Disclosed in the present specification is a method capable of preparing N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide (INT028-2) with high optical purity, through the selection of Ellman-chiral auxiliaries and the re-crystallization and separation of optical isomers. According to the above method, high-purity N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide with excellent quality can be produced at room temperature by improving cryogenic process conditions necessary for realizing high optical purity, and thus the trimming due to the process failure rate can be remarkably reduced.

A target bipyridine compound is synthesized with high purity and a high yield in a simple and safe manner in a short period of time. A method for synthesizing a di-tert-butyl-2,2-bipyridine compound is provided, and the method includes a step of reacting, in a reaction solvent, a tert-butylpyridine compound with a dispersion product obtained by dispersing an alkali metal in a dispersion solvent. A method for synthesizing a bipyridine compound having no substituents is also provided, and the method includes a step of reacting, in a reaction solvent, pyridine with a dispersion product obtained by dispersing an alkali metal in a dispersion solvent.

Provided is a purifying method for dabigatran etexilate free base, comprising subjecting a dabigatran etexilate free base crude product to water slurrying to obtain a crude product B; then conducting recrystallization on the crude product B with acetone and water to obtain a crude product C; and subsequently, purifying the crude product C with a mixed solvent of tetrahydrofuran and ethyl acetate, filtering and drying to obtain a dabigatran etexilate free base finished product. The purifying method of the present invention can effectively remove various impurities and is suitable for workshop production. Salts and water-soluble organic impurities are removed by purified water slurrying, impurities with a high polarity are removed by purifying with an acetone-water solution, and impurities with a low polarity are removed by purifying with a mixed solvent of tetrahydrofuran and ethyl acetate.

A process for treating wastewater or waste brines that include sodium and chloride ions. The waste brine is concentrated and thereafter directed to a Mirabilite crystallizer that produces hydrated sulfate salt crystals and a first solution. The hydrated crystals are melted to form an aqueous sulfate solution that is directed to a sodium sulfate crystallizer which produces sodium sulfate salt crystals. The first solution produced by the Mirabilite crystallizer is directed to a nanofiltration device which produces a permeate stream and a reject stream containing sulfate removed by the nanofiltration device. The permeate stream is directed to a sodium chloride crystallizer that produces sodium chloride salt crystals. The reject stream is recycled to the Mirabilite crystallizer.

A vertically-integrated cannabis-related product production method is described, the method comprises, producing a distilled cannabinoid and/or a crystallized cannabinoid from cannabis plants, comprising: in a farming system, growing the cannabis plants, the cannabis plants comprise a cannabinoid; in an extraction system, extracting the cannabinoid from the cannabis plants; in a purification system, purifying the cannabinoid to produce a purified cannabinoid; and in a distillation and/or a crystallization system, distilling and/or crystallizing the purified cannabinoid to produce the distilled cannabinoid and/or the crystallized cannabinoid. Various ways to purify, distill, and process the cannabinoids are described. An insect pest management system may be integrated with the farming system to grow the cannabis plants in the presence of predatory mites which feed on insects and/or spider mites.

The invention discloses a method and crystallization device for preparing electronic-grade nickel sulfate from nickel powder, and a control method of the crystallization device, and relates to the technical field of non-ferrous metal hydrometallurgy. The method comprises: oxidation, cooling, acid leaching, copper removal, acid adjustment, concentration, cooling crystallization, drying and screening, and secondary leaching: the oxidation comprises: controlling a temperature of nickel powder in a calcining furnace to be 400 C. to 700 C., allowing a use amount of compressed air for each kilogram of nickel powder to be 1 m.sup.3 to 5 m.sup.3, and making the reaction last for 1.0 hour to 2.5 hours; and the acid leaching comprises: placing cooled nickel oxide in a reactor, controlling a temperature to be 45 C. to 70 C., adding dilute sulfuric acid to control a pH value to be 0.5 to 1.5, and making the reaction last for 1 hour to 3 hours.

The present invention relates to a method for extracting, separating and purifying compounds of interest obtained from essential oils and plant extracts which is continuously held.

A method of separating material, such as foam, sludge, oil or grease, at a fluid's surface, by applying acoustic pressure shock waves to the material and the fluid's surface such that acoustic pressure shock waves are propagated in liquid medium of the fluid and in gas medium above the fluid surface.

A method of activating and dewatering sludge through application of acoustic pressure shock waves to wastewater.

Acoustic pressure shock waves are applied to a membrane in a fluid to prevent attachment of or dislodge biological or solid matter for membrane cleaning or desalination with a membrane.