle shielding systems are disclosed. The needle shielding system comprises a needle, a cover sleeve, and a needle shield. The needle has a needle tip and a needle bulge spaced apart from the needle tip. The cover sleeve is slidably mounted over the needle and comprises an end portion having an internal diameter smaller than the width of the needle bulge, and a cover sleeve shaft extending from the end portion towards the needle tip and having an internal diameter larger than the width of the needle bulge. The needle shield comprises a base plate slidably mounted over the needle adjacent to the end portion, and at least one resilient arm extending from the base plate towards the needle tip. In use the needle shield and cover sleeve move along the needle until the end portion contacts the needle bulge and the cover sleeve shaft and the arm cover the needle tip.

A medical delivery device is provided for delivering a medicinal substance into a user's body. A foldable hub has a left wing and a right wing, where the hub is attached at one end to a tube, and at an opposite end to a needle. At least one first rib is disposed on the left wing and at least one second rib is disposed on the right wing. When the wings are folded back away from the needle and pinched together, the first and second ribs prevent twisting and/or sliding of the wings relative to each other during an insertion of the needle into a user's skin, thereby preventing a breakage of the needle due to undesirable movement of the wings.

In a syringe that allows an administration operation while a coil spring is held by a spring holder in a compressed state and a further thrust operation of the syringe barrel after completion of administration releases the coil spring from the hold of the spring holder, the coil spring is prevented from being released from the hold of by the spring holder inadvertently during administration. When, upon completion of administration of the liquid drug, the syringe barrel 2 is thrust toward the distal end relative to the cover 6, the spring holder 17 is configured to be movable from a hooked position toward the distal end relative to the cover 6, where the hook members 17b are hooked on the cover 6 when in the hooked position, and a guide surface S is provided on the inner periphery of the cover 6 adapted, when the spring holder 17 has moved from the hooked position toward the distal end, to cause the hook members 17b to radially deform such that the hook members cease to be hooked on the cover 6.

A medical safety needle is comprised of a needle body having a needlepoint, a covering body having a detent portion slidable on the needle body to catch the needlepoint so as to cover the needlepoint, and a resilient cantilever supporting the detent portion, a sleeve following the covering body to cover a side face of the needle body, a collar portion slidably fitting on the covering body, which is configured to get in contact with the cantilever to press the cantilever radially inwardly, and a housing being formed in a unitary body with the collar portion or having an end face on which the collar portion is capable of being seated, the housing being configured to carry the covering body from a first position to have the needlepoint exposed to a second position to have the needlepoint covered by the covering body.

In a safety apparatus for medical needles, when leg portions are extended from a first folded position to a second extended position, a distal end of a needle is introduced into a space of a shield member connection hub, and a first blocking wall and a second blocking wall overlap so as to block the cross section of the space to form a double blocking wall and blocks the cross section of the space. The double blocking wall is capable of preventing the distal end of the needle from moving downward from the double blocking wall and preventing the distal end of the needle from being exposed to the outside of the apparatus.

An extravascular system is provided which includes a catheter adapter having a blood control septum configured to control flow of a fluid through the catheter adapter, the catheter adapter further having a catheter configured for intravenous insertion. The extravascular system further includes a septum activator slidably inserted within the catheter adapter and configured for advancement through the blood control septum to provide a fluid pathway through the blood control septum. Further still, the extravascular system includes an external safety mechanism comprising a needle hub and a needle shield interconnected via a tether, wherein the needle shield includes a safety clip that is configured to retain a sharpened end of the introducer needle within the needle shield. Some implementations further comprise an access port forming a portion of the catheter adapter and providing selective access to the lumen of the catheter adapter.

Devices for protecting a user from a sharp tip of a medical needle includes a central body portion, a medical needle having a sharp tip, a pair of wings in attachment to the central body portion. The medical needle includes a longitudinal axis that is substantially perpendicular to at least one of a long axis of the central body portion and the delivery tube. The pair of wings are selectively positionable in a first position in which the pair of wings are spaced apart from the medical needle and a second position in which the pair of wings are proximate the medical needle. A mechanical fastener is disposed on at least one of the pair of wings, the mechanical fastener configured to selectively attach the pair of wings together in the second position with the medical needle positioned therebetween. Methods of using the device including administering medicinal fluids.